A5100768813- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Electrochemical sensors and biosensors
- SARS-CoV-2 and COVID-19 Research
- Plant Pathogenic Bacteria Studies
- Electrochemical Analysis and Applications
- Water Quality Monitoring and Analysis
- Atmospheric chemistry and aerosols
- bioluminescence and chemiluminescence research
- Immune cells in cancer
- Sulfur Compounds in Biology
- RNA Research and Splicing
- Cancer-related gene regulation
- Pluripotent Stem Cells Research
- Advanced Chemical Sensor Technologies
- MicroRNA in disease regulation
- Wnt/β-catenin signaling in development and cancer
- Viral gastroenteritis research and epidemiology
- Cancer, Hypoxia, and Metabolism
- Parasites and Host Interactions
- COVID-19 and healthcare impacts
- Grief, Bereavement, and Mental Health
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2024-2025
University of Electronic Science and Technology of China
2024-2025
Nanjing Medical University
2015-2024
Zhejiang University
2018-2024
Jiangsu Institute of Parasitic Diseases
2024
Singapore General Hospital
2022-2024
Jiangsu Cancer Hospital
2017-2024
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2020-2024
National Clinical Research Center for Digestive Diseases
2024
First Affiliated Hospital of Zhengzhou University
2024
Background Lung cancer is the deadliest form of malignancy and most common subtype non-small cell lung (NSCLC). Hypoxia a typical feature solid tumor microenvironment. In current study, we clarified effects hypoxia on stemness metastasis molecular mechanism.
Coronavirus disease 2019 (COVID-19) broke out and then became a global epidemic at the end of 2019. With increasing number deaths, early identification severity interpretation pathogenesis are very important. Aiming to identify biomarkers for progression COVID-19, 75 COVID-19 patients, 34 healthy controls 23 patients with pandemic influenza A(H1N1) were recruited in this study. Using liquid chip technology, 48 cytokines chemokines examined, among which 33 significantly elevated compared...
Gut microbiota are closely related to lipopolysaccharide (LPS)-induced acute lung injury (ALI). Akkermansia muciniphila (A. muciniphila) maintains the intestinal barrier function and regulates balance of reduced glutathione/oxidized glutathione. However, it may be useful as a treatment strategy for LPS-induced injury. Our study aimed explore whether A. could improve by affecting gut microbiota. The administration effectively attenuated tissue damage significantly decreased oxidative stress...
Lung cancer is the most common solid tumor around world. It has been reported that upregulation of long noncoding RNA (lncRNA) plasmacytoma variant translocation 1 (lncRNA-PVT1) closely associated with metastasis. However, function and underlying molecular mechanism lncRNA-PVT1 in nonsmall cell lung (NSCLC) invasion remain unknown. In this study, we found overexpression promoted invasive ability NSCLC cells, whereas silence suppressed invasion. Furthermore, upregulated MMP9 expression a...
Esophageal cancer is one of the deadliest cancers worldwide occurring at upper gastrointestinal tract. This study aimed to explore possible role long non-coding RNA X Inactive Specific Transcript (XIST) in development esophageal cancer.The lncRNA XIST expressions both tissues and cells were investigated. The TE-1 SKGT-4 transfected with LV-sh-XIST LV-scramble for further detection effects expression on cell biological processes, including proliferation, apoptosis apoptosis-related proteins,...
Understanding the immunological characteristics of monocytes-including associated with fibrosis-in severe coronavirus disease 2019 (COVID-19) is crucial for understanding pathogenic mechanism and preventing severity. In this study, we performed single-cell transcriptomic sequencing peripheral blood samples collected from six healthy controls 14 COVID-19 including severe, moderate, convalescent three severely/critically ill four moderately patients. We found that monocytes were strongly...
To determine the role of recently recognized enteropathogens in childhood diarrhea China, 221 children with and 108 controls seen at Beijing Children's Hospital were studied during April May 1989. Stools examined for ova, parasites, rotavirus, cultured bacterial pathogens, probed enterotoxigenic Escherichia coli (ETEC), enteroinvasive E. (EIEC), enterohemorrhagic (EHEC), enteropathogenic adherence factor-positive (EAF+) coli. Pathogens identified 56.5% 43.5% (P = 0.04). Detection was...
The purpose of this study was to investigate the function Zinc finger protein 488 (ZNF488) in nasopharyngeal carcinoma (NPC). endogenous expression ZNF488 NPC tissues, normal epithelium tissues and cell lines were detected by quantitative reverse transcription polymerase chain reaction. over-expressing knock-down line models established through retroviral vector pMSCV mediated over-expression small interfering RNA (siRNA) knock-down. invasion migration capacities evaluated wound healing...
Abstract Background Nasopharyngeal carcinoma (NPC) is one of the most frequent head and neck malignant tumors. Long noncoding RNAs play critical roles in tumorigenesis. Methods Real‐time quantitative PCR arrays were used to evaluate expression levels cytoskeleton regulator RNA (CYTOR) NPC tissues cells. Cell counting kit‐8 colony formation analyses test cell viability, while wound healing transwell assays employed detect invasion migration ability. Luciferase reporter assay Western blot...
