Nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2)-induced oxidative stress, including the production of reactive oxygen species (ROS) and hydrogen peroxide, plays a pivotal role in neuropathic pain. Although activation plasma membrane translocation protein kinase C (PKC) isoforms dorsal root ganglion (DRG) neurons have been implicated multiple pain models, interactions between NOX2-induced stress PKC remain unknown.A spared nerve injury (SNI) model was established adult male rats....

Comorbid anxiodepressive-like symptoms (CADS) in chronic pain are closely related to the overactivation of lateral habenula (LHb). Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels have been implicated play a key role regulating neuronal excitability. However, HCN LHb during CADS has not yet characterized. This study aimed investigate effect on pain.

Abstract Background This study aims to investigate the role of long non-coding RNA Gm14461 in regulating pain transmission trigeminal neuralgia (TN). The mouse TN model was produced by chronic constriction injury infraorbital nerve (CCI-ION). values mechanical withdrawal threshold (MWT) were measured assess nociception mice at different times after CCI-ION surgery (0, 1, 3, 5, 7, 9, 11, 13, 15 d). primary ganglion neurons (TGNs) isolated from C57BL/6 J and treated with TNF-α mimic a cellular...

The thalamocortical (TC) circuit is closely associated with pain processing. hyperpolarization-activated cyclic nucleotide-gated (HCN) 2 channel predominantly expressed in the ventral posterolateral thalamus (VPL) that has been shown to mediate neuropathic pain. However, role of VPL HCN2 modulating TC activity largely unknown. Here, by using optogenetics, neuronal tracing, electrophysiological recordings, and virus knockdown strategies, we showed activation neurons potentiates excitatory...

Forkhead box O1 (FoxO1) is a critical molecule in modulating cell growth, differentiation and metabolism, acting as vital transcription factor. This study explored the role of FoxO1 chronic constriction injury (CCI)-induced neuropathic pain (NP). Microglial astrocyte activation was achieved with lipopolysaccharide (LPS, 100 ng/mL) to establish an in-vitro NP model. Morphological alterations LPS-induced microglia astrocytes were assayed by light microscopy. The levels inflammatory cytokines...

Objective To observe the surgical procedure and outcome of percutaneous endoscopic lumbar discectomy for L5/S1 disc herniation (LDH) by interlaminar transforaminal approach.Methods A total 153 patients with LDH who were treated using (PETD, n = 84) or (PEID, 69) from January 2016 to 2018 enrolled in this retrospective study. The time puncture, operation under endoscope, number fluoroscopy two groups compared. All followed up years Oswestry disability index (ODI) Visual Analogue Scale (VAS)....

Abstract Our previous study showed that silencing of lncRNA Gm14461 alleviated pain in a murine model trigeminal neuralgia (TN), but the molecular mechanism remains not fully understood. Evidence indicates astrocyte activation and autophagy are involved development TN. Herein, this aimed to elucidate whether pain‐relief effect TN regulation autophagy. A was induced by chronic constriction injury infraorbital nerve surgery. The mechanical withdrawal threshold (MWT) measured assess analgesic...

To investigate the clinical efficacy of transforaminal endoscopic discectomy (TED) in treating recurrent lumbar disc herniation.Clinical datal 31 patients who were hospitalized Department Pain Management, First Affiliated Hospital Nanchang University, between 2015 and 2018 due to herniation collected analyzed retrospectively. Visual analogue scale (VAS) scores Japanese Orthopedic Association (JOA) used assess alterations patients' leg pain intensity nerve function, respectively. The Modified...

Objective. To study the effect of pulsed radio frequency (PRF) on nerve repair and expression GFAP GDNF in rats with neuropathic pain. Methods. Thirty SPF healthy SD were randomly divided into control group (Group C), PSNL (partial ligation sciatic nerve) + sham PS), PRF PR), 10 each group. In C, right was exposed without ligation. PS group, model pain established by partial nerve. The mice PR treated after establishing model. general behavior during treatment observed. mechanical thermal...

Abstract Background The cardiac magnetic resonance tissue tracking (CMR-TT) technique was used to obtain left atrial strain and rate in patients with myocardial infarction (MI) evaluate the utility of this quantitative assessment for distinguishing acute from chronic infarction. Methods We retrospectively analyzed 36 consecutive (AMI) 29 (CMI) who underwent CMR 30 controls. Left (LA) ventricular functions were quantified by volumetric, CMR-TT derived analysis long short view cines. Receiver...

