A5039755997- Lipid metabolism and biosynthesis
- Plant biochemistry and biosynthesis
- Microbial Metabolic Engineering and Bioproduction
- Chemistry and Chemical Engineering
- Research in Cotton Cultivation
- vaccines and immunoinformatics approaches
- HIV/AIDS drug development and treatment
- Phytochemistry and Bioactive Compounds
- interferon and immune responses
- Click Chemistry and Applications
- SARS-CoV-2 and COVID-19 Research
- Porphyrin and Phthalocyanine Chemistry
- ATP Synthase and ATPases Research
- Cancer Treatment and Pharmacology
- Radical Photochemical Reactions
- HIV Research and Treatment
- Mitochondrial Function and Pathology
- DNA and Nucleic Acid Chemistry
- Tuberculosis Research and Epidemiology
- Marine Sponges and Natural Products
- Neurogenesis and neuroplasticity mechanisms
- Porphyrin Metabolism and Disorders
- Fluorine in Organic Chemistry
Dalian Medical University
2024
First Affiliated Hospital of Dalian Medical University
2024
Nanjing Medical University
2021
Experimental Station
1969
DuPont (United States)
1969
Abstract Background A severe form of pneumonia, named coronavirus disease 2019 (COVID-19) by the World Health Organization is widespread on whole world. The acute respiratory syndrome 2 (SARS-CoV-2) was proved to be main agent COVID-19. In present study, we conducted an in depth analysis SARS-COV-2 nucleocapsid identify potential targets that may allow identification therapeutic targets. Methods N protein subcellular localization and physicochemical property analyzed PSORT II Prediction...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT2,3-Iminosqualene, a potent inhibitor of the enzymic cyclization 2,3-oxidosqualene to sterolsElias J. Corey, Paul R. Ortiz de Montellano, Kang. Lin, and Peter D. G. DeanCite this: Am. Chem. Soc. 1967, 89, 11, 2797–2798Publication Date (Print):May 1, 1967Publication History Published online1 May 2002Published inissue 1 1967https://pubs.acs.org/doi/10.1021/ja00987a089https://doi.org/10.1021/ja00987a089research-articleACS PublicationsRequest reuse...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTtrans-2-Cycloheptenone1Philip E. Eaton and Kang LinCite this: J. Am. Chem. Soc. 1965, 87, 9, 2052–2054Publication Date (Print):May 1, 1965Publication History Published online1 May 2002Published inissue 1 1965https://pubs.acs.org/doi/10.1021/ja01087a038https://doi.org/10.1021/ja01087a038research-articleACS PublicationsRequest reuse permissionsArticle Views287Altmetric-Citations62LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTtrans-2-CyclooctenonePhilip E. Eaton and Kang. LinCite this: J. Am. Chem. Soc. 1964, 86, 10, 2087–2088Publication Date (Print):May 1, 1964Publication History Published online1 May 2002Published inissue 1 1964https://pubs.acs.org/doi/10.1021/ja01064a049https://doi.org/10.1021/ja01064a049research-articleACS PublicationsRequest reuse permissionsArticle Views313Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of...
The transformation of 2,3-oxidosqualene to lanosterol is catalyzed by a microsomal enzyme (cyclase) which can be obtained in soluble and partially purified form treatment liver microsomes with deoxycholate as previously shown. catalytic physical properties the are determined ionic strength. In 0.4 M KCl cyclase exists largely dissociated, enzymatically active form. Solutions low strength (0.1 or less) cause aggregation loss activity. anionic detergent essential for activity, but effective...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThree-Dimensional Structure-Activity Analysis of a Series Porphyrin Derivatives with Anti-HIV-1 Activity Targeted to the V3 Loop gp120 Envelope Glycoprotein Human Immunodeficiency Virus Type 1Asim Kumar Debnath, Shibo Jiang, Nathan Strick, Kang Lin, Paul Haberfield, and A. Robert NeurathCite this: J. Med. Chem. 1994, 37, 8, 1099–1108Publication Date (Print):April 1, 1994Publication History Published online1 May 2002Published inissue 1 April...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSeparation of the cyclization and rearrangement processes lanosterol biosynthesis. Enzymic conversion 20,21-dehydro-2,3-oxidosqualene to a dehydroprotosterolElias J. Corey, Kang Lin, Hisashi YamamotoCite this: Am. Chem. Soc. 1969, 91, 8, 2132–2134Publication Date (Print):April 1, 1969Publication History Published online1 May 2002Published inissue 1 April 1969https://doi.org/10.1021/ja01036a059RIGHTS & PERMISSIONSArticle...
ADVERTISEMENT RETURN TO ISSUEPREVArticleAdditions and Corrections - Three-Dimensional Structure-Activity Analysis of a Series Porphyrin Derivatives with Anti-HIV-1 Activity Targeted to the V3 Loop gp120 Envelope Glycoprotein Human Immunodeficiency Virus Type 1.Asim Debnath, Shibo Jiang, Nathan Strick, Kang Lin, Paul Haberfield, A. Robert NeurathCite this: J. Med. Chem. 1994, 37, 12, 1898Publication Date (Print):June 1, 1994Publication History Published online29 September 2004Published...