A5085126930- Tendon Structure and Treatment
- Pain Mechanisms and Treatments
- Orthopedic Surgery and Rehabilitation
- Shoulder Injury and Treatment
- Cancer-related molecular mechanisms research
- Lung Cancer Research Studies
- Corneal surgery and disorders
- Knee injuries and reconstruction techniques
- Lung Cancer Treatments and Mutations
- Intraocular Surgery and Lenses
- RNA and protein synthesis mechanisms
- Machine Learning in Bioinformatics
- Genomics and Phylogenetic Studies
- Radiomics and Machine Learning in Medical Imaging
- Brain Metastases and Treatment
- Circular RNAs in diseases
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Retinal Diseases and Treatments
- Cancer Treatment and Pharmacology
- Glaucoma and retinal disorders
- Cannabis and Cannabinoid Research
- Pharmacological Effects of Natural Compounds
Nanjing Drum Tower Hospital
2012-2025
Nanjing Medical University
2016-2025
Shanghai Jiao Tong University
2024-2025
Nanjing Jiangning Hospital
2025
Yangtze Optical Electronic (China)
2025
Peking University
2020-2025
Peking University Third Hospital
2025
Jiangxi Agricultural University
2020-2024
People's Liberation Army 401 Hospital
2024
Chinese People's Liberation Army
2024
Motion between a tendon graft and bone tunnel may impair incorporation lead to widening.Healing of in is inhibited by graft-tunnel motion.Controlled laboratory study.Anterior cruciate ligament reconstruction was performed 5 cadaveric rabbit limbs, 3-dimensional motion measured using micro-computed tomography. The authors then bilateral anterior 15 rabbits used histomorphometry compare tendon-to-bone healing the aperture, midtunnel, exit posterior aspects tunnel.Graft-tunnel greatest at...
Background: Macrophages accumulate following tendon-to-bone repair and may contribute to the formation of a scar-tissue interface rather than reformation normal insertion site. We hypothesized that macrophage depletion lead improved site regeneration, in form "scar-less" healing reactive formation. Methods: One hundred ninety-two Sprague-Dawley rats underwent anterior cruciate ligament reconstruction with use flexor tendon autograft were divided into control group (ninety-six rats) liposomal...
Rotator cuff tendon heals by formation of an interposed zone fibrovascular scar tissue. Recent studies demonstrate that transforming growth factor-beta 3 (TGF-β(3)) is associated with tissue regeneration and "scarless" healing, in contrast to scar-mediated healing occurs TGF-β(1).Delivery TGF-β(3) injectable calcium-phosphate matrix the tendon-bone interface after rotator repair will result increased attachment strength secondary improved bone collagen organization reduced...
SETDB1 is a histone H3K9 methyltransferase that has critical role in early development. It located within melanoma susceptibility locus and facilitates formation. However, the mechanism by which regulates tumorigenesis remains unknown. Here we report molecular interplay between well-known hotspot gain-of-function (GOF) TP53 R249S mutation. We show hepatocellular carcinoma (HCC) overexpressed with moderate copy number gain, GOF mutations including associate this overexpression. Inactivation...
Healing of an anterior cruciate ligament graft in a bone tunnel occurs by formation fibrous scar tissue, which is weaker than the normal fibrocartilaginous insertion.We hypothesized that magnesium-based adhesive would improve tendon-to-bone healing rabbit reconstruction model.Controlled laboratory study.Thirty-five New Zealand White rabbits underwent bilateral reconstructions with semitendinosus autografts. A total 12.5 g was placed intraosseous around one limb, while tunnels contralateral...
The purpose of this study was to determine the effect diabetic phenotype on mechanical properties native patellar tendon and its enthesis. Diabetes induced via intraperitoneal injection streptozotocin in Lewis rats. Control (n = 18) animals 20) were killed at 12 19 days for analysis. Statistical comparisons performed using Student's t-tests a two-tailed Fisher test with significance set p < 0.05. Pre- post-injection glucose tolerance tests demonstrated significant impairment glycemic control...
