A5101768087- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Cancer-related molecular mechanisms research
- Peripheral Artery Disease Management
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Lung Cancer Research Studies
- Microtubule and mitosis dynamics
- Peptidase Inhibition and Analysis
- RNA Research and Splicing
- Lung Cancer Diagnosis and Treatment
- MicroRNA in disease regulation
- Protein Degradation and Inhibitors
- Cancer therapeutics and mechanisms
- Bioinformatics and Genomic Networks
- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Healthcare and Environmental Waste Management
- Dental Research and COVID-19
- Chromatin Remodeling and Cancer
- Neuroendocrine Tumor Research Advances
- Blood Pressure and Hypertension Studies
- Autoimmune and Inflammatory Disorders Research
Qilu Hospital of Shandong University
2019-2024
Bengbu Medical College
2023
Second Hospital of Shandong University
2023
Sichuan University
2021-2023
Northwest A&F University
2023
Nankai University
2023
Southeast University
2019-2022
University of Pennsylvania
2019-2022
West China Hospital of Sichuan University
2021
Taiyuan Central Hospital
2019-2020
We conducted a meta-analysis to evaluate the efficacy of anti-programmed cell death 1 (PD-1)/programmed ligand (PD-L1) monotherapy or immunotherapy combined with chemotherapy and further estimated value PD-L1 expression in predicting response from anti-PD-1/PD-L1 treatments as combination chemotherapy.Clinical trial data were searched electronic databases, which evaluated PD-1/PD-L1 inhibitors non-small lung cancer (NSCLC) correlated levels.Fifteen randomized-controlled trials involving...
Men of predominantly African Ancestry (AA) have higher prostate cancer (CaP) incidence and worse survival than men European (EA). While socioeconomic factors drive this disparity, genomic may also contribute to differences in the mortality rates. To compare prevalence tumor alterations transcriptomic profiles by patient genetic ancestry, we evaluated from The Cancer Genome Atlas (TCGA) CaP cohort (n = 498). Patient global local ancestry were estimated computational algorithms using...
Abstract A growing emphasis in anticancer drug discovery efforts has been on targeting histone acetylation modulators. Here we comprehensively analyze the genomic alterations of genes encoding modulator proteins (HAMPs) Cancer Genome Atlas cohort and observe that HAMPs have a high frequency focal copy number recurrent mutations, whereas transcript fusions are relatively rare events common adult cancers. Collectively, 86.3% (63/73) at least 1 cancer type 16 HAMPs, including 9 understudied...
By combining 6 druggable genome resources, we identify 6,083 genes as potential (PDGs). We characterize their expression, recurrent genomic alterations, cancer dependencies, and therapeutic potentials by integrating genome, functionome, druggome profiles across cancers. 81.5% of PDGs are reliably expressed in major adult cancers, 46.9% show selective expression patterns, 39.1% exhibit at least one alteration. annotate a total 784 dependent for cell growth. further quantify 16 cancer-related...
Background The efficacy of adjuvant chemotherapy in patients with 8th edition stage IB (tumor size ≤4 cm) non-small cell lung cancer (NSCLC) remains unclear. Methods We identified 9757 eligible (non-chemotherapy group: n=8303; n=1454) between 2004 and 2016 from the Surveillance, Epidemiology End Results (SEER) database. Log-rank test was used to compare overall survival (OS) non-chemotherapy groups. Cox regression model applied investigate independent prognosis factors all surgically treated...
Recurrent copy-number alterations, mutations, and transcript fusions of the genes encoding CDKs/cyclins are characterized in >10,000 tumors. Genomic alterations dominantly driven by copy number aberrations. In contrast to cell-cycle-related CDKs/cyclins, which globally amplified, transcriptional recurrently lose numbers across cancers. Although mutations relatively rare events, CDK12 exhibits recurrent multiple Among CDKs, CDK7 show most significant loss mutation, respectively. Their genomic...
