A5068838933- Pancreatic and Hepatic Oncology Research
- Epigenetics and DNA Methylation
- Esophageal Cancer Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Genomics and Diagnostics
- Colorectal Cancer Screening and Detection
- Neuroendocrine Tumor Research Advances
- Radiomics and Machine Learning in Medical Imaging
- Gastric Cancer Management and Outcomes
- Cancer Immunotherapy and Biomarkers
- Pancreatitis Pathology and Treatment
- Gallbladder and Bile Duct Disorders
- Colorectal Cancer Treatments and Studies
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Ferroptosis and cancer prognosis
- Lung Cancer Research Studies
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Metastasis and carcinoma case studies
- Pediatric Hepatobiliary Diseases and Treatments
- Genetic and Kidney Cyst Diseases
- Cancer Mechanisms and Therapy
Kumamoto University
2016-2024
Sunagawa City Medical Center
2020-2024
Baylor University Medical Center
2018-2022
Baylor Medical Center at Garland
2019-2022
Baylor Scott & White Health
2019
City of Hope
2019
Beckman Research Institute
2019
Saiseikai Kumamoto Hospital
2009-2015
Niigata University
2002-2003
Nihon University
2002
Fusobacterium nucleatum (F. nucleatum) is a component of the human microbiome that primarily inhabits oral cavity. It causes periodontal disease and has also been implicated in development cancers. Although there are several reports relationship between F. clinical outcome cancers, its prognostic significance esophageal cancer remains unclear.We quantified DNA 325 resected specimens by qPCR. Significant pathways nucleatum-positive tissues were identified Kyoto Encyclopedia Genes Genomes...
Abstract Purpose: Emerging evidence indicates that gut microbiome plays a crucial role in the cancer pathogenesis. Although Fusobacterium nucleatum (F. nucleatum) is associated with poor prognosis multiple cancers, its clinical significance predicting response to chemotherapy patients esophageal squamous cell carcinoma (ESCC) remains unclear. Experimental Design: The F. levels were quantified by qPCR assays tumor tissues from 551 ESCC two independent cohorts, including 101 who received...
Inflammation and immune characteristics of the tumour microenvironment have therapeutic significance. The aim this study was to investigate clinical impact on disease progression in human extrahepatic cholangiocarcinoma (ECC). A total 114 consecutive ECC patients with curative resection between 2000 2014 were enrolled. Tumour infiltrating CD66b+ neutrophils (TANs; associated neutrophils), CD163+ M2 macrophages (TAMs; macrophages), CD8+ T cells, FOXP3+ regulatory cells (Tregs) assayed by...
Fusobacterium nucleatum (F. nucleatum) is a gut microbe implicated in gastrointestinal tumorigenesis. Predicting the chemotherapeutic response critical to developing personalised therapeutic strategies for oesophageal cancer patients. The present study investigated relationship between F. and resistance squamous cell carcinoma (ESCC).We examined chemotherapy 120 ESCC resected specimens 30 pre-treatment biopsy specimens. In vitro studies using lines co-culture assays further uncovered...
DNA methylation alterations have emerged as front-runners in cell-free (cfDNA) biomarker development. However, much effort to date has focused on single cancers. In this context, gastrointestinal (GI) cancers constitute the second leading cause of cancer-related deaths worldwide; yet there is no blood-based assay for early detection and population screening GI cancers.Herein, we performed a genome-wide analysis multiple develop pan-GI diagnostic assay. By analyzing data from 1,781 tumor...
Background/Aim: As indicators of systemic inflammatory response, the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte (PLR) predict prognoses for various cancers. This study investigated their prognostic significance in extrahepatic cholangiocarcinoma (ECC). Patients Methods: We analyzed 120 patients who underwent surgery ECC between 2000 2014. calculated preoperative NLR PLR evaluated correlations with patients9 clinicopathological features prognosis. Results: Although high...
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with dismal survival rates. Tumor microenvironment (TME), comprising of immune cells and cancer-associated fibroblasts, plays key role in driving poor prognosis resistance to chemotherapy. Herein, we aimed identify TME-associated, risk-stratification gene biomarker signature PDAC.The initial discovery was performed The Cancer Genome Atlas (TCGA, n = 163) transcriptomic data. This followed by independent validation the International...
Abstract The annual postoperative disease‐free survival for colorectal liver metastases can be easily estimated by weighting six preoperative clinical parameters (Beppu score). We identified three recurrence‐risk stratification groups: the low (≤6 points), moderate (7–10 and high‐risk (≥11 points). For low‐, moderate‐, patients, hepatectomy alone, with adjuvant chemotherapy, chemotherapy are recommended, respectively. Beppu score enables decision on necessity timing of perioperative chemotherapy.
// Takayoshi Kaida 1 , Hidetoshi Nitta Yuki Kitano Kensuke Yamamura Kota Arima Daisuke Izumi Takaaki Higashi Junji Kurashige Katsunori Imai Hiromitsu Hayashi Masaaki Iwatsuki Takatsugu Ishimoto Hashimoto Yoichi Yamashita Akira Chikamoto Takahisa Imanura 2 Takatoshi Ishiko Toru Beppu Hideo Baba Department of Gastroenterological Surgery, Graduate School Life Sciences, Kumamoto University, Kumamoto, Japan Molecular Pathology, Correspondence to: Baba, email: hdobaba@kumamoto-u.ac.jp Keywords:...
Postoperative recurrence beyond the Milan criteria is a poor prognostic factor for patients with hepatocellular carcinoma (HCC) treated various therapies. We investigated most useful inflammation-based score predicting after initial liver resection.From January 2007 to December 2012, 271 consecutive HCC who underwent curative resection were enrolled. Patients divided according pattern: criteria; and within criteria, or no recurrence. The classified into two groups, low platelet-to-lymphocyte...
Metastatic lesion of the pancreas originated from other organs is uncommon. The aim this report was to evaluate outcome surgery in patients with isolated metastases pancreas. Nine underwent pancreatic resection for metastatic malignant disease 2000 2015 at Department Gastroenterological Surgery Kumamoto University Hospital. primary renal cell carcinoma 7 cases, colon cancer 1 and melanoma 1. median interval initial operation 138 months. Operative procedure distal pancreatectomy 6...
An ectopic hepatocellular carcinoma (EHCC) arises from the liver which is defined as a hepatic organ or tissue not connected to surrounding tissues. EHCC rare disease and it difficult diagnose preoperatively. Furthermore, clinical features are fully elucidated.A retroperitoneal tumor (6 cm) was located at dorsal side of pancreas head on abdominal ultrasonography in an 81-year old woman positive for hepatitis C virus antibody. Contrast enhanced-computed tomography...
Background and Aims Tumor recurrence is frequent even in intrahepatic cholangiocarcinoma (ICC), improved strategies are needed to identify patients at highest risk for such recurrence. We performed genome‐wide expression profile analyses discover validate a gene signature associated with ICC. Approach Results For biomarker discovery, we analyzed transcriptomic profiling ICC tumors from two public data sets: The Cancer Genome Atlas (n = 27) GSE107943 28). identified an eight‐gene panel (...