A5101680908- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Cancer, Hypoxia, and Metabolism
- Esophageal and GI Pathology
- Peroxisome Proliferator-Activated Receptors
- Inflammatory Biomarkers in Disease Prognosis
- Colorectal Cancer Surgical Treatments
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Treatments and Studies
- Gastrointestinal Tumor Research and Treatment
- Nutrition and Health in Aging
- Cancer Immunotherapy and Biomarkers
- Cancer, Lipids, and Metabolism
- Lung Cancer Diagnosis and Treatment
- MicroRNA in disease regulation
- Metastasis and carcinoma case studies
- Cancer Research and Treatments
- Eicosanoids and Hypertension Pharmacology
- Chemokine receptors and signaling
- Genetic factors in colorectal cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Metabolism, Diabetes, and Cancer
- Colorectal and Anal Carcinomas
Kumamoto University
2014-2023
Kumamoto City Hospital
2018-2021
Tokyo-Kita Medical Center
2020
Kumamoto Medical Center
2015-2019
Daiichi-Sankyo (Japan)
2013
Kyushu University
2013
Saiseikai Kumamoto Hospital
2009-2011
Fusobacterium nucleatum (F. nucleatum) is a component of the human microbiome that primarily inhabits oral cavity. It causes periodontal disease and has also been implicated in development cancers. Although there are several reports relationship between F. clinical outcome cancers, its prognostic significance esophageal cancer remains unclear.We quantified DNA 325 resected specimens by qPCR. Significant pathways nucleatum-positive tissues were identified Kyoto Encyclopedia Genes Genomes...
Cancer-associated fibroblasts (CAFs) are reportedly involved in invasion and metastasis several types of cancer, including gastric cancer (GC), through the stimulation CXCL12/CXCR4 signaling. However, mechanisms underlying these tumor-promoting effects not well understood, which limits potential to develop therapeutic targets against CAF-mediated CXCL12 expression was analyzed resected GC tissues from 110 patients by immunohistochemistry (IHC). We established primary cultures normal (NFs)...
CD44 is frequently overexpressed in a wide variety of epithelial malignancies including gastrointestinal cancer and causes resistance to currently available treatments. MicroRNAs (miRNAs) are non-coding RNAs that regulate molecular pathways by targeting various genes. The aim this study was investigate the regulation expression miRNAs develop new targets cancer. We performed miRNA screening six human cell lines identified three candidate could Among these, we focused on miR-328 examined its...
Abstract Glucose transporter 1 ( GLUT 1) expression is a prognostic marker for esophageal squamous cell carcinoma ESCC ). Recent work on and development of specific inhibitors supports the feasibility inhibition as treatment various cancers. The anti–proliferative effects 1‐specific small interfering RNA (si ) inhibitor were evaluated in lines. Expression pro–proliferative signaling effector molecules was examined by western blotting quantitative RT ‐ PCR . pretreatment clinical biopsy...
Bmi1 is overexpressed in a variety of human cancers including gastrointestinal cancer. The high expression level protein associated with poor prognosis cancer patients. On the other hand, tumor-associated macrophages (TAMs) contribute to tumor growth, invasion, and metastasis by producing various mediators microenvironment. aim this study was investigate TAM-mediated regulation relationship between TAMs analyzed immunohistochemistry quantitative real-time PCR (qRT-PCR), results showed...
Abstract RNF43 mutations are frequently detected in colorectal cancer cells and lead to a loss of function the ubiquitin E3 ligase. Here, we investigated clinical significance large Japanese cohort role at various stages development progression. Mutation analysis gene locus with pyrosequencing technology hotspot one (0.88%) 113 polyp cases 30 (6.45%) 465 cases. Moreover, patients harbouring mutated experienced higher recurrence rate than those non‐mutated . In addition, growth wild‐type cell...
Systemic inflammation may influence the response to systemic chemotherapy or prognosis in patients with various cancers. The Naples prognostic score, based on inflammatory and nutritional statuses, is a useful marker undergoing surgery for colorectal cancer; however, its significance metastatic cancer remains unclear.We aimed evaluate of factor receiving first-line compare accuracy neutrophil:lymphocyte ratio, platelet:lymphocyte immune-inflammatory index.This was retrospective study...
The transcription factor PPAR-γ plays various roles in lipid metabolism, inflammation, cellular differentiation, and apoptosis. agonists used to treat diabetes may have utility cancer treatment. Efatutazone is a novel later generation agonist that selectively activates target genes has antiproliferative effects range of malignancies. In this study, we investigated status esophageal squamous cell carcinoma (ESCC) the efatutazone. was expressed heterogeneously ESCC, which it exhibited an...