A5045014225- Orthopedic Infections and Treatments
- Orthopaedic implants and arthroplasty
- Bone fractures and treatments
- Animal health and immunology
- Veterinary Orthopedics and Neurology
- Surgical site infection prevention
- Hip disorders and treatments
- Veterinary Equine Medical Research
- Spine and Intervertebral Disc Pathology
- Agriculture and Farm Safety
- Intestinal and Peritoneal Adhesions
- Dental Implant Techniques and Outcomes
- Intestinal Malrotation and Obstruction Disorders
- Congenital Anomalies and Fetal Surgery
- Surgical Sutures and Adhesives
- Cervical and Thoracic Myelopathy
- Animal Behavior and Welfare Studies
- Oral and Maxillofacial Pathology
- Microbial infections and disease research
- Bone Tissue Engineering Materials
- Musculoskeletal pain and rehabilitation
- Bone Tumor Diagnosis and Treatments
- Infectious Diseases and Tuberculosis
- Musculoskeletal synovial abnormalities and treatments
- Brucella: diagnosis, epidemiology, treatment
Ludwig-Maximilians-Universität München
2010-2023
AO Foundation
2014-2022
University of Zurich
1994-2021
Innsbruck Medical University
2016
Antibiotic-loaded biomaterials (ALBs) have emerged as a potentially useful adjunctive antimicrobial measure for the prevention of infection in open fracture care.A biodegradable thermo-responsive poly(Nisopropylacrylamide) grafted hyaluronic acid (HApN) hydrogel loaded with gentamicin has recently been shown to prevent implant-related rabbit osteosynthesis model.The primary aim this study was determine influence HApN on bone healing at an early stage (4 weeks).A humeral osteotomy model...
Implantable orthopedic devices have had an enormously positive impact on human health; however, despite best practice, patients are prone to developing device-related infections (ODRI) that high treatment failure rates. One barrier the development of improved options is lack animal model may serve as a robust preclinical assessment efficacy. We present clinically relevant large chronic methicillin-resistant Staphylococcus aureus (MRSA) ODRI persists current clinical practice in medical and...
Abstract Tissue engineering repair of annulus fibrosus (AF) defects has the potential to prevent disability and pain from intervertebral disc (IVD) herniation its progression degeneration. Clinical translation AF methods requires assessment in long‐term large animal models. An ovine injury model was developed using cervical spinal levels a biopsy‐type defect assess composite tissue 1‐month 12‐month studies. The used fibrin hydrogel crosslinked with genipin (FibGen) seal defects,...
Abstract Background Patients with metastatic hepatoblastoma are treated severely toxic first-line chemotherapies in combination surgery. Yet, inadequate response of lung metastases to neo-adjuvant chemotherapy still compromises patient outcomes making new treatment strategies, tailored more efficient clearance, mandatory. Methods We harnessed a comprehensive patient-derived xenograft platform and variety vitro vivo assays establish the preclinical biological rationale for drug patients...
Antibiotic-loaded biomaterials (ALBs) have emerged as a potential useful adjunctive antimicrobial measure for the prevention of infection in open fracture care. A biodegradable thermo-responsive poly(N-isopropylacrylamide) grafted hyaluronic acid (HApN) hydrogel loaded with gentamicin has recently been shown to prevent implant-related rabbit osteosynthesis model. The primary aim this study was determine influence HApN on bone healing at an early stage (4 weeks). humeral osteotomy model...
Local antibiotic therapy is increasingly being recognised for its role in preventing and treating orthopaedic device-related infection (ODRI). A bioresorbable, injectable gentamicin-loaded hydrogel has been developed to deliver local antibiotics at the time of surgery with potential both prevention treatment ODRI. In a prophylaxis model, was compared systemic perioperative alone twelve sheep (six per group) intramedullary (IM) nail insertion tibia, which inoculated methicillin-sensitive...
Objective To explore if chemokine (C-C motif) ligand 5 (CCL5) delivery could recruit annulus fibrosus (AF) cells to the injury sites and facilitate repair of ruptured AF. Design The effects CCL5 on bovine AF in vitro were tested by transwell assay quantitative real-time polymerase chain reaction. Fibrin gel containing was used treat annulotomized caudal discs cultured under dynamic loading conditions. After 14 days loading, samples collected for histological examination. A pilot animal study...
Superconductivity at 33 K in Sr2VO3FeAs is completely suppressed by small amounts of V-doping Sr2VO3[Fe0.93(+/-0.01)V0.07(+/-0.01)]As. The crystal structures and exact stoichiometries are determined combined neutron- x-ray powder diffraction. shown to be very sensitive Fe/V mixing, which interferes with or even suppresses superconductivity. This inhomogeneity may intrinsic explains scattered reports regarding Tc reduced superconducting phase fractions Sr2VO3FeAs. Neutron diffraction data...
The treatment of chronic orthopaedic device-associated infection (ODRI) often requires multiple surgeries and prolonged antibiotic therapy. Despite this extensive protocol, the procedure is associated with significant failure rates. Currently, no large animal model available that recapitulates a failed revision. Therefore, our aim was to establish for an ODRI in order serve as testbed future interventional strategies. Adult Swiss Alpine sheep received intramedullary nail tibia localised...