The role of transforming growth factorβ (TGF-β)-induced tumor progression in advanced malignancy is well established, but the involvement long non-coding RNAs (lncRNAs) TGF-β signaling remains unclear. This study aimed to identify TGF-β-associated lncRNAs head and neck squamous cell carcinoma (HNSCC). Expression profiling was obtained using Gene Omnibus Cancer Genome Atlas. Real-time quantitative PCR used analyze expression EPB41L4A-AS2 HNSCC line. We bioinformatics resources (DAvID) conduct...
Nasopharyngeal carcinoma (NPC) is a common malignant tumor characterized by highly local invasion and distant metastasis. Recently, increasing attention has been paid to long noncoding RNAs (lncRNAs), which play significant roles in tumorigenesis progression. However, little known about the potential role of lncRNA urothelial carcinoma-associated 1 (UCA1) NPC cell migration.
Background: E2F transcription factor 3 (E2F3) is oncogenic and dysregulated in various malignancies. Complex networks involving microRNAs (miRNAs) E2F3 regulate tumorigenesis progression. However, the potential roles of its target miRNAs nasopharyngeal carcinoma (NPC) are rarely reported. Methods: expression was detected human NPC tissues cell lines through quantitative real-time PCR. proliferation, migration, invasion were evaluated vitro by colony forming, counting kit-8, wound healing,...
In this study, we propose an on-site electrochemical platform for sensitive simultaneous genotyping of the two major EGFR mutations (19del and L858R) through plasma ctDNA based on tetrahedral DNA nanostructure decorated screen-printed electrodes.
In patients with head and neck cancer (HNC), lymph node (N) metastases are associated aggressiveness poor prognosis. Identifying meaningful gene modules representative biomarkers relevant to the N stage helps predict prognosis reveal mechanisms underlying tumor progression. The present study used a step‑wise approach for weighted co‑expression network analysis (WGCNA). Dataset GSE65858 was subjected WGCNA. RNA sequencing data of HNC downloaded from Cancer Genome Atlas (TCGA) dataset GSE39366...
Since the December 2019 outbreak of coronavirus disease (COVID-19) in Wuhan, infection has spread locally and globally resulting a pandemic. As numbers confirmed diagnoses deaths continue to rise, COVID-19 become focus international public health. is highly contagious, there no effective treatment yet. New strategies are urgently needed improve success rate severe critically ill patients. Increasing evidence shown that cytokine storm plays an important role progression COVID-19. The...
Downstream sequences influence activity of the rice tungro bacilliform virus (RTBV) promoter in protoplasts derived from cultured cells. We previously identified a DNA element located between positions +50 and +90 relative to transcription start site which nuclear proteins bind. In this study, using UV crosslinking assays, we show that two bind specifically element. demonstrate enhances RTBV copy number-dependent manner when transferred position upstream promoter. addition, electrophoretic...
Central nervous system (CNS) infections caused by carbapenem-resistant Gram-negative bacteria (CR-GNB) present a major health and economic burden worldwide. This multicentre prospective study aimed to assess the feasibility usefulness of CSF therapeutic drug monitoring (TDM) after intrathecal/intraventricular administration polymyxin B in patients with CNS infections.
Long non-coding RNAs (lncRNAs) have been reported to perform significant roles in cancer development and progression. Our research has found that a novel lncRNA n326322 was higher nasopharyngeal carcinoma (NPC) cells. Moreover, the gain loss of functional approaches revealed overexpression lncRNA-n326322 promoted NPC cell proliferation invasion, whereas downregulation suppressed invasion. Further experiments demonstrated potential mechanism may be associated with activation PI3K/AKT ERK/MAPK...
The coronavirus disease 2019 (COVID-19) pandemic has caused significant psychological distress globally. Our study assessed the prevalence of and associated factors during COVID-19 among kidney transplant recipients donors.
Background: Long noncoding RNAs (lncRNAs) are known as key regulators in many cancer types, but their biological functions nasopharyngeal carcinoma (NPC) remain largely unknown. In the present study, we aim to explore role of lncRNA ZNRD1-AS1 NPC tumor development. Methods: The tissues and cells was explored by using quantitative real-time PCR assay. Cellular behavioral experiments were used testing cell proliferation, invasion, migration. Luciferase reporter assay, RNA-binding protein...
Abstract A rapid, simple and sensitive fluorimetric method has been developed for the determination of atmospheric sulphur dioxide with dichlorofluorescein as fluorogenic reagent (λex = 505 nm, λem 520 nm) at pH 4.0–6.0. linear calibration curve was obtained in range 0.01–0.40 μg SO2/25 ml. The detection limit is 0.01 Nitrogen does not interfere method. successfully applied to dioxide. ∗Supported by National Science Foundation Gansu, China. Key Words: Fluorimetric methodsulphur dioxide2′,...