A5100411150- Gut microbiota and health
- RNA modifications and cancer
- COVID-19 Impact on Reproduction
- Liver Disease Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- HIV/AIDS Research and Interventions
- Pregnancy and Medication Impact
- Urinary Tract Infections Management
- Advanced biosensing and bioanalysis techniques
- Clostridium difficile and Clostridium perfringens research
- Diet and metabolism studies
- Hepatitis C virus research
- Infant Nutrition and Health
- Barrier Structure and Function Studies
- Cancer Risks and Factors
- Cancer Genomics and Diagnostics
- Helicobacter pylori-related gastroenterology studies
- Pelvic floor disorders treatments
- Pediatric health and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Advanced Biosensing Techniques and Applications
- Biomedical Text Mining and Ontologies
- Pressure Ulcer Prevention and Management
- Diabetic Foot Ulcer Assessment and Management
- Forensic and Genetic Research
Chengdu Medical College
2025
Southern Medical University
2022-2025
Foshan Second People's Hospital
2025
Chongqing Medical University
2015-2024
Mengchao Hepatobiliary Hospital
2024
Fujian Medical University
2024
Army Medical University
2019-2024
Washington University in St. Louis
2024
Hospital of Hebei Province
2024
Southern Medical University Shenzhen Hospital
2020-2024
Abstract Background Lower respiratory tract (LRT) microbiome has been reported to associate with pulmonary diseases. Unregulated inflammation is an underlying cause of variable lung The may play important role in the smoking-induced inflammatory What’s more, function be more for understanding how microbes interact host. Our study aims explore effects smoking on lower microbiome, association between variation and whether exposure changes microbime. Methods Forty male mice were randomly...
Sargassum fusiforme fucoidan (SFF) exhibits diverse biological activities. Insulin resistance (IR) implicated in type 2 diabetes (T2D) has become an epidemic health issue worldwide. In this study, we investigated whether SFF can improve insulin sensitivity high-fat diet (HFD)-fed mice. Our present data showed that significantly reduced fasting blood glucose and IR index along with improved tolerance. Impaired phosphorylation of Akt was also restored by SFF. Furthermore, decreased the levels...
Based on the New Diagnosis and Treatment Scheme for Novel Coronavirus Infected Pneumonia (Trial Edition 5), combined with our current clinical treatment experience, we recently proposed a revision of first edition "Guidance maternal fetal management during pneumonia epidemics novel coronavirus infection in Wuhan Tongji Hospital". This article focused issues greatest concern pregnant women including severe acute respiratory syndrome 2 (SARS-CoV-2) diagnostic criteria, inspection precautions,...
We investigated the protective effect of Rehmannia glutinosa oligosaccharides (RGO) on lipopolysaccharide (LPS)-induced intestinal inflammation and barrier injury among mice.RGO is prepared from fresh rehmannia by water extraction, active carbon decolorization, ion exchange resin impurity removal, macroporous adsorption purification, decompression drying. LPS could establish model for in mice. Three different doses RGO were administered three consecutive weeks. Then weight, feces, health...
Recent studies break with traditional opinion that the lower respiratory tract is sterile, and increasingly focus on lung microbiome disease. Smoking, as an important etiology of inflammatory disease, was considered a factor influencing variations in our study, we aimed to study effect smoking inflammation microbial diversity community. Forty male mice were selected randomly divided into non-smoking group. Mice group exposed smoke smog for 2 h/day 90 days. Blood tissues obtained after...
The early development of the gut microbiome is governed by multiple factors and has significantly long-term effects on later-in-life health. To minimize inter-individual variations in environment, we determined developmental trajectories 28 healthy neonates during their stay at a postpartum center. Stool samples were collected three time points: first-pass meconium within 24 h life, 7 days age. Illumina sequencing V3-V4 region 16S rRNA was used to investigate microbiota profiles. We found...
Proteinuria is one of the common manifestations patients with preeclampsia (PE), but whether severity proteinuria related to pregnancy outcome remains controversial. The present study aimed determine relationship between 24-h and adverse outcomes in preeclampsia.The retrospective included 329 pregnant women Chongqing, China. Patients were divided into PE group non-PE group. was stratified three subgroups based on level proteinuria. Correlation analysis used analyze correlation biochemical...
