A5101939613- Platelet Disorders and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Pulmonary Hypertension Research and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Ophthalmology and Visual Health Research
- Phytochemistry and Bioactive Compounds
- Cancer, Hypoxia, and Metabolism
- Blood groups and transfusion
- Erythropoietin and Anemia Treatment
- Autoimmune Bullous Skin Diseases
- Ginseng Biological Effects and Applications
- Dermatology and Skin Diseases
- Inflammatory Biomarkers in Disease Prognosis
- Long-Term Effects of COVID-19
- Immune cells in cancer
- COVID-19 and healthcare impacts
- Psoriasis: Treatment and Pathogenesis
- Iron Metabolism and Disorders
- Natural product bioactivities and synthesis
- Pharmacological Effects of Natural Compounds
- Chemokine receptors and signaling
- COVID-19 Clinical Research Studies
- Blood Coagulation and Thrombosis Mechanisms
Wuhan University of Science and Technology
2022-2025
Chengdu Medical College
2024
Huazhong University of Science and Technology
2018-2022
Xiangnan University
2021
Zhejiang Gongshang University
2018
Introduction Traditional Miao and Dai Chinese medicines have used nicotine-rich leaf tobacco to treat traumatic injuries by promoting hemostasis. While nicotine is known enhance platelet aggregation, its effects on other functions underlying mechanisms remain unclear. Methods Results This study aimed thoroughly investigate nicotine’s human platelets pharmacological mechanisms, using thromboelastography assess impact function during coagulation. the functional of elucidate mechanisms. The...
Tumor-associated thrombosis is the second leading risk factor for cancer patient death, and platelets activity abnormal in patients. Discovering mechanism of platelet activation providing effective targets therapy are urgently needed. Cancer cell- derived IgG has been reported to regulate development tumors. However, studies on functions cell-derived quite limited. Here we investigated potential role activation. We detected expression CD62P by flow cytometry analyzed function aggregation ATP...
Metabolic reprogramming is a hallmark of pulmonary arterial hypertension. Platelet activation has been implicated in hypertension (PAH), whereas the role platelet pathogenesis PAH remains unclear.First, we explored function semaxanib' inhibitor VEGF receptor (SU5416)/hypoxia mice and monocrotaline-injected rats model. Then investigated smooth muscle cell aerobic glycolysis after being treated with supernatant. TGF (transforming growth factor)-βRI, pyruvate kinase 2, other antagonists were...
The mechanisms and biological functions of migrating platelets in cancer remain largely unknown. Here, we analyzed platelet infiltration hepatocellular carcinoma. We detected extravasation both mouse human HCC tissues. CX3CL1 directly induced migration, hypoxia enhanced migration by upregulating expression. Knocking down cells reduced vitro , as well tissue an orthotopic model. Components the CX3CR1/Syk/PI3K pathway were essential for CX3CL1‐induced migration. Migrating cell apoptosis...
Sanguinarine, a benzophenanthridine alkaloid, has been described to have an antiplatelet activity. However, its antithrombotic effect and the mechanism of platelet inhibition not thoroughly explored. The current study found that sanguinarine had inhibitory on thrombus formation. This was quite evident both in flow-chamber assays as well murine model FeCl3-induced carotid artery thrombosis. Further investigations also revealed inhibited collagen-induced human aggregation granule release. At...
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This research aimed to study the changes in platelet function and their underlying mechanisms iron deficiency anemia. Initially, we evaluated an IDA mice model. Due inability accurately reduce intracellular Fe2+ concentrations, investigated impact of on by introducing varying concentrations Fe2+. To probe mechanism, simultaneously examined dynamics calcium cytosol, integrin αIIbβ3 activation Fe2+-treated platelets. Ferroptosis inhibitors Lip-1 Fer-1 were applied determine whether ferroptosis...
Objective To investigate the prevalence and clinical features of nail involvement in patients with psoriasis vulgaris, to explore its relationship manifestations, laboratory findings metabolic syndrome. Methods Clinical data were collected from 315 outpatients vulgaris who visited Department Dermatology, Peking Union Medical College Hospital between September 1, 2011 April 2014, retrospectively analyzed. The as well syndrome assessed. Results Of 156 (49.5%) had involvement. most...
Objective To analyze the incidence and factors of college students asthenopia. Methods In June 2018, a questionnaire survey was conducted on in university Hangzhou, 622 questionnaires were retrieved for statistical analysis. Results There retrieved, 581 cases (93.40%) had asthenopia syndrome. Among them, 499 (80.22%) systemic symptoms. There 5 aspects to its pathogenic ophthalmopathy, diseases around eye, disease, environmental science application...