A5102800804- Acute Lymphoblastic Leukemia research
- Ubiquitin and proteasome pathways
- Protein Degradation and Inhibitors
- Cancer Genomics and Diagnostics
- Cell death mechanisms and regulation
- Histone Deacetylase Inhibitors Research
- Cancer-related Molecular Pathways
- FOXO transcription factor regulation
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Heat shock proteins research
- Biochemical and Molecular Research
- thermodynamics and calorimetric analyses
- Polyamine Metabolism and Applications
- Microtubule and mitosis dynamics
- Amino Acid Enzymes and Metabolism
- Glioma Diagnosis and Treatment
- Metabolomics and Mass Spectrometry Studies
- Circular RNAs in diseases
- Cancer Mechanisms and Therapy
- Evolution and Genetic Dynamics
- Angiogenesis and VEGF in Cancer
- 3D Printing in Biomedical Research
- Bioinformatics and Genomic Networks
- Chromatin Remodeling and Cancer
Ludwig-Maximilians-Universität München
2021-2024
LMU Klinikum
2024
Universität Ulm
2016-2021
Istanbul Technical University
2015-2019
University Medical Center
2016
Background: As the variable clinical outcome of patients with hepatoblastoma (HB) cannot be explained by genetics alone, identification drugs potential to effectively reverse epigenetic alterations is a promising approach overcome poor therapy response. The gene ubiquitin like PHD and ring finger domains 1 (UHRF1) represents an encouraging target due its regulatory function in both DNA methylation histone modifications relevance HB. Methods: Patient-derived xenograft vitro vivo models were...
Alterations of the tumor suppressor gene TP53 are found in different cancers, particular carcinomas adults. In pediatric acute lymphoblastic leukemia (ALL), mutations infrequent but enriched at relapse. As most mainly DNA-binding domain missense found, resulting accumulation mutant p53, poor therapy response, and inferior outcome. Different strategies to target p53 have been developed including reactivation p53's wildtype function by small molecule APR-246. We investigated cell lines 62...
Abstract Deregulated cell death pathways contribute to leukemogenesis and treatment failure in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Intrinsic apoptosis signaling is regulated by different proapoptotic antiapoptotic molecules: BCL-2 homology domain 3 (BH3) proteins activate prodeath molecules leading cellular death, while including lymphoma 2 (BCL-2) prevent activation of counter-regulate induction. Inhibition these regulators has become a promising strategy for anticancer...
Abstract Background Patients with metastatic hepatoblastoma are treated severely toxic first-line chemotherapies in combination surgery. Yet, inadequate response of lung metastases to neo-adjuvant chemotherapy still compromises patient outcomes making new treatment strategies, tailored more efficient clearance, mandatory. Methods We harnessed a comprehensive patient-derived xenograft platform and variety vitro vivo assays establish the preclinical biological rationale for drug patients...
Bag-1 (Bcl-2-associated athanogene) is a multifunctional anti-apoptotic protein frequently overexpressed in cancer. interacts with variety of cellular targets including Hsp70/Hsc70 chaperones, Bcl-2, nuclear hormone receptors, Akt and Raf kinases. In this study, we investigated detail the effects on major cell survival pathways associated breast cancer.Using immunoblot analysis, examined expression profiles tumor normal tissues cancer patients different receptor status. We proliferation,...
Abstract SMAC-mimetics represent a targeted therapy approach to overcome apoptosis resistance in many tumors. Here, we investigated the efficacy of SMAC-mimetic BV6 B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In ALL cell lines, intrinsic sensitivity was associated with rapid cIAP degradation, NF- κ B activation, TNF- α secretion and induction an autocrine -dependent death loop. This pattern responsiveness also observed upon ex vivo analysis 40 primograft BCP-ALL samples....
