A5100384226- Advanced Chemical Physics Studies
- Spectroscopy and Quantum Chemical Studies
- Spectroscopy and Laser Applications
- Quantum, superfluid, helium dynamics
- Atmospheric Ozone and Climate
- Polymer crystallization and properties
- Polymer Nanocomposites and Properties
- Conducting polymers and applications
- Electrospun Nanofibers in Biomedical Applications
- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Textile materials and evaluations
- Tribology and Wear Analysis
- Glass properties and applications
- Synthesis and properties of polymers
- 3D Printing in Biomedical Research
- RNA Interference and Gene Delivery
- Molecular Spectroscopy and Structure
- Advanced Sensor and Energy Harvesting Materials
- biodegradable polymer synthesis and properties
- Advanced Numerical Analysis Techniques
- Natural Fiber Reinforced Composites
- Reservoir Engineering and Simulation Methods
- Bladder and Urothelial Cancer Treatments
- Chemotherapy-induced organ toxicity mitigation
Huanggang Normal University
2019-2025
First Hospital of Qinhuangdao
2023-2024
First Affiliated Hospital Zhejiang University
2010-2023
Hebei Medical University
2023
Institute of Electrical and Electronics Engineers
2023
Engineering Systems (United States)
2023
University of Memphis
2023
Antea Group (France)
2023
Harbin University of Science and Technology
2023
Shanghai University
2013-2022
State-of-the-art quantum simulations on a full-dimensional ab initio potential energy surface are used to characterize the properties of water hexamer. The relative populations different isomers determined over wide range temperatures. While prism isomer is identified as global minimum-energy structure, simulations, which explicitly include zero-point and thermal motion, predict that both cage present at low temperature down almost 0 K. This largely consistent with available experimental...
We employ recent flexible ab initio potential energy and dipole surfaces [Y. Wang, X. Huang, B. C. Shepler, J. Braams, M. Bowman, Chem. Phys. 134, 094509 (2011)] to the calculation of IR spectra intramolecular modes water clusters. use a quantum approach that begins with partitioned normal-mode analysis perturbed monomers, then obtains solutions corresponding Schrödinger equations for fully coupled each monomer. For clusters, these are two stretches bend. This is tested against benchmark...
A tumor-on-a-chip platform with integration of decellularized liver matrix offers better biomimicry tumor microenvironment and enhanced toxicity testing.
Cancer chemotherapy drug cisplatin is known for its nephrotoxicity. The aim of this study to investigate whether Epigallocatechin 3-Gallate (EGCG) can reduce mediated side effect in kidney and understand mechanism protection against tissue injury. We used a well-established 3-day induced nephrotoxicity mice model where EGCG were administered. major active compound Green Tea have strong anti-oxidant anti-inflammatory properties. protected renal dysfunction as measured by serum creatinine...
Metastasis is one of the most important factors that lead to poor prognosis in cancer patients, and effective suppression growth primary cells a metastatic site paramount averting progression. However, there lack biomimetic three-dimensional (3D) vitro models can closely mimic continuous an organ-specific extracellular microenvironment (ECM) for assessing therapeutic strategies. Methods: In this tumor progression model, kidney (Caki-1) hepatocytes (i.e., HepLL cells) were co-cultured at...
Indium phosphide (InP) based quantum dots (QDs) have been known as an ideal alternative to heavy metals including QDs light emitters, such cadmium selenium (CdSe) QDs, and show great promise in the next-generation solid-state lighting displays. However, electroluminescence performance of green InP is still inferior their red counterparts, due higher density surface defects wider particle size distribution. Here, a quasi-shell-growth strategy for growth highly luminescent InP/ZnSe/ZnS...
We report a chemically accurate global potential energy surface for the HOCO system based on high-level ab initio calculations at ~35,000 points. The is shown to reproduce important stationary points and minimum paths. Quasi-classical trajectory indicated good agreement with experimental data.
