A5103050184- Genomics and Phylogenetic Studies
- Thyroid Cancer Diagnosis and Treatment
- Genetic diversity and population structure
- Aquaculture disease management and microbiota
- Invertebrate Immune Response Mechanisms
- Chromosomal and Genetic Variations
- Ichthyology and Marine Biology
- Crustacean biology and ecology
- Fish biology, ecology, and behavior
- Thyroid and Parathyroid Surgery
- Marine Invertebrate Physiology and Ecology
- Sexual Differentiation and Disorders
- Electromagnetic wave absorption materials
- Silk-based biomaterials and applications
- Hormonal and reproductive studies
- Head and Neck Anomalies
- Thyroid Disorders and Treatments
- Skin Protection and Aging
- Turtle Biology and Conservation
- Venomous Animal Envenomation and Studies
- Nanofabrication and Lithography Techniques
- Smart Materials for Construction
- Subterranean biodiversity and taxonomy
- Machine Learning in Bioinformatics
- Fuel Cells and Related Materials
Northwestern Polytechnical University
2020-2025
Ruijin Hospital
2020-2024
Shanghai Jiao Tong University
2020-2024
Henan University of Science and Technology
2024
South China University of Technology
2017-2024
Taipei City Government
2023
Huazhong University of Science and Technology
2018
Technical Institute of Physics and Chemistry
2018
Chinese Academy of Sciences
2014-2018
Xinjiang Technical Institute of Physics & Chemistry
2014
Chlorogenic acid (CGA), the ester formed between caffeic and l-quinic acid, is a widespread phenolic compound. It part of human diet, found in foods such as coffee, apples, pears, etc. CGA also was widely used cosmetics, but effects on melanogenesis are unknown. In this study, we analyzed cell proliferation, melanin content tyrosinase B16 murine melanoma cells. Additionally, enzymatic reactions cells lytic solution were detected by UV spectrophotometry. Results showed at 30 60 μM...
Abstract Background The swimming crab, Portunus trituberculatus, is an important commercial species in China and widely distributed the coastal waters of Asia-Pacific countries. Despite increasing interest crab research, a high-quality chromosome-level genome still lacking. Findings Here, we assembled first reference P. trituberculatus by combining short reads, Nanopore long Hi-C data. assembly size was 1.00 Gb with contig N50 length 4.12 Mb. In addition, BUSCO assessment indicated that...
Abstract The evolutionary and genetic origins of the specialized body plan flatfish are largely unclear. We analyzed genomes 11 species representing 9 14 Pleuronectiforme families conclude that Pleuronectoidei Psettodoidei do not form a monophyletic group, suggesting independent from different percoid ancestors. Genomic transcriptomic data indicate genes related to WNT retinoic acid pathways, hampered musculature reduced lipids might have functioned in evolution Pleuronectoidei. Evolution...
As an important freshwater aquaculture species in China, the Chinese mitten crab (Eriocheir japonica sinensis) has high economic and nutritional value. However, limited genomic information is currently available for studying its basic development genetic diversity. Here, we performed whole-genome sequencing on Oxford Nanopore Technologies Limited's platform using promethION. The assembled size of E. j.sinensis genome was approximately 1.27 Gb, which close to estimated (1.19 Gb). Furthermore,...
<title>Abstract</title> Crabs encompass the infra-orders Brachyura and Anomura, collectively constitute clade Meiura within order Decapoda. Despite their considerable diversity, genomic resources for crabs remain scarce, hindering our understanding of phylogeny genetic mechanisms underlying such unique traits as carcinization. To address these questions, here we sequenced genomes 10 crab species covering all currently controversial taxonomies at section level. Our whole-genome phylogenetic...
Abstract Background Electric eels evolved remarkable electric organs that enable them to instantaneously discharge hundreds of volts for predation, defense, and communication. However, the absence a high-quality reference genome has extremely constrained studies in various aspects. Results Using high-depth, multiplatform sequencing data, we successfully assembled first telomere-to-telomere Electrophorus electricus, which size 833.43 Mb comprises 26 chromosomes. Multiple evaluations,...
Abstract The reissner lamprey Lethenteron reissneri , belonging to the class Cyclostomata, serves as a bridge between invertebrates and jawed vertebrates, is considered sister group of vertebrates. However, despite this evolutionary significance, genetic mechanisms underlying adaptive evolution lineage remain unclear. Here, we assembled 1.06 Gb chromosome‐level draft genome L. with 72 chromosomes (ranging in length from 4.5 Mb 25.9 Mb) scaffold N50 13.23 Mb. Genome quality comparisons...
Gobiocypris rarus is sensitive to environmental pollution, especially heavy metal and grass carp reovirus (GCRV). Hence, it has potential utility as a biological monitor. Genetic deciphering of its unique immune system will advance our understanding adaptive strategies, which provide cues for better application. A de novo genome rare minnow was obtained, sex determination mechanism ZZ/ZW. We identified several specific mutation genes lost minnow, these might be related the sensitivity...
