A5043840392- Algebraic Geometry and Number Theory
- Algebraic structures and combinatorial models
- Homotopy and Cohomology in Algebraic Topology
- Advanced Algebra and Geometry
- Geometry and complex manifolds
- CRISPR and Genetic Engineering
- Protein Degradation and Inhibitors
- Nonlinear Waves and Solitons
- Cancer Genomics and Diagnostics
- Genomics and Chromatin Dynamics
- Cancer Research and Treatments
- Cancer-related gene regulation
- Cancer-related Molecular Pathways
- Periodontal Regeneration and Treatments
- Cancer, Hypoxia, and Metabolism
- Bioinformatics and Genomic Networks
- Geometric and Algebraic Topology
- RNA Research and Splicing
- Advanced Combinatorial Mathematics
- Polyomavirus and related diseases
- Click Chemistry and Applications
- Ferroptosis and cancer prognosis
- Botulinum Toxin and Related Neurological Disorders
- Ectopic Pregnancy Diagnosis and Management
- Genomic variations and chromosomal abnormalities
University of Pennsylvania
2012-2024
The Ohio State University
2024
AstraZeneca (United States)
2024
Bioscience Research
2024
Stomatology Hospital
2009-2024
Guangzhou Medical University
2024
Sun Yat-sen University
2006-2022
Shanghai Jiao Tong University
2017
Shandong University
2010-2017
Shanghai Mental Health Center
2017
PARP inhibitors can be combined with BET to treat cancers de novo or acquired resistance inhibition.
Men of predominantly African Ancestry (AA) have higher prostate cancer (CaP) incidence and worse survival than men European (EA). While socioeconomic factors drive this disparity, genomic may also contribute to differences in the mortality rates. To compare prevalence tumor alterations transcriptomic profiles by patient genetic ancestry, we evaluated from The Cancer Genome Atlas (TCGA) CaP cohort (n = 498). Patient global local ancestry were estimated computational algorithms using...
Abstract A growing emphasis in anticancer drug discovery efforts has been on targeting histone acetylation modulators. Here we comprehensively analyze the genomic alterations of genes encoding modulator proteins (HAMPs) Cancer Genome Atlas cohort and observe that HAMPs have a high frequency focal copy number recurrent mutations, whereas transcript fusions are relatively rare events common adult cancers. Collectively, 86.3% (63/73) at least 1 cancer type 16 HAMPs, including 9 understudied...
By combining 6 druggable genome resources, we identify 6,083 genes as potential (PDGs). We characterize their expression, recurrent genomic alterations, cancer dependencies, and therapeutic potentials by integrating genome, functionome, druggome profiles across cancers. 81.5% of PDGs are reliably expressed in major adult cancers, 46.9% show selective expression patterns, 39.1% exhibit at least one alteration. annotate a total 784 dependent for cell growth. further quantify 16 cancer-related...
In human cancer, expression of the let-7 family is significantly reduced, and this associated with shorter survival times in patients. However, mechanisms leading to downregulation cancer are still largely unclear. Since an alteration copy-number one causes gene deregulation we examined copy number alterations 2,969 specimens from a high-resolution SNP array dataset. We found that there was reduction genes cancer-type specific manner. Importantly, focal deletion four members three types:...
Apigenin, a common dietary flavonoid, has been shown to possess anti‐tumor properties. However, the mechanism by which apigenin inhibits cancer cells is not fully understood. Id1 (inhibitor of differentiation or DNA binding protein 1) contributes tumorigenesis stimulating cell proliferation, inhibiting and facilitating tumor neoangiogenesis. Elevated found in ovarian cancers its level correlates with malignant potential tumors. Therefore, target for treatment. Here, we demonstrate that...
Recurrent copy-number alterations, mutations, and transcript fusions of the genes encoding CDKs/cyclins are characterized in >10,000 tumors. Genomic alterations dominantly driven by copy number aberrations. In contrast to cell-cycle-related CDKs/cyclins, which globally amplified, transcriptional recurrently lose numbers across cancers. Although mutations relatively rare events, CDK12 exhibits recurrent multiple Among CDKs, CDK7 show most significant loss mutation, respectively. Their genomic...