The clinical, haematological and biochemical findings, treatment outcome of 63 cows with haemorrhagic bowel syndrome are described.The general condition demeanour were moderately to severely abnormal in all the cows.Signs colic occurred 27 cows, decreased rectal temperature 46 tachycardia 44.With exception one cow, intestinal motility was or absent.Transrectal palpation revealed dilatation rumen 47 small intestine 18. Faecal output markedly reduced absent, faeces dark brown black contained...
To evaluate clinical signs, diagnosis, treatment and outcome of cattle with sinonasal cysts.Case series.Cattle (n = 15).Medical records (2004-2011) a fluid-filled mass in the nasal cavity, conchae, and/or paranasal sinuses were evaluated. Data retrieved analyzed reason presentation, diagnostic techniques, surgical treatment, complications, outcome.Common presenting signs abnormal respiratory noise, discharge, effort. Mean age affected was 21.7 months. In 9 animals, cysts identified by...
Summary The clinical, radiographical and histo-pathological findings of a chondrosarcoma in the humerus goat are discussed. An 11-year-old female Saanen was admitted for evaluation chronic, progressive left forelimb lameness. Clinical examination revealed signs pain shoulder region. Radiographs scapulohumeral joint showed large lytic lesion proximal third with cortical destruction, intralesional calcification marked periosteal reactions. Differential diagnoses included aggressive bone...
To describe a technique used for reduction and internal fixation of sacral fractures in cattle.Case series.Three heifers aged 19-32 months with deformation the tail head paralysis attributable to closed fracture S5 or S4 S5.Fractures were reduced repaired under general anesthesia. A narrow, 6-10-hole, locking compression plate (LCP) was placed on spinous processes first coccygeal (Co1) using 5.0 mm screws. Follow-up inquiries made by telephone (3/3), cows examined clinically radiographically...
The aim of this report was to describe duodenal obstruction caused by a rubber foreign body in cow.The clinical, biochemical and ultrasonographic findings five-year-old Swiss Braunvieh cow with ileus calf feeding nipple are described. main clinical signs were anorexia, ruminal tympany, decreased faecal output abomasal reflux syndrome. Ultrasonographic examination revealed reticular hyperactivity dilated duodenum. A diagnosis made the underwent right-flank laparotomy, which dilation cranial...
Abstract Background The aim of this case report was to describe the clinical findings, treatment and outcome lumbosacral discospondylitis in a calf. Case Presentation A 5.5-month-old calf presented with difficulty rising, stiff slightly ataxic gait hind limbs shortened stride. region severely painful on palpation. Radiographic examination confirmed discospondylitis. Medical stall rest instituted over six weeks. ultrasonographic follow-up examinations showed lysis endplates initially, then...
The objective of this study was to establish a technique for radiographic examination the coxofemoral joint and adjacent bony structures in standing cattle. Left (or right) 30° dorsal–right left) ventral views region cattle ( n = 10) with hind limb lameness were evaluated retrospectively. In addition, an experimental oblique laterolateral bovine skeleton at angles 15–45° carried out determine optimal position visualization hip region. 10 clinical patients, bodies ilium ischium, acetabulum...
In early October 2010, a 64 year old man presented to our hospital with chest pain, fever, and night sweats, which had been present since his return Switzerland three weeks earlier. He on holiday in Turkey from July mid-September. On further questioning he reported an episode of diarrhoea sickness associated fever shortly after returning home Switzerland. During stay eaten fresh food, including meat dairy products. Furthermore, experienced myocardial infarction undergone angiography...
Abstract Objective Sheep are used as a large animal model for intervertebral disc research. However, the ovine ventral surgical approach to cervical disc, limited descriptions exist. We, therefore, give detailed in vivo anatomical description of this sheep use regeneration and degeneration models increase reproducibility such interventions. Materials Methods Eighteen female Swiss white alpine sheep, with an age range 2 4 years, were used. A access was performed establish defined punch defect...
Laterality defects are rare in cattle and usually manifest as asplenia orpolysplenia syndrome. These syndromes may be associated with situs ambiguus,which is a dislocation of some but not all internal organs. The objective ofthis report was to describe the clinical post-mortem findings includingthe macroscopic microscopic anatomy selected organs cow withpolysplenia ambiguus. A 3.5-year-old Brown Swiss referred Department FarmAnimals, Vetsuisse Faculty, University Zurich, because poor...
A three-week-old Holstein Friesian calf and a 20-month-old Jersey heifer were referred to the Department of Farm Animals, University Zurich, because coxofemoral luxation. Both animals moderately lame on affected hind limb, which was swollen in hip region appeared be adducted shorter than contralateral normal limb. Radiographs hips confirmed craniodorsal displacement femur. In both animals, traction open reduction carried out under general anaesthesia. The joint capsule, severely torn,...
ABSTRACT Standardized and reproducible animal models are required for the assessment of bone healing mediated by biomaterials, cells, drugs. Among available bone‐fractured models, calvarial defect is a simple adequate option when researchers investigate intra‐membranous formation influence their regenerative solutions. However, conventional surgical tools to perform calvaria osteotomies (i.e., trephine bur mounted on dental handpiece, DS) can affect subjacent tissues skull, which dura mater...