A5060338958- Bone and Joint Diseases
- Bone health and treatments
- Obstructive Sleep Apnea Research
- Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
- Dysphagia Assessment and Management
- Bone Tumor Diagnosis and Treatments
- Colorectal Cancer Surgical Treatments
- Neuroscience of respiration and sleep
- Inflammatory Biomarkers in Disease Prognosis
- Oral and Maxillofacial Pathology
- Colorectal Cancer Treatments and Studies
- Cancer, Lipids, and Metabolism
- Reconstructive Surgery and Microvascular Techniques
- Oral health in cancer treatment
- Esophageal and GI Pathology
- Colorectal Cancer Screening and Detection
- Salivary Gland Tumors Diagnosis and Treatment
- Hearing Loss and Rehabilitation
- Colorectal and Anal Carcinomas
- Cleft Lip and Palate Research
- Nutrition and Health in Aging
- Nosocomial Infections in ICU
- Tracheal and airway disorders
- Ear and Head Tumors
University Medical Center
2024
Osaka Prefectural Medical Center
2024
Kansai Medical University
2021-2024
Columbia University Irving Medical Center
2024
The Ark
2024
Nippon Medical School
2024
Kumamoto University
1994-2023
Tokushima University
2017-2022
Kumamoto Medical Center
2022
Nagasaki University
2012-2021
Methods for preventing medication-related osteonecrosis of the jaw (MRONJ) in cancer patients who have received high-dose bisphosphonate (BP) or denosumab (Dmab) not yet been established. Tooth extraction after starting medication has believed to be a major risk factor MRONJ, and therefore this procedure tends avoided. This study investigated factors with special reference correlation between tooth development MRONJ. One hundred thirty-five were administrated BP Dmab enrolled study....
Abstract Fusobacterium nucleatum has been detected in 8%‐13% of human colorectal cancer, and shown to inhibit immune responses against primary tumors animal models. Thus, we hypothesized that the presence F . might be associated with reduced T cell density cancer liver metastases (CRLM). We quantified DNA 181 CRLM specimens using quantitative PCR assay. The densities CD8 + cells, CD33 cells (marker for myeloid‐derived suppressor [MDSCs]), CD163 tumor‐associated macrophages [TAMs]) tissue...
The aim of this retrospective study was to assess the efficacy and safety cetuximab therapy for patients with locally advanced (LA) recurrent/metastatic (R/M) oral squamous cell carcinoma (OSCC), a specific focus on distant metastases (DMs). Data from 21 unresectable LA R/M OSCC treated in our department between December, 2012 July, 2015 were reviewed. endpoint time-to-progression assessments made tumor response rate, progression-free survival (PFS), overall (OS) safety. rate 57.1%, complete...
Systemic inflammation may influence the response to systemic chemotherapy or prognosis in patients with various cancers. The Naples prognostic score, based on inflammatory and nutritional statuses, is a useful marker undergoing surgery for colorectal cancer; however, its significance metastatic cancer remains unclear.We aimed evaluate of factor receiving first-line compare accuracy neutrophil:lymphocyte ratio, platelet:lymphocyte immune-inflammatory index.This was retrospective study...
We retrospectively evaluated the impact of postoperative complications on long-term outcomes after curative resection for colorectal cancer (CRC), using propensity-score analysis (PSA).We reviewed data from 673 consecutive patients with stage I to III CRC, who underwent resections between 2005 and 2017. Patients were divided into complication group (Clavien-Dindo [CD] grade ≥ 3) control (others). performed PSA obtain unbiased estimates effects oncological background each outcome.We matched...
The aim of the present study was to identify most useful markers for predicting recurrence keratocystic odontogenic tumors (KCOTs). A total 65 tumor samples from 63 patients diagnosed with typical parakeratinized cysts and KCOTs between 1992 2014 were retrospectively studied. Clinical histopathological data treatment modality reviewed. In addition, expression profiles Ki-67, cluster differentiation (CD)34 podoplanin assessed using immunohistochemistry. association these factors rate KCOT...
