A5036122250- Renal Transplantation Outcomes and Treatments
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Organ Donation and Transplantation
- COVID-19 Impact on Reproduction
- Organ Transplantation Techniques and Outcomes
- Long-Term Effects of COVID-19
- Hepatitis C virus research
- Transplantation: Methods and Outcomes
- COVID-19 and healthcare impacts
- Mosquito-borne diseases and control
- Cytomegalovirus and herpesvirus research
- Cardiac Valve Diseases and Treatments
- Neurological Complications and Syndromes
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Organ and Tissue Transplantation Research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Renal Diseases and Glomerulopathies
- Renal and Vascular Pathologies
- Cardiovascular Issues in Pregnancy
- Vaccine Coverage and Hesitancy
- Palliative Care and End-of-Life Issues
- Animal Virus Infections Studies
- Viral Infections and Immunology Research
Singapore General Hospital
2016-2025
SingHealth Duke-NUS Academic Medical Centre
2020-2025
SingHealth
2020-2023
Duke-NUS Medical School
2018-2023
National University of Singapore
2022
University of British Columbia
2015
Treatment decisions in kidney transplantation requires patients and clinicians to weigh the benefits harms of a broad range medical surgical interventions, but heterogeneity lack patient-relevant outcomes across trials makes these trade-offs uncertain, thus, need for core outcome set that reflects stakeholder priorities.We convened 2 international Standardized Outcomes Nephrology-Kidney Transplantation consensus workshops Boston (17 patients/caregivers; 52 health professionals) Hong Kong (10...
Abstract Introduction To report the progress of human living uterus transplant research project in Singapore. Material and Methods The began 2012 with a collaboration between Swedish Singapore teams. Ethics approval was obtained from SingHealth Centralised Institutional Review Board, Transplant General Hospital Biomedical Committee to perform 5 procedures collaborative multi‐site study at Hospital. Regulatory Ministry Health, A suitable recipient–donor pair identified. donor perimenopausal...
Background Identification of risk factors for BK polyoma virus (BKPyV) without confounding by donor and era effects in paired analysis may inform strategies to prevent BKPyV. Methods In this 21,575 mate kidney pairs the Scientific Registry Transplant Recipients between 2004 2010, presence a treatment code BKPyV follow-up forms was used identify which 1 2 kidneys treated (discordant treatment) or both were (concordant treatment). Results Among 1975 discordant pairs, younger than 18 years 60...
Cherie Le Si Gan, Shimin Jasmine Chung, Quan Yao Ho, Thuan Tong Tan, Ban Hock Ian Tatt Liew, Carolyn Shan-Yeu Tien, Sobhana Thangaraju, Terence Kee. Clin Transplant Res -0001;0:. https://doi.org/10.4285/ctr.24.0045
There had been numerous efforts worldwide to identify the issues pertaining gender disparity in kidney transplantation.1 Globally, reports on inequity access transplantation have shown that adult women with failure are less likely receive dialysis than men.2,3 Among patients treated dialysis, be listed for and once waiting list, they also transplanted.4 Despite technological advances innovations medicine surgery, such as improved tissue typing surgical techniques, disparities persistent,...
Dengue virus (DENV), a mosquito-borne pathogen, causes systemic infections. There are no clear guidelines regarding the screening of donor blood is used in endemic countries to prevent transfusion or transplant-associated dengue. DENV has been shown be detected urine samples even when viremia undetectable. We describe an incident dengue where tested negative for but positive viuria resulting transmission our two kidney recipients. Both recipients resolved infection uneventfully, with adverse...
A successful vaccination programme forms the cornerstone of controlling coronavirus disease 2019 (COVID-19). The unprecedented speed COVID-19 vaccine development and lack long-term data have raised fears regarding its safety efficacy. Vaccine hesitancy can undermine uptake, hence success programme. Given high complication rates infections in kidney transplant recipients, it is particularly important to identify address this population.We conducted a cross-sectional survey among recipients...
INTRODUCTIONTo study the prevalence of hepatitis C virus (HCV) infection in blood donor (BD), haemodialysis (HD) and intravenous drug user (IVDU) populations Singapore assess IL28B polymorphism if HCV positive. METHODSThe BD population were healthy volunteers, HD patients who on for at least six months follow-up between January 2009 December 2014.IVDU was from inmates halfway houses consented. RESULTSBetween 2011 2014, 161,658 individuals underwent screening prior to donation, 95 (0.059%)...
Introduction: Coronavirus Disease 2019 (COVID-19) has significantly affected the way healthcare is delivered in Singapore. Healthcare services such as renal transplantation had to rapidly adjust and meet needs (1) protect patients staff, (2) ramp up, conserve or redeploy resources while (3) ensuring that critical remained operational. This paper aims describe experience of transplant programme at Singapore General Hospital (SGH) responding risks constraints posed by pandemic. Methods...
The coronavirus disease 2019 (COVID-19) pandemic has caused significant psychological distress globally. Our study assessed the prevalence of and associated factors during COVID-19 among kidney transplant recipients donors.
Double-filtration plasmapheresis (DFPP) has been utilized for immunomodulation in kidney transplantation. Anticoagulation is important to maintain circuit patency during DFPP. We aimed compare the efficacy and safety of regional citrate anticoagulation (RCA) with systemic heparin DFPP transplant recipients.A retrospective cohort study was conducted RCA (RCA-DFPP) (Hep-DFPP) among recipients a single tertiary center.A total 112 sessions were performed 23 subjects, which 62 RCA-DFPP 50...
The COVID-19 pandemic is protracted and episodic surges from viral variants continue to place significant strain on healthcare systems. vaccines, antiviral therapy monoclonal antibodies have significantly reduced associated morbidity mortality. Concurrently, telemedicine has gained acceptance as a model of care tool for remote monitoring. These advances allow us safely transit our inpatient-based infected kidney transplant recipients (KTRs) hospital-at-home (HaH) care.KTRs with PCR-proven...
Introduction: Percutaneous renal biopsy remains critical for the workup of allograft dysfunction but is associated with risk bleeding. Prophylactic intravenous desmopressin has been proposed to reduce bleeding in native biopsies, its efficacy transplant population unclear and adverse events such as severe hyponatraemia have reported. Materials Methods: We conducted a single-centre retrospective cohort study involving adult (≥21 years old) recipients impaired function (serum creatinine ≥150...
Early diagnosis remains key for effective prevention and treatment. Unfortunately, current screening with anti-hepatitis C virus antibody (anti-HCV Ab) test may have limited utility in the of HCV infection reinfection. This is special concern to at-risk population, such as immunocompromised hosts end-stage renal failure patients on hemodialysis. antigen (Ag) could be useful identifying ongoing clinical scenarios. Hence, we aimed study Ag testing acute chronic hepatitis C. Of 89 samples...
Cardiac evaluation before deceased donor kidney transplant (DDKT) remains a matter of debate. Data on Asian countries and with prolonged waiting times are lacking. This study aimed to assess the outcomes patients referred for DDKT after cardiac at an tertiary center.This single-center retrospective review analyzed who were waitlist placement underwent stress testing between January 2009 December 2015. Patients symptoms excluded. The primary outcome was three-point major adverse...
Abstract Background and Aims Valvular heart disease (VHD) is a risk factor for adverse outcomes in end-stage kidney (ESKD) patients. However, the impact of individual valvular lesions on patients transplant waitlist unclear. This study aims to analyse relationship between different VHD all-cause mortality, determine characteristics stratified by types VHD. Method was single-center retrospective cohort ESKD who were referred placement from May 2008 February 2021 had undergone baseline...