A5079821679- CRISPR and Genetic Engineering
- Acute Myeloid Leukemia Research
- Regulation of Appetite and Obesity
- CAR-T cell therapy research
- Advanced biosensing and bioanalysis techniques
- Immunodeficiency and Autoimmune Disorders
- Multiple Sclerosis Research Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Chromatin Remodeling and Cancer
- Liver Disease Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Herpesvirus Infections and Treatments
- Dietary Effects on Health
- NF-κB Signaling Pathways
- Biosimilars and Bioanalytical Methods
- Neuroblastoma Research and Treatments
- Liver Disease and Transplantation
- melanin and skin pigmentation
- Drug-Induced Adverse Reactions
- Pluripotent Stem Cells Research
- Inflammasome and immune disorders
- Cancer therapeutics and mechanisms
- Infant Nutrition and Health
- Single-cell and spatial transcriptomics
- Myeloproliferative Neoplasms: Diagnosis and Treatment
Boehringer Ingelheim (Germany)
2023-2024
Helmholtz Zentrum München
2019-2023
Urmia University of Medical Sciences
2023
Islamic Azad University, Science and Research Branch
2023
Urmia University
2023
Center for Environmental Health
2022
Shahid Beheshti University
2019
Ludwig-Maximilians-Universität München
2014-2018
Isfahan University of Medical Sciences
2014
University of Isfahan
2011-2014
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is a critical regulator of cell death and inflammation, but its relevance for human disease pathogenesis remains elusive. Studies monogenic disorders might provide insights into mechanisms therapeutic targeting RIPK1 common diseases. Here, we report on eight patients from six unrelated pedigrees with biallelic loss-of-function mutations in presenting primary immunodeficiency and/or intestinal inflammation. Mutations were...
Chronic liver diseases, such as non-alcoholic steatohepatitis (NASH)-induced cirrhosis, are characterized by an increasing accumulation of stressed, damaged, or dying hepatocytes. Hepatocyte damage triggers the activation resident immune cells, Kupffer cells (KC), well recruitment from circulation toward areas inflammation. After infiltration, monocytes differentiate into monocyte-derived macrophages (MoMF) which functionally distinct KC. We herein aim to compare in vitro signatures...
Acute leukemias represent deadly malignancies that require better treatment. As a challenge, treatment is counteracted by microenvironment protecting dormant leukemia stem cells.To identify responsible surface proteins, we performed deep proteome profiling on minute numbers of patient-derived xenograft (PDX) cells isolated from mice. Candidates were functionally screened establishing comprehensive CRISPR‒Cas9 pipeline in PDX models vivo.A disintegrin and metalloproteinase domain-containing...
Abstract Resistance towards cancer treatment represents a major clinical obstacle, preventing cure of patients. To gain mechanistic insights, we developed model for acquired resistance to chemotherapy by treating mice carrying patient derived xenografts (PDX) acute lymphoblastic leukemia with widely-used cytotoxic drugs 18 consecutive weeks. In two distinct PDX samples, tumors initially responded treatment, until stable disease and eventually tumor re-growth evolved under therapy, at highly...
Abstract Objectives A growing body of evidence shows that leptin acts as a pro‐inflammatory cytokine in autoimmune disorders and is related to multiple sclerosis ( MS ) pathogenesis. The present study was an analysis serum levels among healthy volunteers patients with different subtypes , opticospinal OSMS neuromyelitis optica NMO ). Methods Leptin concentrations the sera 121 201 well 27 were measured. Results Significant differences observed between volunteers, P < 0.001). Furthermore,...
Immune dysregulation and inflammation by hepatic-resident leukocytes is considered a key step in disease progression of non-alcoholic fatty liver steatohepatitis toward cirrhosis hepatocellular carcinoma. Here, we provide protocol for isolation characterization liver-resident immune cells from fine-needle biopsies obtained rodent model humans. We describe steps isolating leukocytes, cell sorting, RNA extraction sequencing. then detail procedures low-input mRNA sequencing analyses.
Adverse drug reactions (ADR) are considered any harmful and unintended side effects associated with the use of a at usual therapeutic dose, in which skin is involved most cases. Therefore, availability epidemiological information on reactions, reaction patterns, their causative drugs can be helpful timely diagnosis necessary measures, such as caution prescribing to prevent these types reactions.In this retrospective descriptive study, archived files patients dermatoses due ADR referred...
Abstract Background: Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the CNS resulting in accumulating neurological disability. Recent evidences have strongly indicated that leptin has influence on immune system and maybe involved pathogenesis autoimmune diseases such as MS. Objectives: To compare serum levels among healthy volunteers patients with different subtypes MS to investigate its association progression. Material Methods: Leptin concentrations sera 114 136...
Objectives: Sibling relationships are often among the long-lasting and more than two-thirds of adolescents with siblings introduce their as most important people in life. Therefore, this study aims to evaluate effectiveness communication skills on sibling Down syndrome. Methods: This is a quasi-experimental based pre-test-post-test design control group. A total 60 were members Iranian association for syndrome Tehran City, Iran. From population, 30 selected inclusion exclusion criteria...
In this paper, we propose a new parametric distribution which called as the Beta Modified Weibull Power Series (BMWPS) distribution. This is obtained by compounding (BMW) and power series distributions. BMWPS contains, special sub-models, such Poisson (BMWP) distribution, Geometric (BMWG) Logarithmic (BMWL)
Background: Tumor-microenvironment interactions are critically important determinants contributing to leukemia formation and maintenance. Interrupting the leukemia-bone marrow interaction represents an attractive therapeutic approach in acute (AL). Functional genomics significantly increases our understanding of vulnerabilities gene dependencies individual tumors. Aims: Here, we developed a CRISPR-Cas9 screening for functional analysis surface molecules patient-derived xenograft (PDX) AL...