A5006439235- Cancer-related molecular mechanisms research
- Glioma Diagnosis and Treatment
- Circular RNAs in diseases
- Cancer Research and Treatments
- Stress Responses and Cortisol
- Cancer, Hypoxia, and Metabolism
- Stochastic Gradient Optimization Techniques
- Domain Adaptation and Few-Shot Learning
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- Neuroendocrine regulation and behavior
- Ubiquitin and proteasome pathways
- Angiogenesis and VEGF in Cancer
- Sparse and Compressive Sensing Techniques
- Advanced Optimization Algorithms Research
- Cancer-related Molecular Pathways
- Neurological disorders and treatments
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Tryptophan and brain disorders
- Cancer-related gene regulation
- Lung Cancer Diagnosis and Treatment
- Multimodal Machine Learning Applications
- Advanced Fluorescence Microscopy Techniques
Qilu Hospital of Shandong University
2013-2025
Jinan University
2025
Southwest Petroleum University
2022-2024
Peking University First Hospital
2020-2024
Peking University
2017-2024
Sichuan University
2017-2024
West China Hospital of Sichuan University
2017-2024
Binzhou Medical University
2015-2024
Guiyang Medical University
2023-2024
National University of Defense Technology
2024
Abstract It has been hypothesized that the brain categorizes stressors and utilizes neural response pathways vary in accordance with assigned category. If this is true, should elicit patterns of neuronal activation within are category‐specific. Data from previous immediate–early gene expression mapping studies have hinted case, but interstudy differences methodology render conclusions tenuous. In present study, immunolabelling for c‐ fos was used as a marker activity elicited rat by...
Abstract Inflammatory stimuli clearly contribute to lung cancer development and progression, but the underlying pathogenic mechanisms are not fully understood. We found that proinflammatory cytokine IL-1β is dramatically elevated in serum of patients with non–small cell (NSCLC). In vitro studies showed promoted proliferation migration NSCLC cells. Mechanistically, acted through COX2–HIF1α pathway repress expression microRNA-101 (miR-101), a microRNA an established role tumor suppression....
Recent evidence suggests that dysregulation of iron regulatory factors may play essential roles in cancer pathophysiology. Six-transmembrane epithelial antigen prostate 3 (STEAP3) is a metalloreductase, which vital for cellular uptake and homeostasis. However, the clinical significance function STEAP3 development human gliomas remain unclear. Through analysis publicly available databases, we found was highly expressed malignant gliomas, especially mesenchymal glioma molecular subtype...
Convolution neural networks (CNNs) and Transformers have their own advantages both been widely used for dense prediction in multi-task learning (MTL). Most of the current studies on MTL solely rely CNN or Transformer. In this work, we present a novel model by combining merits deformable query-based Transformer prediction. Our method, named DeMT, is based simple effective encoder-decoder architecture (i.e., mixer encoder task-aware transformer decoder). First, contains two types operators:...
Transgelin-2 (TAGLN2) is a member of the calponin family actin-bundling proteins that involved in regulation cell morphology, motility, and transformation. Here, clinical significance potential function TAGLN2 malignant gliomas were investigated. Molecular data was obtained from The Cancer Genome Atlas (TCGA) database. Gene ontology pathway analysis used to predict functions TAGLN2. RNA knockdown performed using siRNA or lentiviral contructs U87MG U251 glioma lines. Cells characterized vitro...
Astaxanthin (ATX), which is the most abundant flavonoid in propolis, has previously shown neuroprotective properties against cerebral ischaemia-induced apoptosis. However, mechanisms by ATX mediates its therapeutic effects are unclear. At present, we explored underlying involved protective of via phosphoinositide 3-kinase (PI3K)/Akt/glycogen synthase kinase 3 beta (GSK3β)/nuclear factor erythroid 2-related 2 (Nrf2) signalling pathway SH-SY5Y cells. The PI3K/Akt inhibitor LY294002 and GSK3β...
Prostate cancer (PCa) is a complex disease. An ongoing accumulation of mutations results in increased genetic diversity, with the tumor acquiring distinct subclones. However, non-genetic intra-tumoral heterogeneity, cellular differentiation state and interplay between subclonal evolution transcriptional heterogeneity are poorly understood. Here, authors perform single-cell RNA sequencing from 14 untreated PCa patients. They create an extensive cell atlas patients mapped developmental states...
Tea tree oil liposomes (TTO-LPs) were prepared using thin film dispersion and orthogonal optimization. TTO solid (TTO-SLPs) then generated from TTO-LPs by spray drying, (2-Hydroxypropyl)-β-Cyclodextrin (HP-β-CD) as a drying protective agent. The physical chemical characteristics of TTO-SLPs determined, their antifungal activities against Monilinia fructicola measured. Finally, applied to peaches test effects on fruit during storage. optimal process parameters for the preparation follows:...
Abstract High‐mobility group box1 (HMGB1) induces inflammatory injury, and emerging reports suggest that it is critical for brain ischemia reperfusion. Engeletin, a natural Smilax glabra rhizomilax derivative, reported to possess anti‐inflammatory activity. Herein, we examined the mechanism of engeletin‐mediated neuroprotection in rats having transient middle cerebral artery occlusion (tMCAO) against reperfusion injury. Male SD were induced using 1.5 h tMCAO, following by 22.5 h. Engeletin...
Abstract Increased Actin-like 6A (ACTL6A) expression has been implicated in the development of diverse cancers and recently associated with Hippo signaling pathway, which is known to regulate biological properties, including proliferation, tissue regeneration, stem cell biology, as well tumorigenesis. Here we first show that ACTL6A upregulated human gliomas its glioma patient survival. promotes malignant behaviors cells vitro orthotopic xenograft model. In co-immunoprecipitation assays,...
Resistance to adjuvant radiotherapy is a major cause of treatment failure in patients with glioblastoma (GBM). Autophagy inhibitors have been shown enhance the efficacy for certain solid tumors. However, current do not penetrate blood-brain-barrier (BBB). Here, we assessed radiosensitivity effects antipsychotic drug trifluoperazine (TFP) on GBM vitro and vivo.U251 U87 cell lines as well cells from primary human biopsy (P3), were used vivo evaluate TFP treatment. Viability cytotoxicity was...
Abstract Background Osteoarthritis (OA) is a prevalent disease plaguing the elderly. Recently, chondrocyte ferroptosis has been demonstrated to promote progression of OA. Peroxisome proliferator-activated receptor-γ (PPARγ) an important factor in maintaining cartilage health. However, relationship between PPARγ and OA its mechanism completely unclear. Methods We established surgically induced knee rat model investigate Rat specimens were collected for Safranin O/Fast Green staining...
Abstract Major depressive disorder (MDD) is a severe mental associated with high rates of morbidity and mortality. Current first‐line pharmacotherapies for MDD are based on enhancement monoaminergic neurotransmission, but these antidepressants still insufficient produce significant side‐effects. Consequently, the development novel therapeutic targets desired. Engeletin, natural Smilax glabra rhizomilax derivative, compound proven efficacy in treating ischemic stroke, yet its effects...
Long noncoding RNAs (lncRNAs) have emerged as important molecules and potential new targets for human cancers. This study investigates the function of lncRNA CTBP1 antisense RNA (CTBP1-AS) in prostate cancer (PCa) explores entailed molecular mechanism. Aberrantly expressed genes potentially correlated with PCa progression were probed using integrated bioinformatics analyses. A cohort 68 patients was included, their tumor para-cancerous tissues collected. CTBP1-AS highly cells associated poor...