Abstract Purpose In 2-dimensional lateral cephalometric radiographs, patients with severe obstructive sleep apnea (OSA) exhibit a more crowded oropharynx in comparison non-OSA. We tested the hypothesis that machine learning, an application of artificial intelligence (AI), could be used to detect OSA based on images. Methods A deep convolutional neural network was developed ( n = 1258; 90%) and 131; 10%) using data from 1389 (100%) radiographs obtained individuals diagnosed 867; hypopnea...
The Controlling Nutritional Status (CONUT) score is a useful nutritional evaluation, that calculated from serum albumin, total cholesterol concentrations, and lymphocyte count. This study aimed to investigate the association between CONUT prognosis in patients with metastatic colorectal cancer (mCRC).The was retrospectively 211 mCRC receiving first-line chemotherapy. were divided into three groups: low-group (0-1), intermediate-group (2-4), high-group (5-). associations of...
Abstract Background The advanced lung cancer inflammation index (ALI), which comprehensively evaluates the patient body composition and inflammation/nutritional status, is reportedly associated with outcome in cancer. However, clinical significance colorectal (CRC) patients after curative resection remains unclear. Methods A total of 813 CRC between April 2005 June 2019 a single institution were retrospectively enrolled. association preoperative ALI (calculated as follows: mass × albumin...
The species difference in the turnover rates of cholesteryl ester (CE) cycle macrophage foam cells (MFC) was examined mice and rats. MFC were induced by acetyl-LDL pulsed with [3H]oleate, followed a chase [14C]oleate. replacement initial amount [3H]oleate [14C]oleate within 24 hours 63% mouse MFC, whereas it 33% rat MFC. corresponding rabbit < 10%. In addition, HDL removed 41% CE mass from but only 22% HDL-induced reduction enhanced 40% inhibitor for acyl-coenzyme A:cholesterol...
Total body water (TBW) fraction, which accounts for 60% of weight, is an important indicator composition, and the extracellular to TBW ratio (ECW/TBW) reportedly useful in predicting clinical outcomes patients with organ disorders. We aimed clarify impact preoperative ECW/TBW status on survival cancer patients.
The predictors of restenosis after endovascular therapy (EVT) with paclitaxel drug-coated balloons (DCBs) have not been clearly established. present study aimed to investigate the association post-procedural dissection, as evaluated using intravascular ultrasound (IVUS), risk following femoropopliteal EVT DCBs.
Tongue pressure plays an important role in swallowing function. The purpose of this study is to investigate whether decreased tongue associated with dysphagia and the development pneumonia elderly requiring long-term care.Tongue measurement videoendoscopic (VE) examination were performed 60 hospitalized people (33 males 27 females, average age 84.3 years) relationship clinical course. Factors related was analyzed by Fisher's exact test one-way ANOVA, followed multivariate logistic...
Introduction Medication-related osteonecrosis of the jaw (MRONJ) develops from odontogenic infection. However, there are also some cases MRONJ developing sites with no teeth, root canal lesions, or periodontal disease. This study aimed to retrospectively review radiographic images and examine differences in characteristics between suspected be related dental infection (odontogenic MRONJ) that occurred without involvement unknown cause (non-odontogenic MRONJ). Materials methods One hundred...
Medication-related osteonecrosis of the jaw (ONJ) is caused by antiresorptive (bisphosphonates and denosumab) antiangiogenic agents, with first report denosumab-related ONJ emerging in 2010. To date, although certain case reports on have been published, those a single application drug are scarce. In addition, only one described histopathological features this condition, not completely; sequestrum resected conservative surgery was evaluated. Although treatment recommended, effectiveness...
This study is aimed at clarifying the relationship between visit-to-visit variability of glycated hemoglobin (HbA1c) and risk diabetic kidney disease (DKD) to identifying most useful index HbA1c. clinic-based retrospective longitudinal included 699 Japanese type 2 diabetes mellitus patients. Visit-to-visit HbA1c was calculated as internal standard deviation (HbA1c-SD), coefficient variation (HbA1c-CV), change score (HbA1c-HVS), area under curve (HbA1c-AUC) with 3-year serial measurement...