A5100741383- Cancer-related gene regulation
- Metamaterials and Metasurfaces Applications
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Wnt/β-catenin signaling in development and cancer
- Antenna Design and Analysis
- Angiogenesis and VEGF in Cancer
- Cancer-related molecular mechanisms research
- Advanced Antenna and Metasurface Technologies
- Cellular transport and secretion
- Salivary Gland Disorders and Functions
- Bioactive Compounds and Antitumor Agents
- Phytoestrogen effects and research
- Plant and Fungal Species Descriptions
- Venomous Animal Envenomation and Studies
- Coleoptera Taxonomy and Distribution
- Scarabaeidae Beetle Taxonomy and Biogeography
- Orbital Angular Momentum in Optics
- Antioxidant Activity and Oxidative Stress
- Metabolomics and Mass Spectrometry Studies
- ATP Synthase and ATPases Research
- Gout, Hyperuricemia, Uric Acid
- Advanced Image Processing Techniques
Shandong University
2024
Yunnan Normal University
2024
Sun Yat-sen University
2024
The Seventh Affiliated Hospital of Sun Yat-sen University
2024
Southern Medical University
2024
Harbin Medical University
2006-2023
Third Affiliated Hospital of Harbin Medical University
2011-2023
University of Science and Technology of China
2022-2023
Yokohama National University
2018-2022
Heilongjiang Academy of Sciences
2022
Pyroptosis is a new form of programmed cell death generated by some inflammasomes, piloting the cleavage gasdermin (GSDM) and stimulation dormant cytokines like IL-18 IL-1β; these reactions are narrowly linked to certain diseases diabetic nephropathy atherosclerosis. Doxorubicin, typical anthracycline, famous anticancer drug has emerged as prominent medication in several cancer chemotherapies, although its application accompanied with expending dose-dependent, increasing, irreversible...
Succinate dehydrogenase (SDH) is a heterotetrameric enzyme complex belonging to the mitochondrial respiratory chain and uniquely links tricarboxylic acid (TCA) cycle with oxidative phosphorylation. Cancer-related SDH mutations promote succinate accumulation, which regarded as an oncometabolite. Post-translational modifications of components are known regulate activity, although contribution SUMOylation remains unclear. Here, we show that SDHA SUMOylated by PIAS3 deSUMOylated SENP2, events...
Regressing the accelerated degradation of skeletal muscle protein is a significant goal for cancer cachexia management. Here, we show that genetic deletion Pgam5 ameliorates atrophy in various tumor-bearing mice. pgam5 ablation represses excessive myoblast mitophagy and effectively suppresses mitochondria meltdown wastage. Next, define BNIP3 as receptor constitutively associating with PGAM5. bnip3 restricts body weight loss enhances gastrocnemius mass index age- tumor size-matched...
Abstract Background and Objective As a chronic inflammatory disease, periodontitis threatens oral health is risk factor for Alzheimer's disease (AD). There growing evidence that these two diseases are closely related. However, current research still incomplete in understanding the common genes mechanisms between AD. In this study, we aimed to identify AD analyze relationship crucial immune cells provide new therapeutic targets clinical treatment. Materials Methods We evaluated differentially...
Holography is an advanced imaging technology where image information can be reconstructed without a lens. Recently, multiplexing techniques have been widely adapted to realize multiple holographic images or functionalities in meta-hologram. In this work, reflective four-channel meta-hologram proposed further increase the channel capacity by simultaneously implementing frequency and polarization multiplexing. Compared single technique, number of channels achieves multiplicative growth two...
Homeobox D3 (HOXD3) is a member of the homeobox family genes that known primarily for its transcriptional regulation morphogenesis in all multicellular organisms. In this study, we sought to explore role HOXD3 plays stem-like capacity, or stemness, and drug resistance breast cancer cells.Expression clinical samples were examined by RT-PCR immunohistochemistry. expression cell lines analyzed western blot. Ability cells elevated MTT viability colony formation assays. We stemness using...
Breast cancer (BC) remains a significant threat to the health of women; however, mechanism underlying initiation and progression BC is poorly understood. We analyzed data from Gene Expression Omnibus database The Cancer Genome Atlas datasets identify differentially expressed genes between normal tissues. roles dCTP pyrophosphatase 1 (DCTPP1) quinolinate phosphoribosyltransferase (QPRT) in cells were investigated after knocking down or overexpressing genes. regulatory effects Down syndrome...
