A5054036240- Sulfur Compounds in Biology
- Adenosine and Purinergic Signaling
- Escherichia coli research studies
- Genomics, phytochemicals, and oxidative stress
- Antibiotic Resistance in Bacteria
- Vibrio bacteria research studies
- Viral gastroenteritis research and epidemiology
- Endoplasmic Reticulum Stress and Disease
- Heme Oxygenase-1 and Carbon Monoxide
- Inflammasome and immune disorders
- Cytokine Signaling Pathways and Interactions
- Porphyrin and Phthalocyanine Chemistry
- Cancer-related molecular mechanisms research
- Eicosanoids and Hypertension Pharmacology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Acute Ischemic Stroke Management
- Redox biology and oxidative stress
- Antibiotics Pharmacokinetics and Efficacy
- Air Quality and Health Impacts
- Immune cells in cancer
- RNA Research and Splicing
- Immune Cell Function and Interaction
- Nanoplatforms for cancer theranostics
- Estrogen and related hormone effects
- Microplastics and Plastic Pollution
Nankai University
2022-2025
Akita University
2025
Wuhan University of Science and Technology
2024
Kumamoto University
2015-2024
Sichuan University
2021-2023
West China Hospital of Sichuan University
2023
Northwest A&F University
2023
Quzhou University
2023
Zhejiang University
2023
Zhengzhou University
2023
Abstract Diagnosis and treatment at an early stage may improve survival of non‐small‐cell lung cancer (NSCLC). Previous studies have found that long noncoding RNA growth arrest‐specific transcript 5 (GAS5) is essential to progression. However, the expression diagnostic value GAS5 in exosomes (Exo‐GAS5) remain unclear. One hundred four participants were enrolled, including subjects with NSCLC ( n = 64) healthy 40). The total Exosome Isolation Kit was applied isolate from serum. Total...
Fusobacterium nucleatum (F. nucleatum) is a gut microbe implicated in gastrointestinal tumorigenesis. Predicting the chemotherapeutic response critical to developing personalised therapeutic strategies for oesophageal cancer patients. The present study investigated relationship between F. and resistance squamous cell carcinoma (ESCC).We examined chemotherapy 120 ESCC resected specimens 30 pre-treatment biopsy specimens. In vitro studies using lines co-culture assays further uncovered...
The NLRP3 inflammasome is a multiprotein complex responsible for the maturation of precursor forms interleukin (IL)-1β and IL-18 into active proinflammatory cytokines. Increasing evidence suggests that modulation redox homeostasis contributes to activation inflammasome. However, specific mechanistic details remain unclear. We demonstrate here ATP exposure evoked sharp decrease in glutathione (GSH) levels macrophages, which led activation. detected an increase GSH culture supernatants was...
Abstract Innate immunity plays an important role in host defense against microbial infections. It also participates activation of acquired through cytokine production and antigen presentation. Pattern recognition receptors such as Toll-like nucleotide oligomerization domain-like sense invading pathogens associated tissue injury, after which inflammatory mediators pro-inflammatory cytokines nitric oxide are induced. Supersulfides molecular species possessing catenated sulfur atoms persulfide...
Polysulfides have received increased interest in redox biology due to their role as the precursors of H2S and persulfides. However, compounds that are suitable for biological investigations limited cysteine- glutathione-derived polysulfides. In this work, we report preparation evaluation a novel polysulfide derived from thioglucose, which represents first carbohydrate-based polysulfide. This compound, thioglucose tetrasulfide (TGS4), showed excellent stability water solubility. persulfide...
Schizophrenia (SCZ) is a debilitating psychiatric disorder marked by alterations in cognition and social behavior, resulting profound impacts on individuals society. Although sex-dependent disparities the epidemiology of SCZ are well established, biological molecular basis these remains poorly understood. Investigating cell type-specific transcriptomic profiles critical for identifying regulatory components underlying dysregulation SCZ, which could serve as targets sex-specific therapeutic...
Sirtuins are nicotinamide adenine dinucleotide (NAD+)-dependent deacylases that remove acyl groups from lysine residues on target proteins, releasing nicotinamide. SIRT7 is associated with aging and a number of age-related diseases, but the enzymatic properties largely unknown. In present study, we investigated biochemical activity by performing series in vitro kinetic studies presence different substrates. The binding affinity for NAD+ was dependent substrate, showed preference...
Hydrogen sulfide (H2S) formed during sulfur metabolism in bacteria has been implicated the development of intrinsic resistance to antibacterial agents. Despite conversion H2S hydropersulfides greatly enhancing biochemical properties such as antioxidant activity, effects on antibiotic have remained unknown. In this work, we investigated alone or together with cystine form cysteine hydropersulfide (CysSSH) activities By using disc diffusion test, found that CysSSH treatment effectively...
Ovarian cancer stem cells (OCSC), endowed with tumor-initiating and self-renewal capacity, would account not only for the tumor growth, peritoneal metastasis, relapse, but also acquisition of chemotherapy resistance. Nevertheless, figuring out their phenotypical functional traits has proven quite challenging, mainly because heterogeneity ovarian cancer. A deeper understanding OCSC mechanisms will shed light on development disease. Therefore, we aim to explore it design innovative treatment...
Despite the development of many functional fabrics, they are unable to meet practical needs due their monolithic functions and low durability. Therefore, a multifunctional waterborne polyurethane nanodroplet containing disulfide bonds (WSPU) was synthesized using simple environmentally friendly approach. The WSPU coating endowed fabrics with variety properties, including exceptional hydrophobicity, antibacterial self-healing at room temperature, directional transport, etc. functionalized...