A5088125885- Cancer, Hypoxia, and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- Microtubule and mitosis dynamics
- Liver physiology and pathology
- RNA modifications and cancer
- Drug Transport and Resistance Mechanisms
- Cancer Research and Treatments
- Cancer Genomics and Diagnostics
- Chemotherapy-induced organ toxicity mitigation
- Metabolomics and Mass Spectrometry Studies
- Trace Elements in Health
- Metabolism and Genetic Disorders
- Diagnosis and treatment of tuberculosis
- Histone Deacetylase Inhibitors Research
- Bioinformatics and Genomic Networks
- Tuberculosis Research and Epidemiology
- Ubiquitin and proteasome pathways
- Cancer, Lipids, and Metabolism
- Cancer Mechanisms and Therapy
- Mycobacterium research and diagnosis
- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- Cancer therapeutics and mechanisms
- Ferroptosis and cancer prognosis
- ATP Synthase and ATPases Research
Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol
2022-2025
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2023
Institute of Predictive and Personalized Medicine of Cancer
2021-2022
Approximately 20 % of hepatoblastomas (HBs) exhibit a poor response to conventional chemotherapy due mechanisms chemoresistance (MOCs), such as reduced intracellular drug accumulation. This study evaluated the role transportome in multidrug resistance (MDR) HB. Paired HB and adjacent liver tissue samples (n = 19) HB-derived cell lines (HepG2, HuH6) were analyzed for their resistome characterization at mRNA (RT-qPCR, Taqman Low-Density Array, sequencing) protein (western blot,...
Management of hepatoblastoma (HB), the most frequent pediatric liver cancer, is based on surgical resection and perioperative chemotherapy regimens. In this study, we aimed to identify actionable targets in HB assess efficacy molecular therapies preclinical models HB. Paired tumor adjacent tissues from 31 HBs a validation set 50 were analyzed using RNA-seq, SNP, methylation arrays. IGF2 overexpression was identified as top targetable driver, present 71% (22/31). IGF2high tumors displayed...
Hepatoblastoma (HB) is the predominant form of pediatric liver cancer, though it remains exceptionally rare. While treatment outcomes for children with HB have improved, patients advanced tumors face limited therapeutic choices. Additionally, survivors often suffer from long-term adverse effects due to treatment, including ototoxicity, cardiotoxicity, delayed growth, and secondary tumors. Consequently, there a pressing need identify new effective strategies HB. Computational methods predict...
MacroH2A histone variants have a function in gene regulation that is poorly understood at the molecular level. We report macroH2A1.2 and macroH2A2 modulate transcriptional ground state of cancer cells how they respond to inflammatory cytokines. Removal hepatoblastoma affects contact frequency promoters distal enhancers coinciding with changes enhancer activity or preceding them response cytokine tumor necrosis factor alpha. Although macroH2As regulate genes both directions, globally...
Hepatoblastoma (HB) is a rare childhood tumour with an evolving molecular landscape. We present the first comprehensive metabolomic analysis using untargeted and targeted liquid chromatography coupled to high-resolution tandem mass spectrometry (LC-MS/MS) of paired non-tumour surgical samples in HB patients (n = 8 pairs). This study demonstrates that landscape distinct from (NT) liver tissue, 35 differentially abundant metabolites mapping onto pathways such as fatty acid transport,...
<b><i>Introduction:</i></b> Hepatocellular carcinoma and hepatoblastoma are two liver cancers characterized by gene deregulations, chromosomal rearrangements, mutations in Wnt/beta-catenin (Wnt) pathway-related genes. LHX2, a transcriptional factor member of the LIM homeobox family, has important functions embryogenesis development. LHX2 is oncogenic many solid tumors leukemia, but its role cancer unknown. <b><i>Methods:</i></b> We analyzed...
Resistance to conventional chemotherapy remains a huge challenge in the clinical management of hepatoblastoma, most common liver tumor childhood. By integrating gene expression data hepatoblastoma patients into perturbation prediction tool Connectivity Map, we identified widely used anthelmintic mebendazole as drug circumvent chemoresistance permanent and patient-derived xenograft cell lines that are resistant cisplatin, therapeutic backbone treatment. Viability assays clearly indicated...
