A5059789770- Molecular Biology Techniques and Applications
- Forensic and Genetic Research
- RNA modifications and cancer
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Genetic diversity and population structure
- Plant Pathogens and Fungal Diseases
- Nuclear Receptors and Signaling
- Ferroptosis and cancer prognosis
- Cancer-related gene regulation
- Endoplasmic Reticulum Stress and Disease
- Fungal Plant Pathogen Control
- Plant Disease Resistance and Genetics
- Phytochemical and Pharmacological Studies
- Thyroid Disorders and Treatments
- Metabolomics and Mass Spectrometry Studies
- Healthcare and Venom Research
- Neurological Complications and Syndromes
- Epigenetics and DNA Methylation
- Plant tissue culture and regeneration
- Diabetes Treatment and Management
- COVID-19 Clinical Research Studies
- Colorectal Cancer Screening and Detection
- Genetic Syndromes and Imprinting
- Yeasts and Rust Fungi Studies
Hubei University of Medicine
2024
First Affiliated Hospital of Guangdong Pharmaceutical University
2018-2024
Nanjing Medical University
2014-2022
Qingdao Agricultural University
2019-2022
Guangzhou University of Chinese Medicine
2020
Nanjing Normal University
2014
Colorectal cancer (CRC) is one of the leading causes tumor-related death worldwide, and its main cause distant metastasis. Methyltransferase-like 14(METTL14), a major RNA N6-adenosine methyltransferase, involved in tumor progression via regulating function. The goal study to uncover biological function molecular mechanism METTL14 CRC.Quantitative real-time PCR (qRT-PCR), western blot immunohistochemical (IHC) assays were employed detect SOX4 CRC cell lines tissues. functions demonstrated...
Abstract Background A severe form of pneumonia, named coronavirus disease 2019 (COVID-19) by the World Health Organization is widespread on whole world. The acute respiratory syndrome 2 (SARS-CoV-2) was proved to be main agent COVID-19. In present study, we conducted an in depth analysis SARS-COV-2 nucleocapsid identify potential targets that may allow identification therapeutic targets. Methods N protein subcellular localization and physicochemical property analyzed PSORT II Prediction...
Long non‐coding RNAs (lncRNAs) have been recently recognized as a major class of regulators in mammalian systems. 91H, novel long noncoding antisense transcripts located on the position H19/IGF2 locus has suggested to play potential tumor‐suppressor role tumor development. However, little study proved mechanism esophageal squamous cell carcinoma (ESCC). We carried out this explore lncRNA 91H regulation H19 imprinting control regions (ICR) and IGF2 expression association between ESCC...
Abstract During the process of cold crucible two-step treatment high-level liquid waste, volatilization radionuclides Tc, Cs, Sr, etc. will occur. Because similarity between physicochemical properties Re and we choose instead Tc to avoid radioactive exposure in calcination stage volatility experiment. exists as ReO4 − environment, while alkali earth metal cation is added, then finished at high temperature. The perrhenic acid combines with form perrhenate. There are two volatile forms...
With people's changing life style and dietary habits, the prevalence of type 2 diabetes mellitus (T2DM) has become much more serious than ever before. T2DM is a polygenic metabolic disorder, resulting from interaction genetic various environmental factors. Among all related genes, transcription factor 7 like (TCF7L2) gene one most relevant risk-related genes for T2DM. However, role TCF7L2 in pathogenesis not yet been interpreted thoroughly. Based on experimental studies recent years, this...
According to historical records, ethnic Hui in China obtained substantial genetic components from western Eurasian populations during their Islamization. However, some scholars believed that the ancestry of people were native Chinese populations. In this context, formation is due simple cultural diffusion rather than demic diffusion. study, we examined forensic and population application 30 InDel loci Ningxia Autonomous Region, Northwest China. Genotype analysis 129 unrelated individuals...
Fusarium graminearum is the predominant causal agent of cereal head blight disease (FHB) worldwide. The application chemical fungicides such as azole antifungals still primary method for FHB control. However, to date, our knowledge transcriptional regulation in resistance F. quite limited. In this study, we identified and functionally characterized a Zn(II)2-Cys6 transcription factor FgAtrR graminearum. We constructed deletion mutant found that resulted faster radial growth with serious...
Important forensic evidence traced from crime scenes, such as fecal materials, can help in the investigation of criminal cases. Intestines are largest microbial pool human body whose community is considered to be "second fingerprint". The present study explored potential for characteristics gut microbes medicine. Fecal microbiota profiles healthy individuals three representative Han populations (Guangzhou, Shantou and Meizhou) Guangdong Province, China were evaluated using High-throughput...
Abstract Here we studied the genetic polymorphism and evolutionary differentiation of Guangdong Liannan Yao population based on 15 autosomal STR loci 19 Y chromosomal loci. The blood card DNA 302 unrelated individuals from Autonomous County was directly amplified using an Expressmarker 16 + 19Y kit genotyped a 3500XL Genetic Analyzer. For loci, CPD value over 0.999 999 999, while CPE 0.9999. comparison revealed closer relationship between She ethnic than other reported Chinese populations....
Objective This study aimed to examine the levels of solute carrier family seven number 11 (SLC7A11) and glutathione peroxidase 4 (GPX4) in serum patients with acute ischaemic stroke (AIS) their relationship disease severity. Methods A total 148 AIS together healthy controls (HCs) were enrolled. The expression SLC7A11 GPX4 detected immediately as early possible. Radiographic severity was by Alberta Stroke Program Early CT Score (ASPECTS). Disease evaluated using modified Rankin Scale (mRS)....
Abstract Single-nucleotide polymorphisms (SNPs) in the transcription factor 7-like 2 (TCF7L2) gene have been identified to be associated with susceptibility type diabetes mellitus (T2DM) various populations worldwide, but results Chinese are conflicting, and no data available about Liannan Yao population. Therefore, this study aimed investigate association of TCF7L2 (rs12255372, rs7903146, rs7901695, rs11196205, rs7895340) T2DM population living rural areas Autonomous County. This was a...
Abstract Background Genetic polymorphism and haplotype distribution characteristics analysis of mitochondrial DNA in Chinese Guangdong Liannan Yao group was conducted this study, to provide genetic basis for tracing the origin historical migration people. Results 46 mutation sites were found, among which single nucleotide transition most commonly observed variant (86.17%). Multiple (sub)haplogroups detected ethnic group, haplogroup D common (29.80%), least C Y(0.48% respectively)....
The emergence of 5-Fluorouracil (5-FU) resistance is the barrier to effective clinical outcomes for CRC patients. Autophagy was found be involved in protecting tumor cells from 5-FU. However, specific role autophagy-related genes 5-FU remains unclear. In this study, HSPB8 among 34 differentially expressed ARGs identified hub resistant which down-regulated samples when compared with normal but up-regulated relatively higher lymphatic invasion, later stages and poor prognosis CRC. Mechanistic...