A5101540206- MicroRNA in disease regulation
- Inflammatory Bowel Disease
- Wound Healing and Treatments
- Planarian Biology and Electrostimulation
- Circular RNAs in diseases
- Microscopic Colitis
- RNA Research and Splicing
- Clostridium difficile and Clostridium perfringens research
- Diverticular Disease and Complications
- Corneal Surgery and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Antibiotic Use and Resistance
- Autoimmune and Inflammatory Disorders
- Computational Drug Discovery Methods
- Nosocomial Infections in ICU
- Cancer Mechanisms and Therapy
- Burn Injury Management and Outcomes
- Bioinformatics and Genomic Networks
- Plant and Biological Electrophysiology Studies
- Colorectal Cancer Surgical Treatments
- Proteoglycans and glycosaminoglycans research
- Immune Cell Function and Interaction
Zhejiang University
2019-2024
Zhejiang Lab
2024
Zunyi Medical University
2023
Beijing Radiation Center
2014
Nanjing University
2011
Nanjing General Hospital of Nanjing Military Command
2011
The exogenous application of low-intensity electric stimulation (ES) may mimic a natural endogenous bioelectric current and accelerate the repair process skin wounds. This study designed novel microcurrent dressing (MCD) evaluated its potential effects on wound healing in rat defect model.First, wireless ES was integrated into medical cotton cushion to fabricate MCD, electrical property examined by using universal power meter. Then, animal experiments were conducted evaluate MCD's effect....
Circular RNAs (circRNAs) play a critical regulatory role in degenerative diseases; however, their functions and therapeutic applications intervertebral disc degeneration (IVDD) have not been explored. Here, we identified that novel circATXN1 highly accumulates aging nucleus pulposus cells (NPCs) accountable for IVDD. CircATXN1 accelerates cellular senescence, disrupts extracellular matrix organization, inhibits mitochondrial respiration. Mechanistically, circATXN1, regulated by heterogeneous...
Early diagnosis of hepatocellular cancer (HCC) significantly helps improve patient survival. However, high specific and sensitive tests for screening patients with early stage HCC are not yet available. Novel biomarkers based on gene expression profiles peripheral blood mononuclear cells (PBMCs) might change the situation. Recently, a three gene-based signature non-invasive detection was reported.To compare differences in global PBMCs healthy individuals patients, aim to uncover altered...
Objective Recent genome‐wide association studies have demonstrated that rs2236379 in PRKCQ is a novel significant locus for Crohn's disease (CD). However, the has not been replicated any populations. We therefore aimed to investigate prevalence of variant Chinese Han population and evaluate whether genetic confers susceptibility CD associated with its clinical characteristics. Methods A total 283 patients 381 healthy controls were enrolled. Genomic DNA was extracted from their whole blood...
The replicative senescence of human amniotic epithelial stem cells (hAECs) is a major concern towards its clinical application. This study found that 300-kDa hyaluronic acid (HA) could effectively delay the hAECs, as indicated by downregulation cellular markers and alteration cell cycle, substantially improve differentiation capacities hAECs. HA was confirmed to regulate CD44 isoform switch upregulating CD44s downregulating CD44v, thus exerting an anti-aging effect. We further induced...
Objective To investigate the effects and mechanism of expression microRNA-100 in tissues pancreatic cancer its relationship with clinicopathological factor. Methods The clinical data 17 patients who were admitted to Affiliated Hospital Guizhou Medical University between January 2013 March 2014 retrospectively analyzed. The surgical specimens collected for study. detected by real-time fluorescent quantitative polymerase chain reaction (RT-PCR) factors was MIA PaCa-2 cells CFPAC-1...