// Xiaowen Hu 1 , Yang Liu 3 Changmei Wang 2 Lulu Hou Xiaoyan Zheng Yeqiu Xu Lin Ding and Shuguang Pang Department of Infectious Diseases, Jinan Central Hospital Affiliated to Shandong University, 250013, China Endocrinology, School Chemistry Molecular Biosciences, The University Queensland, St Lucia Qld 4072, Australia Correspondence to: Pang, email: shuguangpang@163.com Keywords: metformin; thyrotropin; free triiodothyronine; thyroxine; type diabetes Received: June 26, 2017 Accepted:...
For smooth complete intersections in the projective spaces, we use deformation invariance of Gromov-Witten invariants and results classical invariant theory to study symmetric reduction WDVV equation by monodromy groups. genus 0 non-exceptional Fano other than cubic hypersurfaces, find a square root recursion phenomenon. Based on this develop an algorithm compute any lengths with number primitive insertions. The effectivity our even dimension, its validity odd dimensions for more...
For local Calabi-Yau manifolds which are total spaces of vector bundle over balloon manifolds, we propose a formal definition reduced Genus one Gromov-Witten invariants, by assigning contributions from the refined decorated rooted trees. We show that this satisfies localized version standard versus formula, whose global in compact cases is due to A. Zinger. As an application prove conjecture previous article on genus invariants concave splitting bundles projective spaces. In particular,...
An “induced PARP inhibitor (PARPi) sensitivity by epigenetic modulation” strategy is being evaluated in the clinic to sensitize homologous recombination (HR)-proficient tumors PARPi treatments. To expand its clinical applications and identify more efficient combinations, we performed a drug screen combining with 74 well-characterized modulators that target five major classes of enzymes. Both type I PRMT PRMT5 exhibit high combination priority scores our screen. inhibition significantly...
The nuclear receptor (NR) superfamily is one of the major druggable gene families, representing targets approximately 13.5% approved drugs. Certain NRs, such as estrogen and androgen receptor, have been well demonstrated to be functionally involved in cancer serve informative biomarkers therapeutic oncology. However, spectrum NR dysregulation across cancers remains comprehensively characterized. Through computational integration genetic, genomic, pharmacologic profiles, we characterized...
An "induced PARP inhibitor (PARPi) sensitivity by epigenetic modulation" strategy is being evaluated in the clinic to sensitize homologous recombination (HR)-proficient tumors PARPi treatments. To expand its clinical applications and identify more efficient combinations, we performed a drug screen combining with 74 well-characterized modulators that target five major classes of enzymes. Both type I PRMT PRMT5 exhibit high combination priority scores our screen. inhibition significantly...
TMJ morphology/position and trabecular structure are influenced by various factors. The role of the interincisal angle, an indicator anterior occlusal relationship, on remains unclear. This study aims to investigate morphology, bone structure, position condyle, as well glenoid fossa's morphology in skeletal class II populations with different angles.
We show that in a smooth family of complete varieties, the existence full exceptional collection on fiber preserves for fibers neighborhood. Then we noncommutative deformations strong vector bundles induce same map second Hochschild cohomology as canonical isomorphism induced by derived equivalence to corresponding endomorphism algebra.
We state a version of the crepant resolution conjecture for total ancestor potentials surface singularities, and reduce to quantum McKay correspondence J.Bryan A.Gholampour vanishing Hurwitz-Hodge integrals. In particular, singularities type A, we prove conjecture. also suggest an approach towards proof general cases by Teleman's reconstruction theorem semisimple cohomological field theories.
We conjecture a formula for the generating function of genus one Gromov-Witten invariants local Calabi-Yau manifolds which are total spaces splitting bundles over projective spaces. prove this in several special cases, and assuming validity our we check integrality BPS numbers 5-folds defined by A. Klemm R. Pandharipande.