Abstract Background The black widow spider has both extraordinarily neurotoxic venom and three-dimensional cobwebs composed of diverse types silk. However, a high-quality reference genome for the was still unavailable, which hindered deep understanding application valuable biomass. Findings We assembled Latrodectus elegans genome, including size 1.57 Gb with contig N50 4.34 Mb scaffold 114.31 Mb. Hi-C scaffolding assigned 98.08% to 14 pseudo-chromosomes, BUSCO, completeness analysis revealed...
Abstract Horseshoe crabs including Tachypleus tridentatus are a group of marine arthropods and living fossil species which have existed on the earth for ~500 million years. However, genetic mechanisms underlying their unique adaptive ability still unclear. Here, we assembled first chromosome‐level T. genome, proved that this genome is high quality with contig N50 1.69 Mb. By comparison other arthropods, some gene families experienced significant expansion, related to several signaling...
Abstract The blue king crab, Paralithodes platypus , which belongs to the family Lithodidae, is a commercially and ecologically important species. However, high‐quality reference genome for crab has not yet been reported. Here, we assembled first chromosome‐level genome, contains 104 chromosomes an N50 length of 51.15 Mb. Furthermore, determined that large size can be attributed insertion long interspersed nuclear elements tandem repeats. Genome assembly assessment showed 96.54% transcripts...
The ladybird beetle Henosepilachna vigintioctomaculata is an economically significant oligophagous pest that induces damage to many Solanaceae crops. An increasing number of studies have examined the population and phenotype diversity beetles. However, few comparative genome analyses species been conducted. Here, we obtained a high-quality chromosome-level assembly H. using various sequencing technologies, was ~581.63 Mb, with 11 chromosomes successfully assembled. phylogenetic analysis...
Nanocellulose fiber materials were considered promising biomaterials due to their excellent biodegradability, biocompatibility, high hydrophilicity, and cost-effectiveness. However, low proton conductivity significantly limited application as exchange membranes. The methods previously reported increase often introduced non-biodegradable groups compounds, which resulted in the loss of basic advantages this natural polymer terms biodegradability. In work, a green sustainable strategy was...
Abstract Context Fusion oncogenes, especially those involving RET or NTRK, are known drivers of papillary thyroid cancer (PTC). They prevalent in pediatric patients and correlate with aggressive tumor behavior. Objective We explored the age dependence fusion oncogenes behavior young adult PTC patients. Experimental Design examined 150 tumors from 142 aged between 17∼35 years old established tumor-node-metastasis stages. Oncogenic differentiation score (TDS) were determined by DNA RNA...
Green electromagnetic interference (EMI) shielding materials not only require high effectiveness (SE) and low reflection but also need to be recyclable after damage; however, it is challenging strike a balance in practice. Here, polyacrylamide (PAM) composite composed of numerous chemically cross-linked PAM@carbon nanotube (cPAM@CNT) core–shell particles featuring rich wrinkled microstructures was prepared using an adsorption–drying–shrinking strategy. The enable the incident waves (EMWs)...
Jellyfish, such as Chrysaora quinquecirrha, hold an important evolutionary position and have great ecological value. However, limited genomic resources are currently available for studying their basic genetic development processes. Here, we de novo assembled the first high-quality reference genome of C. successfully annotated 21,606 protein-coding genes. Codon usage analysis identified frequent use low-GC-content codons during gene translation. Analysis relative evolution rate indicated that...
Abstract Context Measurement of plasma steroids is necessary for diagnosis congenital adrenal hyperplasia (CAH). We sought to establish an efficient strategy detection and subtyping CAH with a machine-learning algorithm. Methods Clinical phenotype genetic testing were used provide subtype. profiled 13 major steroid hormones by liquid chromatography-tandem mass spectrometry. A multiclassifier system was established distinguish 11β-hydroxylase deficiency (11βOHD), 17α-hydroxylase/17,20-lyase...
East Asians are more susceptible to early-onset diabetes than Europeans and exhibit reduced insulin secretion at earlier stages. PAX4 plays a critical role in the development of β-cells. The dysfunction-missense variants R192H R192S common but rare Europeans. Therefore, we aim investigate diabetes-associated genes, including R192H/S, with diabetes. Exome 80 Chinese patients (onset age < 35 years) after exclusion type 1 (T1D) were detected by customized gene panel covering 32 known genes....
The Atlantic sea nettle (<i>Chrysaora quinquecirrha</i>) has an important evolutionary position due to its high ecological value. However, limited sequencing technologies and complex jellyfish genomic sequences, the current <i>C. quinquecirrha</i> genome assembly is highly fragmented. Here, we used most advanced high-throughput chromosome conformation capture (Hi-C) technology obtain high-coverage data of genome. We then anchored these previously published contig-level improve Finally, a...