A5101633522- Insect Resistance and Genetics
- Bone Metabolism and Diseases
- Genomics, phytochemicals, and oxidative stress
- Viral Infectious Diseases and Gene Expression in Insects
- RNA Interference and Gene Delivery
- Bone health and treatments
- Tendon Structure and Treatment
- Biopolymer Synthesis and Applications
- CRISPR and Genetic Engineering
- MicroRNA in disease regulation
- Cellular Mechanics and Interactions
- Insect and Pesticide Research
- Entomopathogenic Microorganisms in Pest Control
- Virus-based gene therapy research
- Moringa oleifera research and applications
- Sports injuries and prevention
- Plant Surface Properties and Treatments
- Glutathione Transferases and Polymorphisms
- Energy and Environment Impacts
- Cancer-related molecular mechanisms research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Insect symbiosis and bacterial influences
- Microtubule and mitosis dynamics
- RNA and protein synthesis mechanisms
- Neurogenesis and neuroplasticity mechanisms
Zhengzhou University
2023-2025
Zhejiang Lab
2021-2024
Second Affiliated Hospital of Zhejiang University
2020-2024
First Affiliated Hospital of Zhengzhou University
2022-2024
Zhejiang University
2020-2024
Blood Center of Zhejiang Province
2024
Zhejiang University Medical College Affiliated Stomatological Hospital
2020-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
Xiyuan Hospital
2021
Chinese Academy of Sciences
2013-2020
Integrin and focal adhesion can regulate cytoskeleton distribution to govern actin-related force remodeling play an important role in nuclear configuration force-sensing mechanotransduction of stem cells. However, further exploration the interaction between actinin complex myosin, kinetics, molecular mechanism structures nucleate within engineered cells is vague. An extensive comprehension cell morphogenesis, remodeling, essential reveal basic physical principles polymerization force-related...
Tendon injuries are some of the most commonly diagnosed musculoskeletal diseases. regeneration is sensitive to topology substitute as it affects cellular microenvironment and homeostasis. To bionic in vivo three-dimensional (3D) aligned microenvironment, an ordered 3D sandwich model was used investigate cell response tendon. First, high-resolution printing provided parallel-grooved topographical cues on hydrogel surface. Then cells were seeded its surface acquire a 2D model. Afterward,...
Abstract The lack of periosteum in bone allografts is considered a major cause graft failure; however, the currently used artificial has failed to proactively adapt its chronological role repair process. This study designed an adaptive periosteal system with dual‐response mechanisms enable interactive angiogenic/osteogenic stimulation customized for inflammatory and anabolic stages healing. Utilizing enzymatic reactions photodynamic properties gold nanorod‐porous silicon, angiogenic peptides...
Long-term chronic inflammation after Achilles tendon injury is critical for tendinopathy. Platelet-rich plasma (PRP) injection, which a common method treating tendinopathy, has positive effects on repair. In addition, tendon-derived stem cells (TDSCs), are located in tendons, play major role maintaining tissue homeostasis and postinjury this study, injectable gelatine methacryloyl (GelMA) microparticles containing PRP laden with TDSCs (PRP-TDSC-GM) were prepared by projection-based 3D...
Circular RNAs (circRNAs) play a critical regulatory role in degenerative diseases; however, their functions and therapeutic applications intervertebral disc degeneration (IVDD) have not been explored. Here, we identified that novel circATXN1 highly accumulates aging nucleus pulposus cells (NPCs) accountable for IVDD. CircATXN1 accelerates cellular senescence, disrupts extracellular matrix organization, inhibits mitochondrial respiration. Mechanistically, circATXN1, regulated by heterogeneous...
Osteoarthritis is a worldwide joint disease caused by abnormal chondrocytic metabolism. However, traditional therapeutic methods aimed at anti-inflammation for early-stage are palliative. In the present study, we demonstrated that cepharanthine (CEP), extracted from plant Stephania cepharantha, exerted protective medicinal efficacy on osteoarthritis first time. our in vitro CEP suppressed elevated expression of matrix metalloproteinases (MMPs), disintegrin and metalloproteinase with...
Glutathione S-transferase P1(GSTP1) is known for its transferase and detoxification activity. Based on disease-phenotype genetic associations, we found that GSTP1 might be associated with bone mineral density through Mendelian randomization analysis. Therefore, this study was performed both in vitro cellular vivo mouse model to determine how affects homeostasis. In our research, revealed upregulate the S-glutathionylation level of Pik3r1 Cys498 Cys670, thereby decreasing phosphorylation,...
Gene transfection was supposed to be the most promising technology overcome vast majority of diseases and it has been popularly reported in clinical applications gene therapy. In spite rapid development novel materials methods, influence morphology-dependent nanomechanics malignant osteosarcoma on is still unsettled. this study, cell spreading adhesion area adjusted by prepared micropatterns regulate focal (FA) formation cytoskeletal organization cells. The micropattern-dependent FA...
Abstract Over‐activated osteoclastogenesis, which is initiated by inflammation, has been implicated in osteoporosis. Corilagin, a natural compound extracted from various medicinal herbaceous plants, such as Cinnamomum cassia , antioxidant and anti‐inflammatory activities. We found that Corilagin suppressed osteoclast differentiation dose‐dependent manner, significantly decreased osteoclast‐related gene expression impaired bone resorption osteoclasts. Moreover, phosphorylation of members the...
Poly-γ-l-glutamic acid (PGA) is an outstanding drug carrier candidate owning to its excellent biodegradability and biocompatibility. The PGA may shield toxic drugs from the body enable delivery of poorly soluble or unstable thereby minimize side effects improve efficacy. However, limitation as a low loading efficiency (DLE), which usually below 30%. In this study, we reported chemical modification method using l-phenylalanine ethyl ester (PAE). PGA–PAE construct was amphiphilic, could form...
cis-Dichlorodiamineplatinum (CDDP) was one of the most common used drugs in clinic for cancer treatment. However, CDDP caused a variety side effects. The abundant carboxyl groups on surface poly glutamic acid (PGA) could be modified with various kinds targeted ligands. PGA delivery system loaded therapies possesses potential to overcome effects.In this study, we constructed safe and efficient anticancer drug PGA-Asp-maleimide-cisplatin-peptide complex (PAMCP), which conjugated transferrin...