A5026085729- Thyroid Cancer Diagnosis and Treatment
- Thyroid Disorders and Treatments
- RNA Research and Splicing
- Neuroendocrine Tumor Research Advances
- Pituitary Gland Disorders and Treatments
- Ophthalmology and Eye Disorders
- RNA modifications and cancer
- Metabolism, Diabetes, and Cancer
- Cancer-related molecular mechanisms research
- Pharmacological Effects of Natural Compounds
- Blood groups and transfusion
- Ginseng Biological Effects and Applications
- Genetic factors in colorectal cancer
- Neuroblastoma Research and Treatments
- Cancer, Lipids, and Metabolism
- Bone and Dental Protein Studies
- Cancer, Hypoxia, and Metabolism
- RNA and protein synthesis mechanisms
- RNA regulation and disease
- Ubiquitin and proteasome pathways
- Hormonal Regulation and Hypertension
- Growth Hormone and Insulin-like Growth Factors
- Medicinal Plants and Bioactive Compounds
- Thermography and Photoacoustic Techniques
- Hormonal and reproductive studies
Ruijin Hospital
2007-2024
Shanghai Jiao Tong University
2015-2024
Zhejiang Normal University
2021-2024
Fudan University Shanghai Cancer Center
2023
Shanghai Ninth People's Hospital
2021
Kunming Medical University
2019
Jilin University
2015
Tsinghua University
2013-2014
Sichuan University
2010
West China Hospital of Sichuan University
2010
Abstract Context Supplemental methotrexate (MTX) may affect the clinical course of Graves’ disease (GD). Objective To evaluate efficacy add-on MTX on medical treatment in GD. Design Prospective, open-label, randomized supplementation controlled trial. Setting Academic endocrine outpatient clinic. Patients One hundred fifty-three untreated hyperthyroid patients with Intervention received 10 mg/w methimazole (MMI) or MMI only. and were discontinued at months 12 to 18 euthyroid patients. Main...
Viruses deploy multiple strategies to suppress the host innate immune response facilitate viral replication and pathogenesis. Typical G3BP1+ stress granules (SGs) are usually formed in cells after virus infection restrain translation stimulate immunity. Thus, viruses have evolved various mechanisms inhibit SGs or repurpose SG components such as G3BP1. Previous studies showed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inhibited immunity during early stage of COVID-19....
Summary Objective Multiple endocrine neoplasia type 2 is caused by autosomal dominant gain‐of‐function mutations in the RET proto‐oncogene, which includes multiple 2A (MEN2A), 2B (MEN 2B), and familial medullary thyroid carcinoma (FMTC). In this paper we present phenotype–genotype correlation of 20 unrelated Chinese families with 15 cases MEN2A five MEN2B. Design Cross‐sectional study. Patients A total 147 members from were included. Among them, 119 family pedigrees (including probands) 28...
Cordycepin possesses anti-inflammatory, anti-metastatic and anti-tumor properties.The present study investigates the anti-hepatocellular carcinoma activities of cordycepin in vitro vivo models.Cell viability, apoptosis rate, intracellular reactive oxygen species (ROS) level mitochondrial membrane potential (MMP) were determined by 3-(4,5)-dimethylthiahiazo(-z-y1)-3,5-di-phenytetrazoliumromide bromide assay, annexin V/propidium iodide double staining, 2',7'-dichlorfluorescein-diacetate...
Background: Diagnosis of thyrotropin (TSH)-secreting pituitary adenomas (TSHoma) before surgery remains a challenge, especially for microadenomas. We aimed to establish short-term somatostatin analogue (SSA) test differentiate TSHomas from other causes syndromes inappropriate secretion TSH (IST), mainly resistance thyroid hormone β (RTHβ). Materials and Methods: first evaluated the sensitivity specificity SSA in training cohort (TSHoma, n = 32; RTHβ, 20). The was then validated an...