This study explored the 10-year efficacy, safety, and prognostic factors of low-dose collagenase chemonucleolysis (CCNL) combined with radiofrequency (RF) in treatment lumbar disc herniation (LDH).The data 167 LDH patients were collected. Modified MacNab criteria, Numerical Rating Scale (NRS), Japanese Orthopedic Association (JOA) scores were, respectively, used to evaluate patients' excellent good rates, pain degree, nerve function. The preoperative postoperative pain, numbness, muscle...

Airway inflammation is a key feature of chronic obstructive pulmonary disease (COPD) and inhaled corticosteroids (ICS) remain the main treatment for airway inflammation. Studies have noted increased efficacy ICS long-acting beta 2 agonist (LABA) combination therapy in controlling exacerbations improving than either monotherapy. Further studies suggested that LABAs may inherent anti-inflammatory potential, but this has not been well-studied.We hypothesize LABA olodaterol can inhibit resulting...

Background Sciatica (neuropathic pain [NP]) is a common disease characterized by from radiation along the sciatic nerve. The aim of this study was to genes associated with chronic systolic injury nerve (SCN-CCI) in rats RNA-Seq technique, and explore their potential as therapeutic targets. Methods Sciatic rat model obtained ligation divided into two groups: SCN-CCI group Sham group. Behavioral assessments were performed evaluate sensitivity, following which spinal cord dorsal horn resected...

<title>Abstract</title> <bold>OBJECTIVE</bold>: This study aimed to investigate the changes in resting-state functional connectivity (rsFC) of sensorimotor network(SMN) patients with herpes zoster(HZ) and postherpetic neuralgia patients(PHN). Then, We applied machine learning distinguish PHN/HZ from healthy controls(HC). <bold>METHODS</bold>: HZ (n=53), PHN (n=57), HC (n=50) were included, magnetic resonance imaging (rs-fMRI) was performed on them. Seed-based ROI-to-ROI analyses evaluate...

The mechanism of pyroptosis in trigeminal neuralgia (TN) progression remains unclear. discovery tRNA-derived small RNAs (tsRNAs) the is a breakthrough. We aim to study whether tsRNA involved TN through pyroptosis. A rat model was constructed by chronic constriction injury infraorbital nerve and then mechanical hyperalgesia quantitated using withdrawal threshold test. Mechanical significantly elevated injury. Immunofluorescence revealed that expression GSDMD NLRP3 were enhanced rats....

Substantia gelatinosa (SG) neurons, which are located in the spinal dorsal horn (lamina II), have been identified as “central gate” for transmission and modulation of nociceptive information. Rebound depolarization (RD), a biophysical property mediated by membrane hyperpolarization that is frequently recorded central nervous system, contributes to shaping neuronal intrinsic excitability and, turn, output network function. However, electrophysiological morphological properties SG neurons...

To investigate and integrate multiple independent risk factors to establish a nomogram for predicting the unfavourable outcomes of percutaneous endoscopic transforaminal discectomy (PETD) lumbar disc herniation (LDH). From January 2018 December 2019, total 425 patients with LDH undergoing PETD were included in this retrospective study. All divided into development validation cohort at ratio 4:1. Univariate multivariate logistic regression analyses used associated clinical cohort, prediction...

Abstract Background The left atrial strain and rate in patients with myocardial infarction (MI) were measured using the cardiac magnetic resonance tissue tracking (CMR-TT) technique, its usefulness quantitative assessment of for differentiating between acute chronic was assessed. Methods Consecutive 36 AMI 29 CMI who underwent CMR retrospectively analyzed as well 30 controls. By analyzing from long short ventricular view cines CMR-TT, functions measured. Receiver operating...

Abstract Purpose To investigate the clinical efficacy of transforaminal endoscopic discectomy in treating recurrent lumbar disc herniation. Methods Clinical datal 31 patients who were hospitalized Department Pain Management, First Affiliated Hospital Nanchang University, between 2015 and 2018 due to herniation collected analyzed retrospectively. Visual analogue scale (VAS) scores Japanese Orthopedic Association (JOA) used assess alterations patients’ pain intensity nerve function,...