A5101415113- Metallurgy and Material Forming
- Cardiovascular Health and Disease Prevention
- Metal Forming Simulation Techniques
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Bioactive Compounds and Antitumor Agents
- Manufacturing Process and Optimization
- Hormonal and reproductive studies
- Fault Detection and Control Systems
- Phytoestrogen effects and research
- Blood Pressure and Hypertension Studies
- Diabetes Management and Research
- Cardiovascular Function and Risk Factors
- Synthesis of Indole Derivatives
- Chronic Kidney Disease and Diabetes
- Chronic Disease Management Strategies
- Diabetes Management and Education
- Synthesis of Organic Compounds
- Birth, Development, and Health
- Reliability and Maintenance Optimization
- Organic Chemistry Cycloaddition Reactions
- Retinal Diseases and Treatments
- Machine Fault Diagnosis Techniques
- Biochemical Analysis and Sensing Techniques
- Plant Toxicity and Pharmacological Properties
- Traditional Chinese Medicine Analysis
Shanghai Jiao Tong University
2015-2024
Ruijin Hospital
2012-2024
Zunyi Medical University
2023
Shandong First Medical University
2023
Bridge University
2021
Southwest Hospital
2020
Creative Commons
2020
Army Medical University
2020
Shanghai Clinical Research Center
2014-2016
Shanghai Institutes for Biological Sciences
2016
Abstract Background The triglyceride-glucose index (TyG index) has been proposed as a simple and reliable alternative insulin resistance (IR) marker, while the homeostasis model assessment for IR (HOMA-IR) is most frequently used index. Few studies have evaluated role of assessed by TyG HOMA-IR on arterial stiffness in type 2 diabetes (T2D) population with high risk increased stiffness. We aimed to investigate association patients T2D. Methods recruited 3185 T2D, who underwent brachial-ankle...
To explore the mechanisms underlying azole resistance in clinical isolates of Candida tropicalis collected China by focusing on their efflux pumps, respiratory status and antifungal target enzyme. Fifty-two C. were from five hospitals four provinces susceptibility tests performed. Rhodamine 6G rhodamine 123 used to investigate pumps status, respectively. Transporter-related genes CDR1 MDR1, mitochondrial gene CYTb, as well ERG11, quantified real-time RT–PCR. Meanwhile, ergosterol content was...
Introduction Early screening for diabetic retinopathy (DR) with an efficient and scalable method is highly needed to reduce blindness, due the growing epidemic of diabetes. The aim study was validate artificial intelligence-enabled DR investigate prevalence in adult patients diabetes China. Research design methods prospectively conducted at 155 centers A non-mydriatic, macula-centered fundus photograph per eye collected graded through a deep learning (DL)-based, five-stage classification....
Abstract Inactivating MEN1 mutations are the most common genetic defects present in sporadic and inherited pancreatic neuroendocrine tumours (PNETs). The lack of interventional therapies prompts us to explore therapeutic approach targeting β-catenin signalling -mutant PNETs. Here we show MEN1- encoded scaffold protein menin regulates phosphorylation β-catenin. is activated human mouse Conditional knockout suppresses tumorigenesis growth Men1 -deficient PNETs, significantly prolongs survival...
Some studies have assessed the predictive role of atherogenic index plasma (AIP) for macrovascular diseases. This prospective investigation aimed to elucidate whether AIP is associated with diabetic kidney disease (DKD) and retinopathy (DR) incidence.
The mechanism underlying the increased susceptibility of type 2 diabetes in offspring maternal malnutrition is poorly determined. Here we tested hypothesis that functional microRNAs (miRNAs) mediated low-protein (LP) isocaloric diet induced pancreatic β-cell impairment. We performed miRNA profiling islets from LP and control mothers to explore potential miRNAs responsible for dysfunction. found exhibited impaired glucose tolerance due decreased mass insulin secretion. Reduction proliferation...
To determine whether the follow-up frequency for type 2 diabetes mellitus (T2DM) patients in National Metabolic Management Centers (MMCs) leads to different clinical outcomes.
A novel adhering polyurethane (PU), based on hydrolysable tannins that contain a number of active sites, was successfully synthesized and characterized. The sites were catechol groups in the tannins, which used as substitute for dopamine. This efficient, universal, low cost coating cured by adding FeCl3, evaluated nuclear magnetic resonance (1H-NMR), Fourier transform infrared (FTIR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) UV-Visible spectrophotometry...