<p>Supplementary Figures and Tables</p>
<div>Abstract<p>Management of hepatoblastoma (HB), the most frequent pediatric liver cancer, is based on surgical resection and perioperative chemotherapy regimens. In this study, we aimed to identify actionable targets in HB assess efficacy molecular therapies preclinical models HB. Paired tumor adjacent tissues from 31 HBs a validation set 50 were analyzed using RNA-seq, SNP, methylation arrays. <i>IGF2</i> overexpression was identified as top targetable driver,...
<p>Supplementary Figures and Tables</p>
<div>Abstract<p>Management of hepatoblastoma (HB), the most frequent pediatric liver cancer, is based on surgical resection and perioperative chemotherapy regimens. In this study, we aimed to identify actionable targets in HB assess efficacy molecular therapies preclinical models HB. Paired tumor adjacent tissues from 31 HBs a validation set 50 were analyzed using RNA-seq, SNP, methylation arrays. <i>IGF2</i> overexpression was identified as top targetable driver,...
<div>Abstract<p>Management of hepatoblastoma (HB), the most frequent pediatric liver cancer, is based on surgical resection and perioperative chemotherapy regimens. In this study, we aimed to identify actionable targets in HB assess efficacy molecular therapies preclinical models HB. Paired tumor adjacent tissues from 31 HBs a validation set 50 were analyzed using RNA-seq, SNP, methylation arrays. <i>IGF2</i> overexpression was identified as top targetable driver,...
<p>Supplementary Figures and Tables</p>
<p>Supplementary Figures and Tables</p>
ABSTRACT The granuloma is a complex structure, contributing to the overall spectrum of tuberculosis (TB). We characterised 44 fresh human pulmonary TB lesion samples from 13 patients (drug-sensitive and multi-drug resistant TB) undergoing therapeutic surgery using RNA-Sequencing. confirmed clear separation between adjacent non-lesional tissue, with consistently displaying increased inflammatory profile despite heterogeneity. Using weighted correlation network analysis, we identified 17...
Abstract Background and Aims: Management of hepatoblastoma (HB), the most frequent pediatric liver cancer, is based on surgical resection perioperative platin-based regimens, commonly cisplatin. Here, we aimed to identify actionable targets in HB assess efficacy molecular therapies cell lines, organoids murine models. Methods: Paired tumor adjacent tissues from 31 resected HBs a validation set 50 were analyzed at transcriptomic, genomic epigenomic level using RNAseq, SNP methylation arrays,...
Abstract Childhood liver cancers hepatoblastoma (HB) and hepatocellular carcinoma (HCC) are rare diseases but with a rising incidence. HEMNOS (Hepatocellular malignant neoplasm, not otherwise specified) is recent entity histopathological features of HB HCC. Current chemotherapy treatments effective to shrink tumor before surgery, nonetheless can cause severe lifelong adverse effects for patients aggressive metastatic or HCC (~20% die due the disease). The diagnosis key assign therapeutic...
Abstract Background: The main pediatric liver tumors are hepatoblastoma (HB) and, to a lesser extent, hepatocellular carcinoma (HCC). HB appears at an early age (&lt;3 years) while HCC is diagnosed mainly in older children (&gt;8 or adolescents and it usually associated underlying metabolic diseases. HEM-NOS (Hepatocellular malignant neoplasm, not otherwise specified) recent entity with histopathological features of HCC. Due the rarity disease (&lt;1 case per million children),...
Abstract Background and Aims: Management of hepatoblastoma (HB), the most frequent pediatric liver cancer, is based on surgical resection perioperative chemotherapy regimens, commonly cisplatin. Here, we aimed to identify actionable targets in HB assess efficacy molecular therapies preclinical models HB.Methods: Paired tumor adjacent tissues from 31 resected HBs a validation set 50 were analyzed at transcriptomic, genomic epigenomic level using RNAseq, SNP methylation arrays, respectively....