A5067946262- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Chromatin Remodeling and Cancer
- RNA Research and Splicing
- Acute Myeloid Leukemia Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- interferon and immune responses
- Signaling Pathways in Disease
- Plant Pathogens and Fungal Diseases
- Pluripotent Stem Cells Research
- Transplantation: Methods and Outcomes
- Postharvest Quality and Shelf Life Management
- Blood disorders and treatments
- FOXO transcription factor regulation
- Chronic Myeloid Leukemia Treatments
- Erythrocyte Function and Pathophysiology
- Plant-Microbe Interactions and Immunity
- Endoplasmic Reticulum Stress and Disease
- Autophagy in Disease and Therapy
- Cellular transport and secretion
- Mycorrhizal Fungi and Plant Interactions
- Aluminum Alloy Microstructure Properties
- Genomics and Chromatin Dynamics
Ludwig-Maximilians-Universität München
2016-2023
Jiangsu Cancer Hospital
2017-2021
Nanjing Medical University
2017-2021
State Forestry and Grassland Administration
2020
Nanjing University
2017-2019
Laboratoire de Biologie Cellulaire et Moléculaire du Contrôle de la Prolifération
2012
Beijing Normal University
2012
The relevance of molecular mechanisms governing mitochondrial proteostasis to the differentiation and function hematopoietic immune cells is largely elusive. Through dissection network proteins related HCLS1-associated protein X-1, we defined a potentially novel functional CLPB/HAX1/(PRKD2)/HSP27 axis with critical importance for neutrophil granulocytes and, thus, elucidated metabolic underlying congenital neutropenia in patients HAX1 deficiency as well bi- monoallelic mutations CLPB. As...
Mitoribosome in mammalian cells is responsible for synthesis of 13 mtDNA-encoded proteins, which are integral parts four mitochondrial respiratory chain complexes (I, III, IV and V). ERAL1 a nuclear-encoded GTPase important the formation 28S small mitoribosomal subunit. Here, we demonstrate that knockdown by RNA interference inhibits protein promotes reactive oxygen species (ROS) generation, leading to autophagic vacuolization HeLa cells. Cells lack expression showed significant conversion...
Circular RNA (circRNA) exhibits a covalently closed circular conformation and is structurally stable. Nevertheless, the precise effects exerted by circRNA in esophageal squamous cell carcinoma (ESCC) remains uncertain. was ascertained human array study confirmed quantification of reverse transcriptase polymerase reactions. A luciferase reporter, fluorescence situ hybridization experiment exploited to explore interaction between circ-ZDHHC5 miR-217. The function determined siRNA-mediated...
Abstract Clathrin-mediated endocytosis (CME) is critical for internalisation of molecules across cell membranes. The FCH domain only 1 (FCHO1) protein key molecule involved in the early stages CME formation. consequences mutations FCHO1 humans were unknown. We identify ten unrelated patients with variable T and B lymphopenia, who are homozygous six distinct . demonstrate that these either lead to mislocalisation or prevent its interaction binding partners. Live-cell imaging cells expressing...
Objective To illustrate the role of FOXF2 in aggravation progression non-small cell lung cancer (NSCLC) by targeting long non-coding RNA (lncRNA) H19 to down-regulate gene phosphate and tensin homolog deleted on chromosome ten (PTEN). Patients methods The relative levels NSCLC tissues adjacent normal were detected quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). correlation between expression was analyzed. Kaplan-Meier curves depicted for uncovering prognostic value patients....
Nasopharyngeal carcinoma (NPC) is known for its potential to progress the lymph nodes and distant metastases at an early stage.As important regulator in tumorigenesis biological processes, functions of lncRNA NPC tumor development remain largely unclear.In this research, expression EPB41L4A-AS2 tissues cells was analyzed via real-time quantitative polymerase chain reaction (qRT-PCR).CCK8, colony formation, EDU experiments were used determine viability cells.Transwell wound healing assays...
Nasopharyngeal carcinoma (NPC) is a common malignant tumor characterized by highly local invasion and distant metastasis. Recently, increasing attention has been paid to long noncoding RNAs (lncRNAs), which play significant roles in tumorigenesis progression. However, little known about the potential role of lncRNA urothelial carcinoma-associated 1 (UCA1) NPC cell migration.
MicroRNAs (miRNAs) have been reported to regulate the expression of genes by suppressing translation or facilitating mRNA decay. Their regulates a wide variety cellular processes, including development and progression cancer. Esophageal squamous cell carcinoma (ESCC) is malignant cancer with high morbidity recurrence in Asia. In present study, biological function miR-125b its underlying mechanism ESCC were explored. The results revealed that was significantly decreased tissues lines. A...
Abstract Huperzine A (HupA), derived from Huperzia Serrata , has exhibited a variety of biological actions, in particular neuroprotective effect. However, the protective activities HupA on murine embryonic fibroblast NIH3T3 cells after X‐rays radiation have not been fully elucidated. Herein, treatment dramatically promoted cell viability, abated G0/G1 peak accumulation, and ameliorated increase apoptosis radiation. Simultaneously, notably enhanced anti‐oxidant enzymes, inhibited activity...
It has been demonstrated that microRNAs (miRNAs) serve important roles in various biological processes, such as tumorigenesis. In the present study, role of miR‑30a‑3p pathogenesis esophageal carcinoma (EC) was investigated. Reverse transcription‑quantitative polymerase chain reaction performed to determine levels expression EC tissues and cell lines. Then, effects on migration, invasion radiosensitivity cells were investigated using scratch‑wound, Transwell assays, respectively. A...
Mitochondrial metabolism is critical in hematopoietic stem cell maintenance and differentiation. Here, we present a step-by-step protocol to efficiently differentiate human induced pluripotent cells into myeloid progenitors by robust feeder- serum-free system. Furthermore, provide subsequently assess mitochondrial function iPSC-derived progenitors. We comprehensively describe analyze quantify key parameters of respiration the Seahorse XFe96 Analyzer. Additionally, our includes extensive...
Abstract Resistance to conventional chemotherapy remains a huge challenge in the clinical management and treatment of hepatoblastoma, most common liver tumor childhood. The silico repurposing drugs with known pharmacokinetics safety profiles, which have been approved for other indications, represents promising strategy identify new effective chemoresistant hepatoblastoma. In this study, we integrated RNA sequencing-derived gene expression data into pharmacologic perturbation prediction tool...