A5100699466- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Extracellular vesicles in disease
- Autophagy in Disease and Therapy
- Nanoplatforms for cancer theranostics
- Immune cells in cancer
- RNA Interference and Gene Delivery
- Renal cell carcinoma treatment
- Cancer Mechanisms and Therapy
- Cancer-related gene regulation
- RNA Research and Splicing
- Ubiquitin and proteasome pathways
- Cancer, Lipids, and Metabolism
- Viral-associated cancers and disorders
- Cancer Genomics and Diagnostics
- Inflammasome and immune disorders
- Glioma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Lung Cancer Research Studies
Xiangya Hospital Central South University
2016-2025
Central South University
2016-2025
Zhejiang University
2018-2025
University of South China
2025
China Medical University
2021-2025
Shandong Academy of Sciences
2023-2025
Qilu University of Technology
2023-2025
Shandong University
2025
First Affiliated Hospital Zhejiang University
2020-2024
University of Huddersfield
2019-2024
Ferroptosis is an iron-dependent cell death process that plays important regulatory roles in the occurrence and development of cancers, including hepatocellular carcinoma (HCC). Moreover, molecular events surrounding aberrantly expressed long non-coding RNAs (lncRNAs) drive HCC initiation progression have attracted increasing attention. However, research on ferroptosis-related lncRNA prognostic signature patients with still lacking. In this study, association between differentially lncRNAs...
Abstract The cGAS-STING signaling pathway has emerged as a critical mediator of innate immune responses, playing crucial role in improving antitumor immunity through effector responses. Targeting the holds promise for overcoming immunosuppressive tumor microenvironments (TME) and promoting effective elimination. However, systemic administration current STING agonists faces challenges related to low bioavailability potential adverse effects, thus limiting their clinical applicability....
The gasdermin (GSDM) superfamily has been demonstrated to consist of several important molecules that modulate multifunctional signal processes, such as cell pyroptosis. In this research, the roles GSDM on occurrence and prognosis lung adenocarcinoma (LUAD) were evaluated using integrative bioinformatic analyses in vitro methods. Here, data from platforms revealed GSDMC is significantly upregulated LUAD tissues lines. Real‑time fluorescence quantitative PCR (qPCR) was obviously...
Background: LncRNAs have been shown to play essential roles in cancer therapeutic response. However, the detailed mechanism of lncRNAs temozolomide (TMZ) resistance glioblastoma (GBM) remain be elucidated. Methods: To elucidate maintaining TMZ resistance, we constructed two TMZ-resistant GBM cell lines (T98G-R/U118-R). from four public datasets were reanalyzed, and candidate lncRNA ADAMTS9-AS2 was evaluated TMZ-treated patients vitro lines. Results: Reanalysis expression profiles identified...
Lipoic acid synthetase (LIAS) has been demonstrated to play a crucial role in the progression of cancer. Exploring underlying mechanisms and biological functions LIAS could have potential therapeutic guidance for cancer treatment. Our study explored expression levels prognostic values pan-cancer through several bioinformatics platforms, including TIMER2.0, Gene Expression Profiling Interactive Analysis, version 2 (GEPIA2.0), Human Protein Atlas (HPA). We found that high was related good...
Recent studies have discovered that tiny particles of microplastics (MPs) at the nano-scale level can enter body organisms from environment, potentially causing metabolic ailments. However, further investigation is required to understand alterations in immune microenvironment associated with non-alcoholic fatty liver disease (NAFLD) occurrence following exposure MPs. Experiments were performed using mice, which given a normal chow or high-fat diet (NCD HFD, respectively) plus free drinking...
Abstract Temozolomide (TMZ) represents a standard-of-care chemotherapeutic agent in glioblastoma (GBM). However, the development of drug resistance constitutes significant hurdle treatment malignant glioma. Although specific innovative approaches, such as immunotherapy, have shown favorable clinical outcomes, inherent invasiveness most gliomas continues to make them challenging treat. Consequently, there is an urgent need identify effective therapeutic targets for overcome chemoresistance...
Resistance to temozolomide (TMZ), the standard chemotherapy agent for glioblastoma (GBM), poses a major clinical challenge GBM prognosis. Understanding mechanisms of TMZ resistance can help identify novel drug targets and more effective therapies. Recent studies suggest that bioenergetic alterations cancer cells play important roles in resistance. In our study, altered metabolism was observed using metabolic PCR array. We found stearoyl-coenzyme A desaturase 1 (SCD1), key rate-limiting...
Glucose-6-phosphate dehydrogenase (G6PD) is a rate-limiting enzyme of the pentose phosphate pathway. Multiple studies have previously revealed that elevated G6PD levels promote cancer progression in numerous tumor types; however, underlying mechanism remains unclear. In present study, it was demonstrated high expression poor prognostic factor bladder cancer, and increase with increasing stage. Patients had worse survival rates compared those lower resected tumors. vitro experiments knockdown...