Metasurfaces are engineered planar surfaces consisting of arrays resonators for tailoring the electromagnetic wavefronts in a desirable way. However, spin-locked issue geometric metasurfaces hinders simultaneous manipulation both spins. In this work, spin-decoupled information metasurface composed simple C-shaped is proposed to realize two different channels under orthogonal circularly polarized (CP) incidences. Based on encoded digit '0' or '1', diffusion scattering holographic image could...
AbstractIn this study, questionnaire surveys and field measurements were conducted at houses with elderly people in urban rural areas across six regions of China. The prevalence hypertension was approximately 40% both areas. logistic analysis results indicated a greater the residences low indoor temperature-induced hypertension. According to measurement survey, room temperature stable around 23 °C housing northern equipped district heating systems, fluctuated from being equivalent outdoor 15...
Abstract Holography based on optical metasurfaces has attracted a steadily increasing interest. However, most of the usually suffer from limited number and fixed viewing angles multiplexed holography images in one channel. Here, by modifying Gerchberg–Saxton algorithm, at arbitrary‐planes is proposed two arbitrary microwave frequency bands. As proof‐of‐concept demonstration, independent information channels can be established single metasurface through dual‐frequency meta‐atoms. The composed...
The activation of the Wnt/β-catenin signaling pathway has been demonstrated to play important roles in breast carcinogenesis and be associated with a poorer prognosis cancer patients. However, genetic mutation is not major reason for cancer. Dishevelled-associated antagonist β-catenin homolog 2 (DACT2) negative regulator acts as tumor suppressor numerous types; however, expression change potential role DACT2 unknown. present study detected function progression. It was identified that...
As cancer has become a worldwide threat to human life and health, developing safe effective tumor-inhibiting agent is presently major scientific challenge. In this study, food mixture produced from 55 different natural ingredients called wushen was fed S180 tumor-bearing mice, the antitumor effects were investigated in vivo. Kunming mice implanted subcutaneously armpit with murine sarcoma cells construct mouse model. The randomly divided into three groups: control, 5-fluorouracil (5-Fu)....
Affibodies targeting intracellular proteins have a great potential to function as ideal therapeutic agents. However, little is known about how the affibodies enter target cells interact with proteins. We previously developed HPV16E7 affibody (ZHPV16E7384) for HPV16 positive cervical cancer treatment. Here, we explored underlying mechanisms of ZHPV16E7384 and found that significantly inhibited proliferation induced G1/S phase cell cycle arrest. Furthermore, treatment resulted in upregulation...
Folium
Norendoxifen, an active metabolite of tamoxifen, is a potent aromatase inhibitor. Little information available regarding production norendoxifen in vitro. Here, we conducted series kinetic and inhibition studies human liver microsomes (HLMs) expressed P450s to study the metabolic disposition norendoxifen. To validate that was endoxifen, metabolites HLMs incubates endoxifen were measured using HPLC/MS/MS method. further probe specific isoforms involved route, incubated with recombinant (CYP...
Recently a number of preclinical studies have sparked interest in the concept exploiting conventional chemotherapeutic drugs as antiangiogenics. Such antiangiogenic activity is achieved by metronomic-dosing (low-dose) protocols. This new target may some advantages avoiding toxicity and resistance caused drugs. study to test efficacy continuous low-dose cyclophosphamide (CTX) for effect on Lewis lung carcinoma, investigate its antitumor toxicity.C57/BL6 mice bearing carcinoma were randomly...
Abstract Hepatitis B virus (HBV) infection (surface antigen positive, HBsAg+) has been linked to the increased risk and poor prognosis for B-cell lymphoma. Here, we aimed discover distinctive potential factors influence in HBV-associated follicular lymphoma (FL). Retrospective investigation from multiple clinical centers showed that patients with HBsAg+ FL were featured a higher incidence of disease progression within 24 months (POD24, P=0.031), shorter progression-free survival (PFS, P =...
<h3>Background</h3> Hepatitis B virus (HBV) infection (surface antigen positive, HBsAg+) has been linked to the increased risk and poor prognosis for B-cell lymphoma. Here, we aimed explore clinically applicable prognostic index in HBV-associated follicular lymphoma (FL). <h3>Methods</h3> Retrospective investigation was performed clinical features from three centers China. We used Human Methylation 850K BeadChip platform detect DNA methylation signatures HBsAg+ tumors occurring POD24 after...