A5101697117- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Glioma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Acute Myeloid Leukemia Research
- Ferroptosis and cancer prognosis
- ATP Synthase and ATPases Research
- Genetic and rare skin diseases.
- Epigenetics and DNA Methylation
- Gout, Hyperuricemia, Uric Acid
- Cancer, Lipids, and Metabolism
- Chromium effects and bioremediation
- Beetle Biology and Toxicology Studies
- Transplantation: Methods and Outcomes
- Lung Cancer Research Studies
- Selenium in Biological Systems
- DNA Repair Mechanisms
- Lymphoma Diagnosis and Treatment
- Tumors and Oncological Cases
- Wireless Body Area Networks
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Polyomavirus and related diseases
- Microwave Imaging and Scattering Analysis
- Cancer-related Molecular Pathways
- Wastewater Treatment and Nitrogen Removal
Sun Yat-sen University Cancer Center
2021-2024
Sun Yat-sen University
2021-2024
Central South University
2011-2022
Xiangya Hospital Central South University
2016-2022
Second Xiangya Hospital of Central South University
2013-2015
University of Electronic Science and Technology of China
2014
Nasopharyngeal carcinoma (NPC) has a particularly high prevalence in southern China, southeastern Asia and northern Africa. Radiation resistance remains serious obstacle to successful treatment NPC. This study aimed explore the metabolic feature of radiation-resistant NPC cells identify new molecular-targeted agents improve therapeutic effects radiotherapy Methods: Radiation-responsive were used as model system vitro vivo. Metabolomics approach was illustrate global changes. 13C isotopomer...
Abstract Mutations in isocitrate dehydrogenases (IDH) are oncogenic events due to the generation of metabolite 2-hydroxyglutarate. However, role wild-type IDH cancer development remains elusive. Here we show that IDH2 is highly expressed triple negative breast (TNBC) cells and promotes their proliferation vitro tumor growth vivo. Genetic silencing or pharmacological inhibition wt-IDH2 causes a significant increase α-ketoglutarate (α-KG), indicating suppression reductive tricarboxylic acid...
Hotspot mutations of isocitrate dehydrogenase 1 and 2 (IDH1/2) have been studied in several cancers.However, the function wild-type IDH2 lung cancer mechanism its contribution to growth cells remain unknown.Here, we explored role promoting cancer.Methods: Information regarding genomic clinical application focusing on was examined databases more than 1,000 tumor samples.IDH2 expression assessed by immunohistochemistry tissues from patients.The biological functions were evaluated using...
Abstract Background Isocitrate dehydrogenase-2 (IDH2) is a mitochondrial enzyme that catalyzes the metabolic conversion between isocitrate and alpha-ketoglutarate (α-KG) in TCA cycle. IDH2 mutation an oncogenic event acute myeloid leukemia (AML) due to generation of 2-hydroxyglutarate. However, role wild-type AML remains unknown, despite patients with it suffer worse clinical outcome than those harboring mutant type. Methods expression cell lines patient samples was evaluated by RT-qPCR,...
Epstein–Barr virus (EBV) is a well-recognized oncogenic that can induce host cell metabolic reprogramming and tumorigenesis by targeting vital enzymes or regulators. This study aims to explore the role of wild-type isocitrate dehydrogenase 2 (IDH2) in induced EBV-encoded latent membrane protein 1 (LMP1). Mechanistic dissection IDH2 EBV-LMP1-induced was investigated using western blotting, real-time polymerase chain reaction (PCR), immunochemistry, chromatin immunoprecipitation (ChIP),...
Mitochondrial isocitrate dehydrogenase 2 (IDH2) is an important metabolic enzyme in the tricarboxylic acid cycle (TCA) cycle. Our previous study showed that high expression of wild-type IDH2 promotes proliferation lung cancer cells. This aims to test potential targeting as a therapeutic strategy inhibit vitro and vivo. First, we analyzed available data from databases gene omnibus (GEO) database evaluate clinical relevance affecting patient survival. We then generated stable IDH2-knockdown...
Lung cancer is the most common leading cause of cancer-related death worldwide. Late diagnosis contributes to a high mortality rate and poor survival this cancer. In our previous study, we found that IDH2 polymorphism rs11540478 risk factor for lung Here, examined protein expression in culture medium which two non-small-cell (NSCLC) cell lines, H460 A549, were growing. We was elevated supernatant fraction time- number-dependent manner. Next, used ELISA methods examine level serum from...
Recently, mutations in isocitrate dehydrogenase 1/2 (IDH1/2) were discovered 70% of low-grade glioma and secondary glioblastoma multiforme. The discovery an oncogenic function the identification onco-metabolites IDH1/2 support new roles for metabolism cancer. For example, some evidence indicates that IDH2 might also exhibit functions by promoting cellular cancer cell growth. We examined association between rs11540478 lung risk 262 patient cases 602 healthy control subjects investigated...
A pulse-radiating bow-tie antenna with enhanced electric-field focusing property in the near field is studied. The achieved by placing an ellipsoid reflector around antenna. section of microstrip reflection line combined a photoconductive semiconductor switches designed as source to generate short pulse for excitation. In simulations, surrounding circumstance between and modeled water match real cellular environment. Results show that electric intensities proposed parabolic at 16 cm 31cm...