A5100650704- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Cell death mechanisms and regulation
- Estrogen and related hormone effects
- Drug Transport and Resistance Mechanisms
- Caveolin-1 and cellular processes
- Immune cells in cancer
- PARP inhibition in cancer therapy
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Lymphoma Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Cell Adhesion Molecules Research
- RNA Research and Splicing
- Natural Compounds in Disease Treatment
- Colorectal Cancer Treatments and Studies
- Cholesterol and Lipid Metabolism
- interferon and immune responses
- RNA regulation and disease
- Cholangiocarcinoma and Gallbladder Cancer Studies
Central South University
2014-2024
Xiangya Hospital Central South University
2014-2024
University of Chinese Academy of Sciences
2023
Beijing University of Technology
2023
Army Medical University
2009-2023
Daping Hospital
2023
Ruijin Hospital
2003-2021
Soochow University
2021
Nanjing Medical University
2020
Nanjing University
2019
Abstract The cGAS-STING signaling pathway has emerged as a critical mediator of innate immune responses, playing crucial role in improving antitumor immunity through effector responses. Targeting the holds promise for overcoming immunosuppressive tumor microenvironments (TME) and promoting effective elimination. However, systemic administration current STING agonists faces challenges related to low bioavailability potential adverse effects, thus limiting their clinical applicability....
We conducted a meta-analysis to evaluate the efficacy of anti-programmed cell death 1 (PD-1)/programmed ligand (PD-L1) monotherapy or immunotherapy combined with chemotherapy and further estimated value PD-L1 expression in predicting response from anti-PD-1/PD-L1 treatments as combination chemotherapy.Clinical trial data were searched electronic databases, which evaluated PD-1/PD-L1 inhibitors non-small lung cancer (NSCLC) correlated levels.Fifteen randomized-controlled trials involving...
PTEN plays an essential role in tumorigenesis and both its mutation inactivation can influence proliferation, apoptosis, cell cycle progression tumor cells. However, the precise of lung cancer cells has not been well studied. To address this, we have generated adenocarcinoma A549 overexpressing wild-type or mutant as expressing a siRNA directed toward endogenous . Overexpression profoundly inhibited promoted caused arrest at G1, downregulated p-AKT, decreased expression telomerase protein...
Background: LncRNAs have been shown to play essential roles in cancer therapeutic response. However, the detailed mechanism of lncRNAs temozolomide (TMZ) resistance glioblastoma (GBM) remain be elucidated. Methods: To elucidate maintaining TMZ resistance, we constructed two TMZ-resistant GBM cell lines (T98G-R/U118-R). from four public datasets were reanalyzed, and candidate lncRNA ADAMTS9-AS2 was evaluated TMZ-treated patients vitro lines. Results: Reanalysis expression profiles identified...
Abstract Osteoarthritis (OA) is a common articular degenerative disease characterized by loss of cartilage matrix and subchondral bone sclerosis. Kartogenin (KGN) has been reported to improve chondrogenic differentiation mesenchymal stem cells. However, the therapeutic effect KGN on OA-induced degeneration was still unclear. This study aimed explore protective effects underlying mechanisms degradation using mice with post-traumatic OA. To mimic in vivo arthritic environment, vitro cultured...
Abstract Temozolomide (TMZ) represents a standard-of-care chemotherapeutic agent in glioblastoma (GBM). However, the development of drug resistance constitutes significant hurdle treatment malignant glioma. Although specific innovative approaches, such as immunotherapy, have shown favorable clinical outcomes, inherent invasiveness most gliomas continues to make them challenging treat. Consequently, there is an urgent need identify effective therapeutic targets for overcome chemoresistance...
Glioma is a highly malignant brain tumor with poor survival rate. Novel biomarkers that act as prompt indicators of glioma are urgently needed. In this study, we identified and validated prognosis-related differentially expressed genes by datasets in the GEO TCGA databases. Ferroptosis newly recognized process cell death playing vital role cancer biology. Pearson correlation coefficient were used to discovery which have highest ferroptosis. Matrix remodeling-associated protein 8 (MXRA8) was...
