A5016677515- Renal Diseases and Glomerulopathies
- Vitamin D Research Studies
- Parathyroid Disorders and Treatments
- Systemic Lupus Erythematosus Research
- Dialysis and Renal Disease Management
- Paraquat toxicity studies and treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Immunodeficiency and Autoimmune Disorders
- Iron Metabolism and Disorders
- Platelet Disorders and Treatments
- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Neurological and metabolic disorders
- Inflammasome and immune disorders
- Pancreatitis Pathology and Treatment
- Eosinophilic Esophagitis
- Spinal Hematomas and Complications
- Gout, Hyperuricemia, Uric Acid
- Healthcare Systems and Public Health
- Erythropoietin and Anemia Treatment
- Pharmacological Effects and Toxicity Studies
- Genetic Associations and Epidemiology
- Cardiovascular Function and Risk Factors
- Renin-Angiotensin System Studies
- Chronic Kidney Disease and Diabetes
Guangxi Medical University
2012-2025
First Affiliated Hospital of GuangXi Medical University
2012-2025
First Affiliated Hospital of Nanchang University
2021
Nanchang University
2021
Importance Lupus nephritis is typically treated with intravenous cyclophosphamide, which associated serious adverse effects. Oral mizoribine may be an alternative for induction therapy of lupus nephritis. However, large-scale, long-term, randomized clinical studies are lacking. Objective To assess the efficacy and safety oral vs cyclophosphamide as Chinese patients Design, Setting, Participants This prospective, multicenter, parallel-group, open-label, phase 3 trial recruited class III,...
Significance Statement Genome-wide association studies have identified nearly 20 IgA nephropathy susceptibility loci. However, most nonsynonymous coding variants, particularly ones that occur rarely or at a low frequency, not been well investigated. The authors performed chip-based study of in 8529 patients with the disorder and 23,224 controls. They rare variant gene encoding vascular endothelial growth factor A (VEGFA) was significantly associated two-fold increased risk nephropathy, which...
Experimental studies showed that 25-hydroxy-vitamin D [25(OH)D] deficiency (defined as < 15 ng/ml) has been associated with CKD progression. Patients IgA nephropathy have an exceptionally high rate of severe 25(OH)D deficiency; however, it is not known whether this a risk factor for progression nephropathy. We conducted study to investigate the relationship between plasma level and certain clinical parameters renal histologic lesions in patients nephropathy, evaluate could be good prognostic...
Lupus nephritis (LN) is one of the most prevalent and serious complications SLE, with significant effects on patient renal survival. Although a large number genetic variants associated SLE have been identified, biomarkers that correlate LN are extremely limited. In this study, we performed comprehensive sequencing analysis whole MHC region in 1331 patients 1296 healthy controls validated independent associations another 950 1000 controls. We discovered five risk for within region, including...
Background: Peritoneal fibrosis is the primary reason that patients with end-stage renal disease (ESRD) have to cease peritoneal dialysis. Peritonitis caused by Gram-negative bacteria such as Escherichia coli (E. coli) were on rise. We had previously shown matrine inhibited formation of biofilm E. coli. However, role epithelial-mesenchymal transition (EMT) in mesothelial cells under chronic inflammatory conditions still unknown. Methods: cultured human (HPMCs) lipopolysaccharide (LPS) induce...
This study explored the 10-year efficacy, safety, and prognostic factors of low-dose collagenase chemonucleolysis (CCNL) combined with radiofrequency (RF) in treatment lumbar disc herniation (LDH).The data 167 LDH patients were collected. Modified MacNab criteria, Numerical Rating Scale (NRS), Japanese Orthopedic Association (JOA) scores were, respectively, used to evaluate patients' excellent good rates, pain degree, nerve function. The preoperative postoperative pain, numbness, muscle...
Objective To investigate about the development and correlative factors of left ventricular hypertrophy (LVH) in patients with peritoneal dialysis. Methods 89 were enrolled who had received regular dialysis for more than 6 months First Affiliated Hospital Guangxi Medical University from September 1st, 2012 to 2013. Exclusion criteria included a history peritonitis or other infections within 1 month, complicated acute heart failure, chronic obstructive pulmonary disease, cancer,...