Abstract Background Atherosclerosis is a common complication in patients with type 2 diabetes (T2DM). Multiple factors are involved the development and progress of atherosclerosis. We evaluated association weekly sedentary time (WST) carotid plaque formation. Methods After data cleaning, total 26 664 participants T2DM from 10 National Metabolic Management Centers (MMCs) June 2017 to April 2021 were enrolled. Self‐reported lifestyle including WST, sleeping time, smoking drinking information,...
Siraitia fructus, known as Luo-Han-Guo (LHG) in Chinese, shows good antidiabetic activity. Gut microbiota have emerged parameter of the pathophysiology type 2 diabetes (t2D) mellitus. In this study, vitro biotransformation LHG extract by t2D and normal human intestinal was analyzed using ultraperformance liquid chromatography with time-of-flight mass spectrometry. A total 19 12 metabolites were characterized microbiota, respectively. These formed a series metabolic reactions including...
It is common practice for Singapore wastewater treatment plant (WWTP) to treat primary sludge and secondary active by anaerobic digestion (AD) recover energy through biogas. However, sewage (SS) low in biodegradable organic matter biomethane potential, which result AD efficiency both from a processing an economic standpoint. Co-digestion of SS together with food waste (FW) not only provides practical alternative FW management, but also improves the performance often under-performed digester...
Abstract Purpose Preterm children with cerebral palsy (CP) often have varying hand dysfunction, while the specific brain injury periventricular leukomalacia (PVL) cannot quite explain its mechanism. We aimed to investigate glymphatic activity using diffusion tensor image analysis along perivascular space (DTI-ALPS) method and evaluate association lesion burden dysfunction in CP secondary PVL. Methods retrospectively enrolled 18 bilateral spastic due PVL 29 age- sex-matched typically...
The present study aimed to explore the influence of sirtuin 1 (SIRT1) polymorphisms (rs12778366 and rs3758391) on diabetic foot (DF) susceptibility severity in patients with type 2 diabetes mellitus (T2DM). This case–control recruited 142 DF, 148 T2DM, healthy controls. SIRT1 gene were sequenced by polymerase chain reaction (PCR) direct sequencing method. relative expression mRNA was estimated using quantitative real-time PCR (qRT-PCR) assay. Odds ratio (OR) 95% confidence interval (95% CI)...
To investigate the different efficacies of glycemic control between basal and premixed insulin in participants with type 2 diabetes (T2DM) when non-insulin medications fail to reach treatment targets.This was a prospective, large-scale, real-world study at 10 centers China. Between June 2017 2021, we enrolled 1104 T2DM initiated either once-daily or twice-daily glycosylated hemoglobin (HbA1c) target not met after least two agents were administered. A Cox proportional hazards regression model...
Glycemic variability plays an important role in the development of cardiovascular disease (CVD). This study aims to determine whether long-term visit-to-visit glycemic is associated with aortic stiffness progression participants type 2 diabetes (T2D).Prospective data were obtained from 2115 T2D National Metabolic Management Center (MMC) June 2017 December 2022. Two brachial-ankle pulse wave velocity (ba-PWV) measurements performed assess over a mean follow-up period 2.6 years. A multivariate...
This article presents a tolerance modelling and robust design approach to support concurrent engineering. method allows the designer synthetically specify dimensional geometric tolerance, considering assembly functional requirements (AFRs) manufacturing costs. First, features of ISO/TC 213 are used as basis for construction network model assembly. Second, cost-tolerance cylindrical planar is established. addresses not only tolerances but also nominal parameters. Finally, optimization...
An improved synthetic method of 2-formyl-1,4,5,8-tetramethoxynaphthalene in 73% overall yield is described. This has several advantages compared with the reported synthesis: first, reactant cheaper and higher; second, reaction condition milder reagent used more friendly to environment; third, workup each step simpler; fourth, protocol suitable for large-scale preparation.
SIRT1, a class III histone/protein deacetylase (HDAC), has been associated with autoimmune diseases. There is paucity of data about the role SIRT1 in Graves' disease. The aim this study was to investigate pathogenesis GD. Here, we showed that expression and activity were significantly decreased GD patients compared healthy controls. NF-κB pathway activated peripheral blood patients. reduced levels correlated strongly clinical parameters. In euthyroid patients, markedly upregulated downstream...
// Ying Peng 1, * , Yicheng Qi Fengjiao Huang 1 Xinxin Chen Yulin Zhou Lei Ye Weiqing Wang Guang Ning 2 Shu Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrinology Metabolism, Ruijin Hospital, Affiliated to Jiao-Tong University School Medicine, 200025, China Laboratory Institute Health Sciences, Institutes Biological Sciences (SIBS), Chinese Academy (CAS) & Jiao Tong Medicine (SJTUSM), These authors have contributed equally this work Correspondence to:...