Glucose-6-phosphate dehydrogenase (G6PD) is a rate-limiting enzyme of the pentose phosphate pathway. Multiple studies have previously revealed that elevated G6PD levels promote cancer progression in numerous tumor types; however, underlying mechanism remains unclear. In present study, it was demonstrated high expression poor prognostic factor bladder cancer, and increase with increasing stage. Patients had worse survival rates compared those lower resected tumors. vitro experiments knockdown...
Indium phosphide (InP) quantum dots (QDs) have demonstrated great potential for light-emitting diode (LED) application because of their excellent optical properties and nontoxicity. However, the over performance InP QDs still lags behind that CdSe QDs, one main reasons is Zn traps in lattices can be formed through cation exchange ZnSe shell growth process. Herein, we realized highly luminescent InP/ZnSe/ZnS by constructing Se-rich shielding layers on surfaces cores, which simultaneously...
The calculation and characterization of the IR spectrum liquid water have remained a challenge for theory. In this paper, we address using combination ab initio approaches, namely, quantum treatment WHBB potential energy surface refined dipole moment surface. is based on embedded local monomer method, in which three intramolecular modes each H2O are fully coupled also singly to six intermolecular modes. new consists previous spectroscopically accurate 1-body newly fitted intrinsic 2-body...
Abstract Extracellular vesicles (EVs) derived from immune cells have shown great anti-cancer therapeutic potential. However, inefficiency in EV generation has considerably impeded the development of EV-based basic research and clinical translation. Here, we developed a seesaw-motion bioreactor (SMB) system by leveraging mechanical stimuli such as shear stress turbulence for generating EVs with high quality quantity natural killer (NK) cells. Compared to production traditional static culture...
A sensor for non-enzymatic hydrogen peroxide (H2O2) was developed based on silicon quantum dots (SiQDs). The fluorescent SiQDs were synthesized using a one-pot hydrothermal method. made water-soluble...
We present extensions to the local-monomer (LMon) Model, a general quantum method describe coupled intramolecular vibrational modes of molecular cluster consisting set monomers [Y. Wang and J. M. Bowman, Chem. Phys. 134, 154510 (2011)]10.1063/1.3579995, incorporate monomer-monomer coupling. A central aspect LMon model is local normal-mode analysis, done for each monomer, perturbed by all other mononers. Monomer-monomer coupling described several approaches based on these analyses. Two are...
ConspectusWater is one of the most pervasive molecules on earth and other planetary bodies; it molecule that searched for as presumptive precursor to extraterrestrial life. It also paradigm substance illustrating ubiquitous hydrogen bonding (H-bonding) in gas phase, liquids, crystals, amorphous solids. Moreover, H-bonding with between different utmost importance chemistry biology. no wonder, then, nearly a century theoreticians experimentalists have tried understand all aspects its influence...
We report a joint experimental-theoretical study of the predissociation dynamics water trimer following excitation hydrogen bonded OH-stretch fundamental. The bond dissociation energy (D0) for (H2O)3 → H2O + (H2O)2 channel is determined from fitting speed distributions selected rovibrational states monomer fragment using velocity map imaging. experimental value, D0 = 2650 ± 150 cm(-1), in good agreement with previously theoretical 2726 30 obtained an ab initio full-dimensional potential...
We present a theory of mode-specific tunneling that makes use the general path along imaginary-frequency normal mode saddle point, Qim, and associated relaxed potential, V(Qim) [Y. Wang J. M. Bowman, Chem. Phys. 129, 121103 (2008)]. The novel aspect is projection modes minimum onto Qim determination turning points on V(Qim). From projection, change in upon excitation can be calculated. If zero, no enhancement predicted. In case vibrationally adiabatic (VA) could apply. However, if large then...
Despite recent advances in cancer treatment, developing better therapeutic reagents remains an essential task for oncologists. To accurately characterize drug efficacy, 3D cell culture holds great promise as opposed to conventional 2D monolayer culture. Due the advantages of manipulation high-throughput, various microfluidic platforms have been developed screening with models. However, dissemination technology is overall slow, and one missing part fast low-cost assay readout. In this work,...