Abstract Context Fusion oncogenes, especially those involving RET or NTRK, are known drivers of papillary thyroid cancer (PTC). They prevalent in pediatric patients and correlate with aggressive tumor behavior. Objective We explored the age dependence fusion oncogenes behavior young adult PTC patients. Experimental Design examined 150 tumors from 142 aged between 17∼35 years old established tumor-node-metastasis stages. Oncogenic differentiation score (TDS) were determined by DNA RNA...
Abstract Aim To determine the association of presence diabetes and, among persons with diabetes, age at type 2 mellitus (T2DM) onset, BMI and interactive effect subsequent thyroid cancer risk. Materials Methods We conducted a population register‐based longitudinal cohort study in Shanghai, including 428 568 new‐onset T2DM matched general population. The risk subgroups was calculated based on standardized incidence ratio (SIR), hazard (HR) Cox proportional hazards models. Results In total,...
Abstract Context Thyroid stimulating immunoglobulin (TSI) and thyrotropin receptor antibody (TRAb) are specific biomarkers for Graves’ disease (GD), but their clinical characteristics not fully understood. Objectives To clarify the features prognostic significance of TSI TRAb in patients with GD. Design A retrospective data analysis a follow-up study. Methods Medical records newly diagnosed GD were examined. correlations assessed using Passing–Bablok regression Bland-Altman plot. Patients...
// Ying Peng 1, * , Yicheng Qi Fengjiao Huang 1 Xinxin Chen Yulin Zhou Lei Ye Weiqing Wang Guang Ning 2 Shu Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrinology Metabolism, Ruijin Hospital, Affiliated to Jiao-Tong University School Medicine, 200025, China Laboratory Institute Health Sciences, Institutes Biological Sciences (SIBS), Chinese Academy (CAS) & Jiao Tong Medicine (SJTUSM), These authors have contributed equally this work Correspondence to:...
A combination of glucocorticoids with mycophenolate is recommended by current guidelines to boost response Graves' orbitopathy (GO) therapy. This study was designed evaluate the therapeutic effects and safety methotrexate (MTX) plus reduced (3.0 g) or full-dose (4.5 i.v. methylprednisolone (MP) vs MP alone.This a prospective, randomized, observer-masked, single-center clinical trial conducted in tertiary center. Ninety-seven patients active moderate-to-severe GO were screened 90 underwent...
Background: Ameloblastoma is the most frequent odontogenic tumor.Various evidence has highlighted role of somatic mutations, including recurrent mutation BRAF V600E, in tumorigenesis Ameloblastoma, but intact genetic pathology remains unknown.Material and Methods: We sequenced whole exome both tumor tissue healthy bone from four mandibular ameloblastoma patients.The identified mutations were integrated into Weighted Gene Co-expression Network Analysis on publicly available expression data...
Abstract Monocytes are important mediators of immune system and reported to be altered in autoimmune disorders. Little is known about the pathological role monocytes Graves’ disease (GD). Thus, we investigated periphery thyroid tissue GD. Untreated GD patients were enrolled followed up until remission. significantly increased positively correlated with anti-thyrotropin receptor antibody (TRAb) untreated ( r counts = 0.269, P < 0.001; percentage 0.338, 0.001). Flow cytometry showed CD14++...
The bioassay of thyroid-stimulating immunoglobulin was reported to have a similar performance the commonly used hormone binding inhibition assay, also known as thyroid receptor antibody assay. normal reference range levels indicates withdrawal anti-thyroid drugs in recent clinical guidelines.A prospective, longitudinal observational study conducted evaluate prognostic value patients with Graves' disease.A total 77 disease treated were continuous follow-up until 1 year after discontinuation....
Graves’ disease (GD) is a common autoimmune that affects the thyroid gland. As new class of modulators gene expression, long noncoding RNAs (lncRNAs) have been reported to play vital role in immune functions and development autoimmunity disease. The aim this study identify lncRNAs CD4+ T cells as potential biomarkers GD. lncRNA mRNA microarrays were performed differentially expressed mRNAs GD compared with healthy control cells. Quantitative PCR (qPCR) was used validate results, correlation...