A5049218164- Cancer-related molecular mechanisms research
- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Developmental Biology and Gene Regulation
- Spinal Hematomas and Complications
- Hippo pathway signaling and YAP/TAZ
- Neuroinflammation and Neurodegeneration Mechanisms
- Pluripotent Stem Cells Research
- Prostate Cancer Diagnosis and Treatment
- Adenosine and Purinergic Signaling
- TGF-β signaling in diseases
- Neuropeptides and Animal Physiology
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Animal Genetics and Reproduction
- Anesthesia and Pain Management
- ATP Synthase and ATPases Research
- Bioinformatics and Genomic Networks
- Mitochondrial Function and Pathology
- Genomics and Chromatin Dynamics
- MicroRNA in disease regulation
- Chemokine receptors and signaling
- Protein Degradation and Inhibitors
- Pain Mechanisms and Treatments
- Prostate Cancer Treatment and Research
Nanchang University
2018-2023
First Affiliated Hospital of Nanchang University
2018-2023
University of Pennsylvania
2020-2022
Nanjing Medical University
2019
Jilin Medical University
2018
Jilin University
2018
University of Chicago
2012
New York University
2001-2005
Men of predominantly African Ancestry (AA) have higher prostate cancer (CaP) incidence and worse survival than men European (EA). While socioeconomic factors drive this disparity, genomic may also contribute to differences in the mortality rates. To compare prevalence tumor alterations transcriptomic profiles by patient genetic ancestry, we evaluated from The Cancer Genome Atlas (TCGA) CaP cohort (n = 498). Patient global local ancestry were estimated computational algorithms using...
By combining 6 druggable genome resources, we identify 6,083 genes as potential (PDGs). We characterize their expression, recurrent genomic alterations, cancer dependencies, and therapeutic potentials by integrating genome, functionome, druggome profiles across cancers. 81.5% of PDGs are reliably expressed in major adult cancers, 46.9% show selective expression patterns, 39.1% exhibit at least one alteration. annotate a total 784 dependent for cell growth. further quantify 16 cancer-related...
The establishment of expression domains developmentally regulated genes depends on cues provided by different concentrations transcriptional activators and repressors. Here we analyze the regulation Drosophila gene zen , which is a target Decapentaplegic (Dpp) signaling pathway during cellular blastoderm formation. We show that low levels Dpp signal transducer p-Mad (phosphorylated Mad), together with recently discovered negative regulator Brinker (Brk), define spatial limits transcription...
Abstract Background This study aims to investigate the role of long non-coding RNA Gm14461 in regulating pain transmission trigeminal neuralgia (TN). The mouse TN model was produced by chronic constriction injury infraorbital nerve (CCI-ION). values mechanical withdrawal threshold (MWT) were measured assess nociception mice at different times after CCI-ION surgery (0, 1, 3, 5, 7, 9, 11, 13, 15 d). primary ganglion neurons (TGNs) isolated from C57BL/6 J and treated with TNF-α mimic a cellular...
Gradients of morphogens determine cell fates by specifying discrete thresholds gene activities. In the Drosophila embryo, a BMP gradient subdivides dorsal ectoderm into amnioserosa and epidermis, also inhibits neuroectoderm formation. A number genes are differentially expressed in response to gradient, but how their borders expression established is not well understood. We present evidence that via Smads, provides two-fold input regulating amnioserosa-specific target such as Race. Peak...
Abstract Most cancer cells perform glycolysis despite having sufficient oxygen. The specific metabolic pathways of have become the focus treatment. Recently, accumulating evidence indicates oxidative phosphorylation (OXPHOS) and can be regulated with each other. Thus, we suggest that is inhibited by restoring or improving OXPHOS in cells. In our study, found oxaloacetate (OA) induced apoptosis HepG2 vivo vitro. Meanwhile, OA a decrease energy metabolism Further results showed expression...
Pattern formation in the developing embryo relies on key regulatory molecules, many of which are distributed concentration gradients. For example, a gradient BMP specifies cell fates along dorsoventral axis species ranging from flies to mammals. In Drosophila, molecule Dpp gives rise nested domains target gene expression dorsal region embryo; however, mechanisms underlying differential response not well understood, partly owing an insufficient number well-studied targets. Here we analyze how...
Objective To observe the surgical procedure and outcome of percutaneous endoscopic lumbar discectomy for L5/S1 disc herniation (LDH) by interlaminar transforaminal approach.Methods A total 153 patients with LDH who were treated using (PETD, n = 84) or (PEID, 69) from January 2016 to 2018 enrolled in this retrospective study. The time puncture, operation under endoscope, number fluoroscopy two groups compared. All followed up years Oswestry disability index (ODI) Visual Analogue Scale (VAS)....
Abstract Our previous study showed that silencing of lncRNA Gm14461 alleviated pain in a murine model trigeminal neuralgia (TN), but the molecular mechanism remains not fully understood. Evidence indicates astrocyte activation and autophagy are involved development TN. Herein, this aimed to elucidate whether pain‐relief effect TN regulation autophagy. A was induced by chronic constriction injury infraorbital nerve surgery. The mechanical withdrawal threshold (MWT) measured assess analgesic...
To investigate the clinical efficacy of transforaminal endoscopic discectomy (TED) in treating recurrent lumbar disc herniation.Clinical datal 31 patients who were hospitalized Department Pain Management, First Affiliated Hospital Nanchang University, between 2015 and 2018 due to herniation collected analyzed retrospectively. Visual analogue scale (VAS) scores Japanese Orthopedic Association (JOA) used assess alterations patients' leg pain intensity nerve function, respectively. The Modified...
Purpose: To date, increasing evidences have demonstrated that the aberrant expression of miR-371–3 cluster has been verified in various cancers and could be potentially used as a biomarker for tumor diagnosis prognosis. explore role prognosis, we conducted this study based on published data. Methods: We searched electronic databases (PubMed, EMBASE Web Science databases) (Jan 1, 2007 to Jun 2018). The pooled sensitivity, specificity area under curve (AUC) summary receiver operator...
Abstract Purpose To investigate the clinical efficacy of transforaminal endoscopic discectomy in treating recurrent lumbar disc herniation. Methods Clinical datal 31 patients who were hospitalized Department Pain Management, First Affiliated Hospital Nanchang University, between 2015 and 2018 due to herniation collected analyzed retrospectively. Visual analogue scale (VAS) scores Japanese Orthopedic Association (JOA) used assess alterations patients’ pain intensity nerve function,...