Lung adenocarcinoma (LUAD) is the most common histological form of lung cancer that clinically diagnosed. The aim this study to explore novel genes associated with LUAD tumorigenesis. Comprehensive bioinformatics analyses data were obtained from several publicly available databases, such as Gene Expression Omnibus, Human Protein Atlas project, and Cancer Cell Line Encyclopedia. clinical relevance these in was further examined by immunohistochemistry. We identified overlapping differentially...
Premature ovarian failure (POF), an disorder of multifactorial origin, is defined as the occurrence amenorrhea, hypergonadotropism and hypoestrogenism in females <40 years old. Apoptosis granulosa cells important POF understanding regulatory mechanism underlying cell apoptosis may be beneficial for management POF. Increasing evidence suggests that microRNAs (miRs) have a function oocyte maturation follicular development. In present study, expression miR‑146a plasma obtained from patients...
Chronic obstructive pulmonary disease (COPD) is a debilitating caused by chronic exposure to cigarette smoke (CS). Celastrol pentacyclic triterpenoid compound exhibits potent antioxidant and anti-inflammatory activities. Also it presently known protect against liver damage induced type II diabetes. However, its role in COPD unclear. In this study, we investigated the effects of on cellular inflammation mice exposed CS Beas-2B cells treated with extract (CSE). C57BL/6 were randomly divided...
Ferroptosis, a distinct type of regulated cell death, has been reported to be involved in the tumorigenesis liver hepatocellular carcinoma (LIHC). However, precise functions and potential mechanisms ferroptosis LIHC were still poorly understood. Herein, we investigated biological roles ferroptosis-related gene STEAP3 LIHC. was previously proved serve key regulator via mediating iron metabolism. Comprehensive bioinformatics from several databases revealed that significantly downregulated...
Previous study found that rifampicin caused intrahepatic cholestasis. This investigated the effects of on hepatic lipid metabolism. Mice were orally administered with (200 mg/kg) daily for different periods. Results showed serum TG level was progressively reduced after a short elevation. By contrast, content markedly increased in rifampicin-treated mice. An obvious accumulation, as determined by Oil Red O staining, observed mice treated more than one week. Moreover, mRNA levels Fas, Acc and...
Background: Studies have increasingly shown that carbamoyl phosphate synthetase 1 (CPS1) plays a vital role in the occurrence and development of human malignant disease. Unfortunately, detailed function CPS1 prognosis lung cancer, especially adenocarcinoma (LADC), is still not fully understood. In this research, we performed comprehensive bioinformatics analysis with respect to LADC. Methods: Several biological databases including UALCAN, GEPIA Oncomine were used analyze expression...
Triple-negative breast cancer (TNBC) is a clinically aggressive subtype of commonly resistant to therapeutics that have been successful in increasing survival patients with estrogen receptor-positive (ER(+)) and HER2(+) cancer. As such, identifying factors contribute poor patient outcomes mediate the growth TNBC cells remain important areas investigation. MTBP (MDM2-binding protein), gene linked cellular proliferation transcriptional target MYC oncogene, overexpressed human malignancies, yet...
OBJECTIVE: Sirtuins (SIRT) are NAD+-dependent protein deacetylases that involved in the regulation of cancer-associated pathways. However, biological role these remains elusive glioblastoma (GBM). Here, we evaluated effects 7 sirtuins regarding their occurrence and prognostic value for GBM. METHODS: In this research, SIRT5 on prognosis GBM were using integrative bioinformatics analyses. RESULTS: Based comprehensive analyses data obtained from web-based platforms, demonstrate only expression...
Basal phenotype breast cancer is one of the most aggressive cancers that frequently metastasize to brain. The role sex hormones and their receptors in development this disease largely unclear. We demonstrated mPR α was expressed at a moderate level brain metastatic BPBC cell line MB231Br, which derived from parent undetectable MB231 cells. It functioned as an essential mediator for progesterone induced inhibitory effects on migration MB231Br and, when coincubated with PP1, synergistically...
Airway mucus hypersecretion is a major pathological characteristic of chronic obstructive pulmonary disease (COPD), and cigarette smoke highly implicated in secretion the development COPD. Cigarette reportedly induces mucin overproduction through epidermal growth factor receptor (EGFR) airway epithelium; however, underlying mechanisms responsible for activation EGFR remain unknown. Caveolin-1, component protein cytomembrane, regulates inflammation lung injury. In this study, we aimed to...