A5101854127- Neurobiology and Insect Physiology Research
- Insect and Arachnid Ecology and Behavior
- Hepatitis B Virus Studies
- Autophagy in Disease and Therapy
- Acute Ischemic Stroke Management
- Insect and Pesticide Research
- Cancer-related gene regulation
- Insect-Plant Interactions and Control
- Circular RNAs in diseases
- Liver Disease Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Stroke Rehabilitation and Recovery
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Neurological Disease Mechanisms and Treatments
- Manufacturing Process and Optimization
- Curcumin's Biomedical Applications
- Advanced Decision-Making Techniques
- Immunotherapy and Immune Responses
- Insect behavior and control techniques
- Technology Assessment and Management
- Insect Resistance and Genetics
- Advanced Manufacturing and Logistics Optimization
- Evaluation and Optimization Models
- Collaboration in agile enterprises
Shandong University
2025
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2024
Chang'an University
2024
Guzhou Transportation Planning Survey & Design Academe (China)
2024
Impact
2024
Qiannan Normal College For Nationalities
2024
Tianjin University
2024
Tianjin Stomatological Hospital
2024
Hebei Medical University
2024
Xingtai People's Hospital
2024
Parvimonas micra (P. micra), an opportunistic oral pathogen associated with multiple cancers, has limited research on its role in squamous cell carcinoma (OSCC). This study shows that P. is enriched OSCC tissues and positively correlated tumor metastasis stages. infection promotes by inducing hypoxia/HIF-1α, glycolysis, autophagy. Mechanistically, surface protein TmpC binds to CKAP4, a receptor overexpressed OSCC, facilitating bacterial attachment invasion. interaction activates HIF-1α...
We showed that curcumin inhibited hepatitis B virus (HBV) replication and expression via reductions in covalently closed circular DNA-bound histone acetylation.Furthermore, siRNAs targeting HBV acted synergistically with curcumin, resulting enhanced inhibition of HBV.
HBV infection has been reported to trigger endoplasmic reticulum (ER) stress and initiate autophagy. However, how ER autophagy influence production remains elusive. Here, we studied the effect of tunicamycin (TM), an N-glycosylation inhibitor inducer, on replication secretion examined underlying mechanisms.Protein disulfide isomerase (an marker), microtubule-associated protein 1 light chain 3 beta autophagosome [AP] sequestosome-1 (a typical cargo for autophagic degradation) expression were...
In nature, plant-insect interactions occur in complex settings involving multiple trophic levels, often with species at each level.1Poelman E.H. From induced resistance to defence interactions.Entomol. Exp. Appl. 2015; 157: 11-17Google Scholar Herbivore attack of a host plant typically dramatically alters the plant's odor emission terms concentration and composition.2Aljbory Z. Chen M.-S. Indirect defense against insect herbivores: review.Insect Sci. 2018; 25: 2-23Google Scholar,3Mithöfer A....
Pheromone receptors (PRs) found in the antennae of male moths play a vital role recognition sex pheromones released by females. The fall armyworm (FAW), Spodoptera frugiperda, is notorious invasive pest, but its PRs have not been reported. In this report, six candidate (SfruOR6, 11, 13, 16, 56 and 62) suggested phylogenetic analysis were cloned, their tissue-sex expression profiles determined quantitative real-time PCR (qPCR). All genes except for SfruOR6 highly specifically expressed...
Moths rely on plant volatiles to locate appropriate plants for feeding and laying eggs. While extensive research has been conducted the global agricultural pests, Spodoptera frugiperda litura, their molecular mechanisms detecting remain mostly unknown. Here, we have demonstrated that nonanal, a common volatile, is attractive both virgin gravid females of two species. Second, identified conserved odorant receptor clade (SfruOR47 clade) primarily tuned nonanal. Finally, by three-dimensional...
Hepatitis B virus (HBV) reactivation is a major problem that must be overcome during chemotherapy for HBV-related hepatocellular carcinoma (HCC). However, the mechanism underlying chemotherapy-associated HBV still not fully understood, hindering development of improved HCC treatments. A meta-analysis was performed to assess risk transcatheter arterial chemoembolization (TACE). To investigate regulatory effects and mechanisms 5-FU on replication, an mouse model established by pAAV-HBV1.2...