There are different degrees of erectile dysfunction in men after radical prostatectomy, and it takes a long time for their sexual satisfaction to improve. Before the recovery function, patient's relationship experience may change, which affect family stability. Therefore, present study aimed comprehensively understand patients prostatectomy. The was qualitative using phenomenological method. Purposive sampling used select 16 with prostate cancer who were followed up prostatectomy Chengdu,...
The aim of this study was to evaluate the association dynamic neutrophil-to-lymphocyte ratio (NLR) with 3-month functional outcomes in patients sICH. We retrospectively identified 213 consecutive sICH hospitalized First Affiliated Hospital Zhengzhou University from January 2017 May 2018. Patients were divided into independence (FI) or unfavorable prognosis (UP) groups based on outcomes. Admission leukocyte counts within 24 hours symptom onset obtained, and recorded fraction, which numerator...
By comparing the detection rate and type of targeted gene mutations in non-small cell lung cancer (NSCLC) between amplification refractory mutation system PCR (ARMS-PCR) next-generation sequencing (NGS), characteristics application advantages are explained, providing a basis for clinicians to effectively select corresponding methods.The cases genes were selected from First Affiliated Hospital Chongqing Medical University January 2016 October 2020. A sample 4467 was selected, they diagnosed...
An emerging number of studies have recently revealed the correlation between burn injuries and psychological disorders. Gut microbiota inflammatory factors may play a vital role in this process. Nevertheless, there are few conducted to disclose potential mechanism gut depression injuries. In study, we constructed model C57BL/6 mice, which showed that symptom became more severe with mice lasted longer. Meanwhile, significant differences composition among before after burn. Then, tested brain...
Abstract Aim To develop a conceptual framework for proactive health behavior among middle‐aged and older adult females with urinary incontinence. Design Qualitative grounded theory study. Background There is growing body of research emphasizing the pivotal significance behavior. Proactive can empower patients to actively manage their illnesses facilitate disease recovery. Clearly defining patients' relevant beliefs assumptions regarding effectively promote adoption. However, there currently...
Gut microbiome development during early life has significant long-term effects on health later in life. The first-pass meconium is not sterile, and it important to know the initial founder of subsequent gut microbiome. However, there limited data microbiota profile healthy neonates. To determine profile, we analyzed 39 samples from neonates using 16S rRNA sequencing. Our results showed a similar composition samples. Pseudomonas was most abundant genus evenness microbial communities extremely...
Important forensic evidence traced from crime scenes, such as fecal materials, can help in the investigation of criminal cases. Intestines are largest microbial pool human body whose community is considered to be "second fingerprint". The present study explored potential for characteristics gut microbes medicine. Fecal microbiota profiles healthy individuals three representative Han populations (Guangzhou, Shantou and Meizhou) Guangdong Province, China were evaluated using High-throughput...
Background and AimsHepatitis B virus (HBV) reactivation is commonly observed in individuals with chronic HBV infection undergoing antineoplastic drug therapy. Paclitaxel (PTX) treatment has been identified as a potential trigger for reactivation. This study aimed to uncover the mechanisms of PTX-induced vitro vivo, which may inform new strategies antiviral treatment.
This study investigated the association between serum albumin concentration and 12-weeks mortality of HIV/AIDS with late diagnosis in China. retrospective cohort included, 1079 inpatients January 2018 December 2021. Disease progression was estimated based on rate. Cox proportional hazards regression models were used to evaluate relationship levels disease progression. The effects via Kaplan-Meier curves. risk decreased by 7% every 1 g/L increase after adjustment ([HR] = 0.93, 95% CI:...
ADVERTISEMENT RETURN TO ISSUEPREVReportNEXTApplication of Solution-Phase Parallel Synthesis to Preparation Trisubstituted 1,2,4-TriazolesScott W. Martin, Jeffrey L. Romine, Ling Chen, Gail Mattson, Ildiko A. Antal-Zimanyi, and Graham S. PoindexterView Author Information Department Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Parkway, Wallingford, Connecticut 06492 Cite this: J. Comb. Chem. 2004, 6, 1, 35–37Publication Date (Web):November 19, 2003Publication History...