A5101528173- Global Public Health Policies and Epidemiology
- Renal Diseases and Glomerulopathies
- Systemic Lupus Erythematosus Research
- Advanced Breast Cancer Therapies
- Effects and risks of endocrine disrupting chemicals
- Skin Protection and Aging
- RNA modifications and cancer
- Carcinogens and Genotoxicity Assessment
- Healthcare Systems and Public Health
- Genomics and Rare Diseases
- Vasculitis and related conditions
- Liver Disease Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Immunodeficiency and Autoimmune Disorders
- Bone Metabolism and Diseases
- Connective tissue disorders research
- Climate Change and Health Impacts
- interferon and immune responses
- Cell Adhesion Molecules Research
- Global Health Care Issues
- Peptidase Inhibition and Analysis
- Computational Drug Discovery Methods
- Genomics, phytochemicals, and oxidative stress
- Kawasaki Disease and Coronary Complications
- Health, Environment, Cognitive Aging
Shanghai Children's Medical Center
2014-2025
Anhui Academy of Agricultural Sciences
2025
University of Arizona
2019-2024
Shanghai Jiao Tong University
2014-2024
Fujian Provincial Hospital
2020-2024
Second Military Medical University
2014-2023
Shanghai Pudong New Area Gongli Hospital
2023
Weatherford College
2023
Lee's Pharmaceutical (China)
2018-2022
Harbin Medical University
2020-2022
Abstract Many inorganic nanoparticles are prepared and their behaviors in living systems investigated. Yet, common electrolytes such as NaCl left out of this campaign. The underlying assumption is that electrolyte will quickly dissolve water behave similarly constituent salts. Herein, preconception challenged. study shows (SCNPs) but not salts highly toxic to cancer cells. This because SCNPs enter cells through endocytosis, bypassing cell regulations on ion transport. When dissolved inside...
Background: Tobacco smoking, similar to ultraviolet (UV) A radiation exposure, has previously been identified as an important factor contributing premature aging of human skin. Objective and design: To investigate the relationship between these two environmental factors, we have conducted a cross‐sectional study 83 subjects (48 males, 35 females, age range 23–95), in which sun pack‐years smoking history potential confounding variables were assessed by questionnaire. Facial wrinkles...
This study aimed to comprehensively evaluate the toxicity exerted by zinc oxide nanoparticles (ZnO NPs) on rat testis and its effects fertility progeny development.Different concentrations of ZnO NPs were administered gavage Sprague Dawley (SD) rats examine adverse resulting from pre- post-natal exposure. Systemic distribution NPs, developmental performance, sperm parameters, reproductive histopathological examination, sex hormone levels determined scheduled in experimental their male...
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease which affected by the environmental, genetic factors as well immune system. Previous reports have implicated IFN-α in pathogenesis of SLE. Up to date, however, no research has ever investigated effect on CD8+T cells, might be In present study, we aimed explore pathologic role regard dysfunction cells Serum level was detected SLE and healthy controls (HC). Surface expression lysosome-associated membrane protein 1...
To analyse the clinical features of Henoch-Schönlein purpura (HSP) with or without nephritis in Chinese children and to determine risk factors for renal involvement.Patient characteristics, parameters laboratory data were retrospectively analysed patients HSP nephritis. Logistic regression analysis was used identify involvement.A total 535 included study. occurred 267 (49.9%), ranging from isolated haematuria 5.2%, mild proteinuria 77.5%, moderate 6.4% severe 10.9% cases. In 90% cases,...
Abstract We have recently shown that tobacco smoking, like ultraviolet A radiation, is an important factor contributing to premature skin aging. found smoke extract decreased type I and III procollagen, increased tropoelastin mRNA, induced abnormal accumulation of proteoglycans matrix metalloproteinase (MMP)‐1 MMP‐3 in cultured fibroblasts. This indicated common molecular features might underlie the aging by extract, including regulation extracellular deposition through elevated MMPs,...
Increasing evidence suggests a role for apoptosis in the maintenance of alveolar epithelium under normal and pathological conditions. However, signaling pathways modulating type II (AT II) cell remain poorly defined. Here we investigated lysosomes as modulators oxidant-mediated AT using an vitro model H(2)O(2)-stress. H(2)O(2) stress led to time-dependent increases intracellular oxidants, mitochondrial membrane polarization, cytochrome c release, lysosomal rupture, cells apoptosis. Increased...
Lamins are nuclear intermediate filament proteins that comprise the major components of lamina. Mutations in LMNA, which encodes lamins A/C, cause laminopathies, including lipodystrophy, cardiomyopathy, and premature aging syndromes. However, role liver is unknown, it unclear whether laminopathy-associated disease caused by primary hepatocyte defects or systemic alterations.To address these questions, we generated mice carrying a hepatocyte-specific deletion Lmna (knockout [KO] mice)...
Antimicrotubule agent vincristine (VCR) has long been known as an alternative treatment for frequent relapse nephrotic syndrome and steroid-dependent (SDNS). However, the mechanism is unknown. Here we found that VCR at a dosage much lower than antimicrotubule can alleviate adriamycin (ADR)-induced proteinuria podocyte foot process effacement. In cultured podocytes, prevents ADR-induced actin fiber disorganization. both in vitro vivo models, suppresses overexpression of α3β1 integrin focal...
To determine the incidence and clinical features of paediatric primary vasculitis in patients from one centre Eastern China.Medical records diagnosed with between January 1999 December 2013 were retrospectively reviewed. For Henoch-Schönlein purpura (HSP) Kawasaki disease (KD), included analyses had data available for previous 5 years.In total, 1896 identified, whom 1100 HSP, 760 KD, 23 Takayasu arteritis, five polyarteritis nodosa, four cutaneous polyarteritis, three Behçet's microscopic...
The epitranscriptomic writer Alkylation Repair Homolog 8 (ALKBH8) is a transfer RNA (tRNA) methyltransferase that modifies the wobble uridine of selenocysteine tRNA to promote specialized translation selenoproteins. Using Alkbh8 deficient (Alkbh8def) mice, we have investigated importance systems in response naphthalene, an abundant polycyclic aromatic hydrocarbon and environmental toxicant. We performed basal lung analysis naphthalene exposure studies using wild type (WT), Alkbh8def...
Abstract The excessive deposition of collagen in systemic sclerosis (SSc) is thought to be due an abnormal function fibroblasts, which may the result immune dysregulation skin. Ultraviolet A1 (UVA1) irradiation has been shown effective therapy. This its capacity induce matrix metalloproteinase‐1 (MMP‐1) expression human dermal fibroblasts. In present vitro study, effect UVA1 on MMP‐1 was studied using skin fibroblasts from healthy controls (n=5) and patients with (n=5). studies showed that...
Primary testicular cell coculture model has been used to evaluate abnormalities during development, and was able identify the toxicity of phthalates. However, primary disadvantages in employing animals for isolation cells, complicated procedure leads inconsistent results. We developed an invitro from rodent lines, including spermatogonial Sertoli Leydig cells with specified density extracellular matrix (ECM) composition. Using comparative high-content analysis F-actin cytoskeletal structure...