Abstract Motivation Many forms of variations exist in the human genome including single nucleotide polymorphism, small insert/deletion (DEL) (indel) and structural variation (SV). Somatically acquired SV may regulate expression tumor-related genes result cell proliferation uncontrolled growth, eventually inducing tumor formation. Virus integration with host sequence is a type that causes related gene instability normal cells to transform into cells. Cancer SVs viral sites must be discovered...
Abstract Background Many long non-coding RNAs (lncRNAs) have key roles in different human biologic processes and are closely linked to numerous diseases, according cumulative evidence. Predicting potential lncRNA-disease associations can help detect disease biomarkers perform analysis prevention. Establishing effective computational methods for association prediction is critical. Results In this paper, we propose a novel model named MAGCNSE predict underlying associations. We first obtain...
Cumulative studies have shown that many long non-coding RNAs (lncRNAs) are crucial in a number of diseases. Predicting potential lncRNA-disease associations (LDAs) can facilitate disease prevention, diagnosis and treatment. Therefore, it is vital to develop practical computational methods for LDA prediction. In this study, we propose novel predictor named capsule network (CapsNet)-LDA CapsNet-LDA first uses stacked autoencoder acquiring the informative low-dimensional representations pairs...
Abstract Background DNA N4-methylcytosine is part of the restrictive modification system, which works by regulating some biological processes, for example, initiation replication, mismatch repair and inactivation transposon. However, using experimental methods to detect 4mC sites time-consuming expensive. Besides, considering huge differences in number samples among different species, it challenging achieve a robust multi-species site prediction performance. Hence, great significance develop...
Healing of a tendon graft in bone tunnel depends on ingrowth into the interface between and bone. Excessive osteoclastic activity may contribute to resorption, widening, impaired healing. We hypothesized that inhibition by osteoprotegerin (OPG) would increase formation around anterior cruciate ligament reconstruction rabbit model, while increased due application receptor activator nuclear factor-kappa B ligand (RANKL) impair ingrowth.Sixty skeletally mature, male New Zealand White rabbits...
Computational pathology, utilizing whole slide images (WSIs) for pathological diagnosis, has advanced the development of intelligent healthcare. However, scarcity annotated data and histological differences hinder general application existing methods. Extensive histopathological robustness self-supervised models in small-scale demonstrate promising prospects developing foundation pathology models. Here we show BEPH (BEiT-based model Pre-training on Histopathological image), a that leverages...
<title>Abstract</title> <bold>Background:</bold> The use of machine learning (ML) techniques, particularly XGBoost and logistic regression, to predict sarcopenia among postsurgical gastric cancer patients has gained significant attention in recent research. Sarcopenia, characterized by the progressive loss skeletal muscle mass strength, is a serious concern these due its association with poor postoperative outcomes, including increased morbidity mortality. In this study, was used establish...
The use of machine learning (ML) techniques, particularly XGBoost and logistic regression, to predict sarcopenia among postsurgical gastric cancer patients has gained significant attention in recent research. Sarcopenia, characterized by the progressive loss skeletal muscle mass strength, is a serious concern these due its association with poor postoperative outcomes, including increased morbidity mortality. In this study, was used establish risk prediction model for undergoing gastrectomy...
Abstract Successful rotator cuff tendon repair depends on secure tendon‐to‐bone healing. Recombinant human parathyroid hormone (rhPTH) has been shown in multiple studies to accelerate bone Recent have also that rhPTH is chondrogenic by increasing chondrocyte recruitment and differentiation. We hypothesized would improve healing a rat model. One hundred fourteen Sprague Dawley rats underwent division of the supraspinatus tendon. Fifty seven received daily subcutaneous injections 10 µg/kg...
Minor head trauma is a frequent cause of emergency department visits, early identification and prediction mild traumatic brain injury (mTBI) patients with abnormal lesions are vital for minimizing unnecessary computed tomography (CT) scans, reducing radiation exposure, ensuring timely effective treatment care. This study aims to develop validate an interpretable machine learning (ML) model using routine laboratory data guiding clinical decisions on CT scan use in mTBI patients. We conducted...