Bag‐1, Bcl‐2 associated athanogene‐1, is a multifunctional protein that can regulate wide variety of cellular processes: proliferation, cell survival, transcription, apoptosis and motility. Bag‐1 interacts with various targets in the modulation these pathways; yet molecular details Bag‐1's involvement each event are still unclear. We first showed forced expression promotes survival prevents drug‐induced MCF‐7 breast cancer cells. Increased mRNA expressions c‐myc protooncogene ornithine...
Rhabdoid tumors (RT) are among the most aggressive in early childhood. Overall survival remains poor, and treatment only effectively occurs at cost of high toxicity late adverse effects. It has been reported that neurokinin-1 receptor/ substance P complex plays an important role cancer proved to be a promising target. However, its RT not yet described. This study aims determine whether receptor is expressed (NK1R) antagonists can serve as novel therapeutic approach treating RTs. By silico...
Hepatoblastoma (HB) is the predominant form of pediatric liver cancer, though it remains exceptionally rare. While treatment outcomes for children with HB have improved, patients advanced tumors face limited therapeutic choices. Additionally, survivors often suffer from long-term adverse effects due to treatment, including ototoxicity, cardiotoxicity, delayed growth, and secondary tumors. Consequently, there a pressing need identify new effective strategies HB. Computational methods predict...
The building industry uses numerous engineering standards, codes, specifications, and regulations (henceforth, all are referred to as “regulations” for the purposes of brevity), a diverse set vocabularies describe, assess, deliver constructed facilities. These available hardcopy searchable digital documents. Some design software applications (e.g., building-energy analysis fire-egress assessment) that include computer-interpretable representations logic rules from relevant regulations. As...
Resistance to conventional chemotherapy remains a huge challenge in the clinical management of hepatoblastoma, most common liver tumor childhood. By integrating gene expression data hepatoblastoma patients into perturbation prediction tool Connectivity Map, we identified widely used anthelmintic mebendazole as drug circumvent chemoresistance permanent and patient-derived xenograft cell lines that are resistant cisplatin, therapeutic backbone treatment. Viability assays clearly indicated...
Abstract Hepatoblastoma is the most common pediatric liver tumor, and treatment of patients with preoperative chemotherapy surgical resection tumor has led to survival rates up 83%. However, resistance primary towards persistence metastases still represents major challenges achieve complete remission in high-risk patients, which associated poor prognosis. In order identify new options, we have used a newly developed vitro drug-testing platform comprised conventional cell lines cultures from...
Introduction: The tumor suppressor p53 is a key regulator of cell cycle and apoptosis in cancer. small molecule RITA interferes with MDM 2-p53 interaction resulting accumulation death induction.
Introduction: Acute lymphoblastic leukemia (ALL) cells can evade from apoptosis by upregulating anti-apoptotic proteins. Mcl-1 and Bcl-2 are frequently overexpressed in ALL, thus, appearing as promising targets for anti-ALL therapy.
Introduction: Emerging technologies such as three-dimensional (3D) cell culture and the generation of biological matrices offer exciting new possibilities in disease modelling tumour therapy. The paucity laboratory models for hepatoblastoma (HB), most prevalent malignant liver children, has hampered identification treatment options HB patients. We aimed to establish a reliable 3D testing platform using liver-derived scaffolds lines that reflect heterogeneous biology so allow reproducible...
Abstract Acute lymphoblastic leukemia (ALL) is the most common malignancy of childhood. Relapse associated with poor prognosis, requiring further investigation on high-risk leukemias. MicroRNAs (miRNAs) are involved in regulation physiological processes. Deregulated miRNAs have been described to play a role initiation and progression leukemia. Here, we investigated miRNA expression profiles comparing samples patients good outcome, also characterized by slow or rapid engraftment,...
Abstract Resistance to conventional chemotherapy remains a huge challenge in the clinical management and treatment of hepatoblastoma, most common liver tumor childhood. The silico repurposing drugs with known pharmacokinetics safety profiles, which have been approved for other indications, represents promising strategy identify new effective chemoresistant hepatoblastoma. In this study, we integrated RNA sequencing-derived gene expression data into pharmacologic perturbation prediction tool...