A5010735364- Electromagnetic Fields and Biological Effects
- Effects of Radiation Exposure
- Photoreceptor and optogenetics research
- Human Health and Disease
- Nicotinic Acetylcholine Receptors Study
- Spaceflight effects on biology
- Neuroscience and Neuropharmacology Research
- Mitochondrial Function and Pathology
- Cancer, Hypoxia, and Metabolism
- Ultrasound and Hyperthermia Applications
- Hydrogen's biological and therapeutic effects
- Anesthesia and Neurotoxicity Research
- MicroRNA in disease regulation
- Wireless Body Area Networks
- Noise Effects and Management
- Biofield Effects and Biophysics
- Selenium in Biological Systems
- Neurogenesis and neuroplasticity mechanisms
- Molecular Communication and Nanonetworks
- PARP inhibition in cancer therapy
- Cancer Mechanisms and Therapy
- Hepatitis B Virus Studies
- Terahertz technology and applications
- Metabolomics and Mass Spectrometry Studies
- Ferroptosis and cancer prognosis
Beijing Radiation Center
2015-2025
Henan University of Technology
2025
China Agricultural University
2024-2025
Nanjing Tech University
2024
Sun Yat-sen University
2024
Sun Yat-sen University Cancer Center
2024
Hebei University
2024
Academy of Military Medical Sciences
2009-2023
Following traumatic brain injury (TBI), inhibition of the Na+-K+-Cl- cotransporter1 (NKCC1) has been observed to alleviate damage blood-brain barrier (BBB). However, underlying mechanism for this effect remains unclear. This study aimed investigate mechanisms by which inhibiting NKCC1 attenuates disruption BBB integrity in TBI. The TBI model was induced C57BL/6 mice through a controlled cortical impact device, and an vitro established using Transwell chambers. Western blot (WB) analysis used...
With the rapid development of electronic technologies, anxiety regarding potential health hazards induced by microwave radiation (MW) has been growing in recent years. The brain is one most sensitive target organs for radiation, where mitochondrial injury occurs earlier and more severely than other organs. Energy metabolism disorders do play an important role during process radiation-induced damage. In this paper, we will review biological effects features energy supply consumption on...
<h3>Background</h3> Human hepassocin (HPS) was originally detected by subtractive and differential cDNA cloning as a liver-specific gene that markedly upregulated during liver regeneration. Previous studies suggested HPS showed mitogenic activity on isolated hepatocytes in vitro. However, its vivo functions remained largely unknown. Therefore, the function of recombinant human regeneration chemically induced injury investigated. <h3>Methods</h3> The proliferation primary examined...
To assess the impact of microwave exposure on learning and memory to explore underlying mechanisms.100 Wistar rats were exposed a 2.856 GHz pulsed field at average power densities 0 mW/cm(2), 5 10 mW/cm(2) 50 for 6 min. The spatial was assessed by Morris Water Maze (MWM) task. An in vivo study conducted soon after evaluate changes population spike (PS) amplitudes long-term potentiation (LTP) medial perforant path (MPP)-dentate gyrus (DG) pathway. structure hippocampus observed light...
To determine whether microwave (MW) radiation induces neural cell apoptosis, differentiated PC12 cells and Wistar rats were exposed to 2.856GHz for 5min 15min, respectively, at an average power density of 30 mW/cm 2 .JC-1 TUNEL staining detected significant apoptotic events, such as the loss mitochondria membrane potential DNA fragmentation, respectively.Transmission electron microscopy Hoechst used observe chromatin ultrastructure body formation.Annexin V-FITC/PI double was quantify level...
Abstract Many studies have revealed the cognitive decline induced by microwave radiation. However, systematic study on dose-dependent, frequency-dependent and accumulative effects of exposure at different frequencies was lacking. Here, we studied relationship between power frequency analyzed two microwaves with same average density. After radiation, declines in spatial learning memory fluctuations brain electric activities were found 10 mW/cm 2 single groups groups. Meanwhile, morphological...
The anxieties and concerns about health hazards caused by microwave has been growing recently. Previous studies have reported induced structural functional injuries to brain. However, the biological effects compound were largely unexplored. In this study, we investigated on rat's hippocampus after sequentially exposure 2.8 GHz 9.3 at average power density of 10 mW/cm2. Morris water maze (MWM) navigation tests showed that significantly extended escape latency (AEL) 1d 3d exposure, suggesting...
Highly efficient linkage of readily available nucleophilic building blocks under mild conditions is essential for the synthesis drug discovery and materials, yet it remains challenging due to often unavoidable tendency homo-coupling side reactions using traditional linkers. In this study, we present a versatile switchable SuFEx linker chemistry, exemplified by ESF, which enables highly selective coupling thiols, alcohols, selenols with O-/N-nucleophiles. This strategy harnesses unique...
β-Sultams are recognized as potential antibacterial agents and crucial building blocks in chemical synthesis. Herein, a "SuFEx on silica gel" approach has been developed for one-step synthesis of β-sultams utilizing readily available amines ethenesulfonyl fluoride (ESF). This process involves sequential Michael addition to ESF, followed by an intramolecular SuFEx reaction promoted gel. Silica gel facilitates the activation sulfonyl through hydrogen bonding between SVI-F surface hydroxyl...
Forkhead box M1 (FoxM1) transcription factor is related to the pathogenesis of various malignancies and recent evidence indicates that FoxM1 promotes epithelial-mesenchymal transition (EMT) in breast cancer. Metformin can inhibit progression However, whether plays a role EMT prostate cancer (PCa) metformin suppress through PCa remain unresolved issues. In this study, we investigated expression levels protein 62 39 benign hyperplasia (BPH) samples found were higher tissues (66.1%) compared...
The terahertz (THz) band lies between microwave and infrared rays in wavelength consists of non-ionizing radiation. Both domestic foreign research institutions, including the army, have attached considerable importance to development THz technology because this radiation exhibits both photon-like electron-like properties, which grant it application value potential. With rapid related applications, studies biological effects become a major focus field life sciences. Research has only just...
The exogenous application of low-intensity electric stimulation (ES) may mimic a natural endogenous bioelectric current and accelerate the repair process skin wounds. This study designed novel microcurrent dressing (MCD) evaluated its potential effects on wound healing in rat defect model.First, wireless ES was integrated into medical cotton cushion to fabricate MCD, electrical property examined by using universal power meter. Then, animal experiments were conducted evaluate MCD's effect....
Although some epidemiological investigations showed a potential association between long-term exposure of extremely low frequency electromagnetic fields (ELF-EMF) and Alzheimer's disease (AD), no reasonable mechanism can explain this association, the related animal experiments are rare. In study, ELF-EMF (50Hz 400µT 60d) combined with D-galactose intraperitoneal (50mg/kg, q.d., 42d) Aβ25–35 hippocampal (5μl/unilateral, bilateral, single-dose) injection was implemented to establish complex...
Previous studies have shown that single-frequency microwave radiation can lead to cognitive decline in rats. However, few focused on the combined effects of irradiation with different frequencies microwaves. Our research aimed investigate 1.5 GHz and 4.3 radiation, singly combination, function hippocampal tissue structure A total 140 male Wistar rats were randomly divided into 4 groups: S group (sham group), L10 (10 mW/cm2 C10 band group) LC10 multi-frequency group). For 1-28 days after we...