A5101688407- Cancer-related molecular mechanisms research
- Chronic Lymphocytic Leukemia Research
- RNA modifications and cancer
- Lymphoma Diagnosis and Treatment
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related gene regulation
- Ubiquitin and proteasome pathways
- Breast Cancer Treatment Studies
- RNA Interference and Gene Delivery
- RNA Research and Splicing
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- HER2/EGFR in Cancer Research
- Acute Myeloid Leukemia Research
- Traditional Chinese Medicine Analysis
- Medical Research and Treatments
- Advanced Battery Materials and Technologies
- Cancer-related Molecular Pathways
- Advancements in Battery Materials
- Pharmacological Effects of Natural Compounds
- Peroxisome Proliferator-Activated Receptors
- Cancer Research and Treatments
- Metabolomics and Mass Spectrometry Studies
Shandong Provincial Hospital
2016-2025
Shandong First Medical University
2020-2025
Wenzhou Medical University
2016-2025
First Affiliated Hospital of Wenzhou Medical University
2025
Air Force Medical University
2003-2025
Hainan Medical University
2022-2024
Chinese Academy of Agricultural Sciences
2024
Ministry of Agriculture and Rural Affairs
2024
Kunming Medical University
2013-2024
Anhui Medical University
2024
Abstract Purpose: The clinical relevancy of the 7-subtype classification triple-negative breast cancer (TNBC) reported by Lehmann and colleagues is unknown. We investigated TNBC heterogeneity determining pathologic complete response (pCR) rates after neoadjuvant chemotherapy, based on subtypes. Experimental Design: revalidated experiments using Affymetrix CEL files from public datasets. applied these methods to 146 patients with gene expression microarrays obtained June 2000 March 2010 at...
Purpose To determine the long-term prognosis in each phenotypic subset of breast cancer related to residual burden (RCB) after neoadjuvant chemotherapy alone, or with concurrent human epidermal growth factor receptor 2 (HER2)-targeted treatment. Methods We conducted a pathologic review measure continuous RCB index (wherein complete response has = 0; disease is categorized into three predefined classes [RCB-I, RCB-II, and RCB-III]), yp-stage disease. Patients were prospectively observed for...
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in China. N6-methyladenosine (m6A) plays an important role posttranscriptional gene regulation. METTL3 and IGF2BP2 are key genes m6A signal pathway have recently been shown to play roles cancer development progression. In our work, higher expression were found HCC tissues associated with a poor prognosis. addition, overexpression promoted proliferation vitro vivo. Mechanistically, directly recognized bound site on FEN1...
BackgroundObesity increases the risk of cancer death among postmenopausal women with estrogen receptor–positive (ER+) breast cancer, but direct evidence for mechanisms is lacking. The purpose this study to demonstrate mediating epidemiologic phenomenon.
Sargassum fusiforme fucoidan (SFF) exhibits diverse biological activities. Insulin resistance (IR) implicated in type 2 diabetes (T2D) has become an epidemic health issue worldwide. In this study, we investigated whether SFF can improve insulin sensitivity high-fat diet (HFD)-fed mice. Our present data showed that significantly reduced fasting blood glucose and IR index along with improved tolerance. Impaired phosphorylation of Akt was also restored by SFF. Furthermore, decreased the levels...
Abstract Electrochemical properties of lithium–sulfur (Li–S) batteries are mainly hindered by both the insulating nature elemental sulfur (i.e., molecular S 8 ) and shuttling effect or sluggish redox kinetics lithium polysulfide intermediates (Li 2 n , 3 ≤ 8). In this paper, a three‐dimensional mesoporous reduced graphene oxide‐based nanocomposite, with embedding metallic Co nanoparticles doping N (Co/NrGO), its simply ground mixture powdered at mass ratio 1:6 (Co/NrGO/S) prepared used as...
When compared to other malignancies, the tumor microenvironment (TME) of primary and castration-resistant prostate cancer (CRPC) is relatively devoid immune infiltrates. While androgen deprivation therapy (ADT) induces a complex infiltrate in localized cancer, composition TME metastatic castration-sensitive (mCSPC), effects ADT treatments this context are poorly understood. Here, we perform comprehensive single-cell RNA sequencing (scRNA-seq) profiling sites from patients participating phase...
5-Aminolevulinic acid (5-ALA) has recently attracted attention for its potential applications in the fields of medicine and agriculture. In this study, Corynebacterium glutamicum was firstly engineered 5-ALA production via C4 pathway. HemA encoding 5-aminolevulinic synthase from Rhodobacter sphaeroides codon optimized expressed C. ATCC13032, resulting accumulation 5-ALA. Deletion all known genes responsible formation acetate lactate further enhanced Overexpression ppc gene phoenolpyruvate...
Mitochondrial transcription factor A (TFAM) is essential for the replication, and maintenance of mitochondrial DNA (mtDNA). The role TFAM in non-small cell lung cancer (NSCLC) remains largely unknown. Herein, we report that downregulation NSCLC cells resulted cycle arrest at G1 phase significantly blocked growth migration through activation reactive oxygen species (ROS)-induced c-Jun amino-terminal kinase(JNK)/p38 MAPK signaling decreased cellular bioenergetics. We further found led to...
Highlights•Fluvastatin effectively prevents lung adenocarcinoma bone metastasis in a nude mouse model.•Fluvastatin-induced anti-bone metastatic property was largely dependent on its ability to induce autophagy.•Fluvastatin-induced autophagy and activity are mediated by p53.Statins, inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, most frequently prescribed cholesterol-lowering agent with minimal side effects. In this study, we present novel function statins...
Abstract Osteosarcoma (OS) is the most common pediatric malignant bone tumor, and occurrence of pulmonary metastasis generally causes a rapid fatal outcome. Here we aimed to provide clues for exploring mechanism tumorigenesis OS by comprehensive analysis microRNA (miRNA), long non-coding RNA (lncRNA), mRNA expression in primary metastasis. In this study, deep sequencing with samples from ( n = 3), metastatic normal controls 3) was conducted differentially expressed miRNAs (DEmiRNAs), lncRNAs...
Abstract Background Hippo-Yes-associated protein (YAP) signaling is a key regulator of organ size and tumorigenesis, yet the underlying molecular mechanism still poorly understood. At present, significance Hippo-YAP pathway in diffuse large B-cell lymphoma (DLBCL) ill-defined. Methods The expression YAP DLBCL was determined public database clinical specimens. effects knockdown, CRISPR/Cas9-mediated deletion, inhibitor treatment on cell proliferation cycle were evaluated both vitro vivo. RNA...
Abstract Background Sirtuin 6 (Sirt6) is a highly conserved ADP-ribosylase and NAD+ dependent deacylase, involved in broad cellular processes. This molecule possesses contradictory roles carcinogenesis, as it has been documented to both suppressing augmenting tumor growth. project aimed explore the expression functions of Sirt6 diffuse large B-cell lymphoma (DLBCL), especially with regards regulatory role OSS_128167, novel small molecular inhibitor targeting Sirt6. Methods...