// Yan-Mei Ji 1, * , Xue-Feng Zhou 2, Jun Zhang 3, Xiang Zheng 1 Sheng-Bao Li 4 Zhi-Qiang Wei 5 Tao Liu Dong-Liang Cheng 3 Ping 6 Kuncheng Song 7 Tan Hua Zhu Jia-Long Guo Department of Intensive Care Unit, Taihe Hospital, Hubei University Medicine, Shiyan, People's Republic China 2 Thoracic and Cardiovascular Surgery, Zhongnan Hospital Wuhan University, Wuhan, Cardiothoracic Gastroenterology, Institute Biomedical Research, Pathology, Davis Heart Lung Research Institute, The Ohio State Wexner...
Hepatitis B virus (HBV) particles are thought to be secreted from hepatocytes through multivesicular bodies (MVBs); however, the cellular trafficking mechanisms prior this process remain elusive. It has been reported that CCDC88A/GIV expression, which is involved in multiple aspects of vesicular trafficking, changes dynamically at different phases chronic HBV infection. In study, we focused on role replication. liver tissues chronically HBV-infected patients, infection significantly enhanced...
Autophagy plays an important role in the growth and survival of hepatocellular carcinoma (HCC) cells through several target proteins or signaling pathways. Glypican-3 (GPC3) is a new reliable HCC marker, which involved tumor HCC, primarily mediated by wnt/β-catenin signaling.The present study aimed to identify autophagy proliferation HepG2 GPC3/wnt/β-catenin signaling.Results demonstrated that induction nutrition starvation rapamycin treatment led downregulation GPC3 expression cells,...
Studies have revealed that resistin plays a role as an intrahepatic cytokine with proinflammatory activities. This study investigated the association between serum and fibrosis severity possible marker of in inflammatory process chronic hepatitis B.In this study, 234 subjects HBV infection were retrospectively selected, including 85 patients B (CHB), 70 HBV-related liver cirrhosis (LC-B), 79 failure (LF-B). Serum levels resistin, IL-1, IL-6, IL-17, IL-23, TNF-α, TGF-β1 assayed by ELISA....
Abstract Background Increasing evidences reveal that circular RNAs (circRNAs) play crucial functions in cancer development. However, the expression pattern and roles of circRNAs infantile hemangiomas (IH) remain unclear. Methods In this study, qRT‐PCR was performed to determine circAP2A2, miR‐382‐5p, VEGFA IH tissues cell lines. Moreover, MTT assay, colony formation, transwell Western blot analysis were conducted assess function circAP2A2 or miR‐382‐5p on proliferation, migration vitro,...
Abstract Purpose: The present study aimed to investigate the comprehensive differential expression profile of microRNAs (miRNAs) by screening for miRNA in ischemic stroke and normal samples. Methods: Differentially expressed (DEM) analysis was conducted using limma R Bioconductor package. Target genes DEMs were identified from TargetScanHuman miRTarBase databases. Functional enrichment target performed clusterProfiler miRNA-based diagnostic signature constructed via logistic regression...
The olfactory system in insects are crucial for recognition of host plants and oviposition sites. General odorant binding proteins (GOBPs) thought to be involved detecting odorants released by plants. Orthaga achatina (Lepidoptera: Pyralidae) is one the most serious pests camphor trees, Cinnamomum camphora (L.) Presl, an important urban tree species southern China. In this study, we study GOBPs O. achatina. Firstly, two full-length GOBP genes (OachGOBP1 OachGOBP2) were successfully cloned...
Abstract The general odorant‐binding proteins (GOBPs) in Lepidoptera form a distinct OBP subclass, which exclusively has two members (GOBP1 and GOBP2) single species. GOBPs are long thought to function perception of plant odorants recently sex pheromones, but the vivo evidence is rarely provided. Here, by using CRISPR/Cas9 technique, we demonstrated that GOBP1 noctuid moth Spodoptera litura involved host volatiles not female pheromone, females less important than GOBP2 perception. First,...
Ionotropic receptors (IRs) play an important role in olfaction, but little is known nondrosophila insects. Here, we report vitro and vivo functional characterization of IR75q.2 the invasive moth pest Spodoptera frugiperda. First, 13 IRs (including four coreceptor IRs) were found specifically or highly expressed adult antennae. Second, these tested for responding profiles to 59 odorants using Xenopus oocyte expression system, showing that only SfruIR75q.2 responded 8–10C fatty acids their...
The endovascular treatment of acute ischemic stroke has become a standard procedure. combination multiple neuroendovascular devices provides more possibilities for the improvement thrombectomy technique. We describe modified retrieval technique using distal intracranial catheter (DIC) semi-retrieval stentriever during retrograde involves completely unfolding stent retriever by pulling Navien and partial re-sheath retrievable forming tapered configuration pushing catheter, which results in...