Abstract Cervical cancer (CC) is the most frequently diagnosed genital tract in females worldwide. Rac GTPase-activating protein 1 (RacGAP1) one of specific proteins. As a novel tumor protooncogene, overexpression RacGAP1 was related to occurrence various tumors, but its function CC still unclear. In this study, bioinformatics analyses showed that might be key candidate gene progression CC. significantly overexpressed tissues. High expression positively associated with poor prognosis....
Pleural effusion is a common presentation in clinical practice. About 40% of exudative pleural unable to be diagnosed through thoracentesis, and closed biopsy (CPB) needed. This study was designed investigate the diagnostic yield CPB effusion.This retrospective 10-year patients with unexplained who underwent two centers. Malignant (MPE) when there histopathological evidence tissue, pulmonary or fluid. Tuberculous (TPE) confirmed granuloma coagulative necrosis observed Ziehl-Neelsen acid-fast...
Abstract Idiopathic pulmonary fibrosis (IPF) is a devastating fibrotic lung disease characterized by scarring and destruction of the architecture, with limited treatment options. Targeted gene therapy to restore cell division autoantigen-1 (CDA1) expression may be potential approach delay progression (PF). Here, we focused on CDA1, which was significantly decreased in human IPF, mouse model bleomycin (BLM)-induced PF, transforming growth factor (TGF-β)-challenged fibroblasts. In vitro, CDA1...
Endovascular treatment (EVT) is advocated for acute ischaemic stroke with large-vessel occlusion (LVO), but perioperative periods are challenging. This study investigated the relationship between post-EVT short-term blood pressure variability (BPV) and early outcomes in LVO patients.We retrospectively reviewed 72 patients undergoing EVT June 2015 2018. Hourly systolic diastolic pressures (SBP DBP, respectively) were recorded first 24 h post-EVT. BPV evaluated as standard deviation (SD),...
The main aim of this study was to evaluate the efficiency second-line chemotherapy irinotecan (CPT-11), topotecan (TPT), paclitaxel (PTX) and docetaxel (DTX) in small cell lung cancer (SCLC) patients who have failure first-line standard treatment. secondary independent prognostic factors received a second line treatment.Retrospective analysis 116 chemotherapy. Patients were divided into 4 groups according therapy they treated with, which CPT-11, TPT, PTX DTX. Progress free survival (PFS),...
Objectives Stroke survivors require assistance and support in their daily lives. This survey aims to investigate the needs rights awareness Chinese stroke caregivers rural urban settings. Setting was adapted from one created by World Organization. The questionnaire included demands for psychological support, treatment care, social information. From January 2015 2016, pilot tested with rural-dwelling 12 hospitals. were invited participate if they over 18 years old had experienced a stroke....
Abstract PDIA6 have been reported to be involved in a variety of cancers, however, the underlying role endometrial cancer is still unclear. In this study, we aimed study function cancer. Firstly, verified that was significantly upregulated cancer, which correlated with progression patients. Furthermore, identified altered ability cells proliferate and metastasize. addition, our result illustrated oncogene effects promoting malignant biological behavior by regulating TGF-β pathway being...
Aim: To determine whether lymphadenectomy is associated with increased survival of women stage IA endometrial cancer. Methods: Patients diagnosed cancer from 2004 to 2013 and whose clinicopathologic data were recorded in the SEER database examined. Propensity matching paired subjects similar background variables. Before after matching, Kaplan-Meier curves drawn for comparison. Results: In 11,603 patients, cardiovascular disease diabetes most common causes death. significantly improved...
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Abstract Objective The Chinese stroke emergency map ( SEM ) was implemented in 2017 to reduce prehospital and hospital delays for acute ischemic (AIS) patients suitable intravenous recombinant tissue plasminogen activator (rt‐PA) thrombolysis. However, data on the time delay following implementation of an China are limited. Methods Data suspected from registry center Taiyuan, Shanxi Province, August July 2019, patients’ characteristics, thrombolysis rate, functional outcome at 90 days were...