A5102161819- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Graphene and Nanomaterials Applications
- Microtubule and mitosis dynamics
- Cancer, Hypoxia, and Metabolism
- Genetics, Aging, and Longevity in Model Organisms
- Mesenchymal stem cell research
- Plant Reproductive Biology
- Acne and Rosacea Treatments and Effects
- Nanoparticles: synthesis and applications
- Pelvic floor disorders treatments
- Corneal Surgery and Treatments
- Membrane Separation Technologies
- Epigenetics and DNA Methylation
- Lanthanide and Transition Metal Complexes
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Polysaccharides and Plant Cell Walls
- Platelet Disorders and Treatments
- Cancer, Lipids, and Metabolism
- Congenital heart defects research
- Angiogenesis and VEGF in Cancer
- Pancreatic function and diabetes
- Herpesvirus Infections and Treatments
- Renal Diseases and Glomerulopathies
First Affiliated Hospital of Jinan University
2022-2025
Zhengzhou University
2024
Lanzhou University
2019-2021
Beijing Institute of Education
2021
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2021
Shenyang Pharmaceutical University
2021
Academy of Military Medical Sciences
2017-2019
The Affiliated Yongchuan Hospital of Chongqing Medical University
2017
Chongqing Medical University
2017
Binzhou Medical University
2011-2014
After myocardial infarction (MI), the scar tissue contributes to ventricular dysfunction by electrically uncoupling viable cardiomyocytes in infarct region. Injection of a conductive hydrogel could not only provide mechanical support infarcted region, but also synchronize contraction and restore function connecting isolated intact tissue. Methods: We created introducing graphene oxide (GO) nanoparticles into oligo(poly(ethylene glycol) fumarate) (OPF) hydrogels. The hydrogels were...
Abstract Formins have long been known to regulate microfilaments but also recently shown associate with microtubules. In this study, Arabidopsis thaliana FORMIN14 (AFH14), a type II formin, was found both microtubule and microfilament arrays. AFH14 expressed in BY-2 cells decorate preprophase bands, spindles, phragmoplasts induce coalignment of microtubules microfilaments. These effects perturbed the process cell division. Localization microtubule-based structures confirmed suspension cells....
Gene families expand by gene duplication, and resulting paralogs diverge through mutation. Functional diversification can include neofunctionalization as well subfunctionalization of ancestral functions. In addition, redundancy in which multiple genes fulfill overlapping functions is often maintained. Here, we use the family 40 Caenorhabditis elegans insulins to gain insight into balance between specificity redundancy. The insulin/insulin-like growth factor (IIS) pathway comprises a single...
Qianliexin capsule (QLX) is a standardized traditional Chinese herbal preparation that has long been used to treat chronic non-bacterial prostatitis (CNP) and benign prostatic hyperplasia (BPH). This study investigated the anti-inflammatory activity of QLX in improving lower urinary tract symptoms (LUTS) associated with CNP BPH. Rat models BPH were induced by oestradiol or testosterone (hormonal imbalance) chemical inflammation (carrageenan). significantly relieved LUTS rat model reducing...
Intrauterine adhesion (IUA) caused by endometrial injury is the most common cause of female uterine infertility. Current treatments offer limited clinical benefits. In this study, we investigated role human umbilical cord mesenchymal stem cells (hUCMSCs) loaded collagen scaffold in regeneration injured endometrium an IUA rat model. Following construction model mechanical injury, scaffold, hUCMSCs, or hUCMSCs-loaded was transplanted. The implantation significantly increased thickness...
<title>Abstract</title> <bold>Background </bold>The licensed adjuvanted recombinant glycoprotein E (gE) subunit vaccine (HZ/su) is highly efficient against herpes zoster (HZ). We compared the immunogenicity and safety of a novel gE-Fc fusion protein candidate (LZ901) with HZ/su. <bold>Methods</bold> This was randomised, active-controlled, non-inferiority trial conducted in Wuxi, China, involving healthy adults aged 50 years older who had not previously received HZ vaccine. Eligible...
Purpose: This study investigated the anti-tumour effects of novel vascular disrupting agent plinabulin (NPI-2358) when given alone or combined with radiation.Materials and methods: Foot implanted C3H mammary carcinomas leg KHT sarcomas were used, injected intraperitoneally. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) measurements made gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) on a 7-tesla magnet. Treatment response was assessed using regrowth delay (C3H...
The use of engineered cardiac tissues (ECTs) is a new strategy for the repair and replacement in patients with myocardial infarction, particularly at late stages.
Casein kinase 2-interacting protein-1 (CKIP-1) is a known regulator of cardiomyocytes and macrophage proliferation. In this study, we showed that CKIP-1 was involved in the process megakaryocytic differentiation. During differentiation K562 cells, dramatically upregulated upregulation induced by PMA mediated through downregulation transcription factor GATA-1. By transient transfection, oligonucleotide-directed mutagenesis chromatin immunoprecipitation assays, identified transcriptional...
Whole organ or tissue decellularized matrices are a promising scaffold for engineering because they maintain the specific memory of original tissue.
We recently reported that AFH14 participated in microtubule and actin filament interaction cell division, the (FH1FH2) was important to directly binding activity of microtubules microfilaments. To preliminarily understand function localization non-dividing cells, we overexpressed FH1FH2-RFP onion epidermal found a fluorescence labeled filamentous network. The result double labeling with different cytoskeleton reporter proteins indicated co-localized cortical microtubules. Treatment cells...
Abstract The centrosome serves as the main microtubule-organizing structure, playing crucial roles in animal development. Uncovering new components and elucidating their functions helps to understand regulation of cell maintenance division by centrosome. In this study, through a combination genetic analyses biological characterizations, we identify IQ Motif Containing G (IQCG) novel microtubule nucleation factor with dual role involved both centrosomal organization mitotic spindle formation....
Abstract Background: We have previously developed a prevascularized platform by seeding endothelial cells on the mesenchymal stem cell sheet and technology provides promising vascularization potential for wide applications in tissue engineering. However, mechanism behind interactions between sheet-derived matrix (ECs) are still unknown. The purpose of this study is to investigate role MMPs angiogenesis process vitro . Methods: Human bone marrow-derived (hBMSCs) were cultured continually form...
The effect of vascular disrupting agents in tumour therapy depends on both the immediate shutdown, and following re-vascularization tumour. aim this study was to use a model investigate whether endothelial outgrowth cells (EOCs) influenced short term treatment efficiency combretastatin A-4 disodium phosphate (CA4P) 5,6-dimethylxanthenone-4-acetic acid (DMXAA) by increasing EOC recruitment.In order visualize recruitment EOCs tumours, umbilical cord blood derived human were labelled with...