A5101742139- Cancer, Hypoxia, and Metabolism
- Natural product bioactivities and synthesis
- RNA modifications and cancer
- Ginseng Biological Effects and Applications
- Advanced Steganography and Watermarking Techniques
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Peroxisome Proliferator-Activated Receptors
- Vehicle License Plate Recognition
- Genomic variations and chromosomal abnormalities
- Advanced Proteomics Techniques and Applications
- Nanoplatforms for cancer theranostics
- Autophagy in Disease and Therapy
- Bacteriophages and microbial interactions
- Bee Products Chemical Analysis
- Phagocytosis and Immune Regulation
- Biometric Identification and Security
- Agricultural risk and resilience
- Circular RNAs in diseases
- Glycosylation and Glycoproteins Research
- Image and Video Stabilization
- Forecasting Techniques and Applications
- Particle Detector Development and Performance
- Urological Disorders and Treatments
Hubei University of Chinese Medicine
2024
Zhejiang University
2024
First Hospital of Shijiazhuang
2024
Tiangong University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2023
Wenzhou Medical University
2021-2022
Central South University
2019-2022
Xiangya Hospital Central South University
2019-2022
Nasopharyngeal carcinoma (NPC) has a particularly high prevalence in southern China, southeastern Asia and northern Africa. Radiation resistance remains serious obstacle to successful treatment NPC. This study aimed explore the metabolic feature of radiation-resistant NPC cells identify new molecular-targeted agents improve therapeutic effects radiotherapy Methods: Radiation-responsive were used as model system vitro vivo. Metabolomics approach was illustrate global changes. 13C isotopomer...
Abstract As the first rate-limiting enzyme in fatty acid oxidation (FAO), CPT1 plays a significant role metabolic adaptation cancer pathogenesis. FAO provides an alternative energy supply for cells and is required cell survival. Given high proliferation rate of cells, nucleotide synthesis gains prominence rapidly proliferating cells. In present study, we found that CPT1A determining factor abnormal activation nasopharyngeal carcinoma (NPC) highly expressed NPC biopsies. dramatically affects...
The PPAR coactivator‐1α (PGC1α) is an important transcriptional co‐activator in control of fatty acid metabolism. Mitochondrial oxidation (FAO) the primary pathway for degradation acids and promotes NADPH ATP production. Our previous study demonstrated that upregulation carnitine palmitoyl transferase 1 A (CPT1A), key regulator FAO, radiation resistance nasopharyngeal carcinoma (NPC). In this study, we found high expression PGC1α associated with poor overall survival NPC patients after...
EBV infection is a recognized epigenetic driver of carcinogenesis. We previously showed that could protect cancer cells from TNF-induced necroptosis. This study aims to explore the mechanisms allowing with escape RIP3-dependent Methods: Data TCGA database were used evaluate prognostic value RIP3 promoter methylation and its expression. Western blotting, real-time PCR, immunochemistry conducted investigate relationship between LMP1 in cell lines NPC tissues. BSP, MSP hMeDIP assays examine...
The development of improved or targeted drugs that discriminate between normal and tumor tissues is the key therapeutic issue in cancer research.However, an analytical method with a high accuracy sensitivity to achieve quantitative assessment targeting anticancer even intratumor heterogeneous distribution these at early stages drug research major challenge.Mass spectrometry imaging label-free molecular technique provides spatial-temporal information on metabolites organisms, its application...
Against tumor-dependent metabolic vulnerability is an attractive strategy for tumor-targeted therapy. However, inhibitors are limited by the drug resistance of cancerous cells due to their plasticity and heterogeneity. Herein, choline metabolism was discovered spatially resolved metabolomics analysis as which highly active in different cancer types, a choline-modified small molecule-drug conjugates (SMDCs) design developed fool tumor into indiscriminately taking chemotherapy drugs targeted...
Abstract The intracellular distribution and transportation process are essential for maintaining PD‐L1 (programmed death‐ligand 1) expression, intervening in this cellular may provide promising therapeutic strategies. Here, through a cell‐based high content screening, it is found that the ABCB1 (ATP binding cassette subfamily B member modulator zosuquidar dramatically suppresses expression by triggering its autophagic degradation. Mechanistically, interacts with impairs COP II‐mediated...
Despite prophylactic vaccination campaigns, high-risk human papillomavirus (HPV)-induced cervical cancer remains a significant health threat among women, especially in developing countries. The initial occurrence and consequent progression of this type primarily rely on, E6 E7, two key viral oncogenes expressed constitutively, inducing carcinogenesis. Thus, E6/E7 have been proposed as ideal targets for HPV-related diagnosis treatment. In study, three novel HPV16 E6-binding affibody molecules...
Objective: Parthenolide (PTL) induces anti-tumor effects via the nuclear factor kappa B (NF-κB) signaling pathway. MCL3, a PTL derivative, is sesquiterpene lactone synthesized by rearrangement and subsequent oxidation of PTL. The aim this study was to elucidate antitumor activity mechanism action MCL3 in glioblastoma (GBM). Materials Methods: on G422 cell proliferation, apoptosis, invasion, angiogenesis vitro were measured using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide...
A biosynthetic ginsenoside, 3-O-β-D-glucopyranosyl-12-O-β-D-glucopyranosyl-dammar-24-ene-3β, 12β, 20S-triol (C3C12PPD), showed antitumor activity against many tumor cells in vitro, especially had better anti-lung cancer than Rg3 vitro and vivo. However, the effects molecular mechanisms of C3C12PPD on non-small cell lung (NSCLC) remain unclear. According to previous studies, we hypothesized ginsenoside could inhibit growth NSCLC by targeting proliferation, migration angiogenesis.A thiazolyl...
Objective: Nonsmall-cell lung cancer (NSCLC) is an aggressive, highly chemoresistant disease. Taxol effective chemotherapeutic drug widely used for the treatment of NSCLC. However, clinical use limited due to occurrence adverse side effects under high therapeutic doses. Therefore, it desirable explore combination therapy reduce dose drugs and achieve excellent outcomes. A biosynthetic ginsenoside, 3-O-β-D-glucopyranosyl-dammar-24-ene-3β, 20S-diol (3β-O-Glc-DM, C3DM) obtained from microbial...
Affibodies targeting intracellular proteins have a great potential to function as ideal therapeutic agents. However, little is known about how the affibodies enter target cells interact with proteins. We previously developed HPV16E7 affibody (ZHPV16E7384) for HPV16 positive cervical cancer treatment. Here, we explored underlying mechanisms of ZHPV16E7384 and found that significantly inhibited proliferation induced G1/S phase cell cycle arrest. Furthermore, treatment resulted in upregulation...
ABSTRACT Circular RNAs (circRNAs) are implicated in the progression of breast cancer (BC). However, explorations on circRNA IQ motif containing H (circIQCH) BC remain limited. Functional experiments were conducted using vitro and murine xenograft model assays, respectively. Dual‐luciferase reporter assay RIP detected associations among circIQCH, miR‐139‐5p, nuclear factor IB (NFIB). CircIQCH was upregulated BC, silencing circIQCH repressed cell growth, metastasis, autophagy, arrested cycle,...
The hedgehog (HH) signaling pathway is abnormally activated in glioblastoma (GBM); thus, its downstream effector GLI1 may be a suitable target for the treatment of GBM. aim present study was to evaluate antitumor activities novel compound, FL34, GBM through inhibition GLI1.The effect FL34 on suppressing proliferation, angiogenesis, and invasion cells investigated vitro using invasion, tube formation, flow cytometry, dual luciferase, reverse transcription-quantitative polymerase chain...