A5100675101- Gut microbiota and health
- Probiotics and Fermented Foods
- Clostridium difficile and Clostridium perfringens research
- Liver Disease Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Diet and metabolism studies
- IL-33, ST2, and ILC Pathways
- Diet, Metabolism, and Disease
- Toxoplasma gondii Research Studies
- Liver Disease and Transplantation
- Genetic factors in colorectal cancer
- Pharmacological Effects of Natural Compounds
- Gastrointestinal motility and disorders
- Infant Health and Development
- Machine Learning in Healthcare
- Gestational Trophoblastic Disease Studies
- Spondyloarthritis Studies and Treatments
- biodegradable polymer synthesis and properties
- Inflammasome and immune disorders
- GABA and Rice Research
- Viral-associated cancers and disorders
- Multiple and Secondary Primary Cancers
- Ginseng Biological Effects and Applications
- Immune Response and Inflammation
- Gene expression and cancer classification
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2019-2024
First Affiliated Hospital Zhejiang University
2020-2024
Huazhong University of Science and Technology
2024
National Clinical Research Center for Digestive Diseases
2022-2024
Henan Institute of Science and Technology
2024
Qingdao University of Science and Technology
2024
Zhejiang University
2019-2023
China Agricultural University
2023
National Center for Infectious Diseases
2021
National Clinical Research
2021
Our work revealed that A. muciniphila attenuated APAP-induced liver injury by alleviating oxidative stress and inflammation in the liver, its hepatoprotective effect was accompanied activation of PI3K/Akt pathway mediated regulation composition metabolic function intestinal microbiota. This finding suggested microbial community is a non-negligible impact on drug metabolism probiotic administration could be potential therapy for drug-induced injury.
Inflammatory bowel disease (IBD) is an idiopathic inflammatory with a high incidence. Multiple factors including dietary composition contribute to its occurrence. Recently, ketogenic diet which consists of proportion fat and low carbohydrates has gained great popularity. Our study aimed explore the effect on IBD potential mechanisms. C57BL/6 mice were given or control for month was induced by 2% DSS in drinking water last week. Gut histology, cytokines chemokines, gut microbiota metabolism...
Gut microbiota are closely related to lipopolysaccharide (LPS)-induced acute lung injury (ALI). Akkermansia muciniphila (A. muciniphila) maintains the intestinal barrier function and regulates balance of reduced glutathione/oxidized glutathione. However, it may be useful as a treatment strategy for LPS-induced injury. Our study aimed explore whether A. could improve by affecting gut microbiota. The administration effectively attenuated tissue damage significantly decreased oxidative stress...
Acetaminophen (APAP) overdose is the most common driver of drug-induced liver injury (DILI) worldwide, and gut microbiome plays a crucial role in this process. In study, we estimated effect Bifidobacterium longum R0175 on APAP-induced mice discovered that B. alleviated by diminishing inflammation, reducing oxidative stress levels, inhibiting hepatocyte death improving dysbiosis. Further studies revealed antioxidative effects were primarily due to activation Nrf2 pathway, which was supported...
The gut microbiota is considered a key factor in pathogenesis and progression of inflammatory bowel disease (IBD). bacterium Pediococcus pentosaceus LI05 alleviated host inflammation by maintaining the epithelial integrity, modulating immunity, metabolism, but its effect on IBD remains unclear. present study aimed to investigate role mechanisms P. LI05. Mice were administered or phosphate-buffered saline once daily oral gavage for 14 days, colitis was induced providing mice 2% DSS-containing...
Summary Millions of people die from liver diseases annually, and failure is one the three major outcomes disease. The gut microbiota plays a crucial role in diseases. This study aimed to explore effects Lactobacillus casei strain Shirota (LcS), probiotics used widely around world, on acute injury (ALI), as well underlying mechanism. Sprague Dawley rats were intragastrically administered LcS suspensions or placebo once daily for 7 days before induction ALI by intraperitoneal injection...
Clostridioides difficile is a common cause of nosocomial infection. Antibiotic-induced dysbiosis in the intestinal microbiota core C. infection (CDI). Akkermansia muciniphila plays an active role maintaining gastrointestinal balance and might offer protective effects on CDI as probiotics. Here, we investigated mechanisms A. CDI. C57BL/6 mice (n = 29) were administered Muc T (3 × 109 CFUs, 0.2 mL) or phosphate-buffered saline (PBS) by oral gavage for 2 weeks. Mice pretreated with antibiotic...
Abstract Liver disease, a major health concern worldwide, is serious and progressive disorder. Herein, we not only established mouse model of DEN+CCl 4 -induced primary liver disease but also collected clinical human samples to investigate longitudinal alterations in the gut mycobiome. As advanced, integrity was disrupted, mycobiota disturbed models. The metabolites associated with hepatocellular carcinoma (HCC) differed from those cirrhotic phase as follows: levels stercobilin aflatoxin B1...
Abstract Background The human gut microbiome plays a critical role in the carcinogenesis of colorectal cancer (CRC). However, comprehensive analysis interaction between host and is still lacking. Results We found correlations change abundance microbial taxa, butyrate-related colonic metabolites, methylation-associated gene expression tumour mucosa tissues compared with adjacent normal tissues. increase genus Fusobacterium was correlated decrease level 4-hydroxybutyric acid (4-HB)...
The probiotic Lactobacillus acidophilus LA14 is widely used worldwide, but its effect on liver diseases has not been elucidated. We explored the protective of L. using rats with d -galactosamine-induced injury.
Liver failure is a serious hepatic dysfunction with high mortality. This work aimed to investigate the effect of famous probiotic and drug, Lactobacillus reuteri DSM 17938, on liver in rats. Sprague-Dawley rats were gavaged 3 × 10
Acute liver failure is a severe disorder that poses considerable global challenges. Previous studies on Bifidobacterium longum R0175 have mainly focused its psychotropic functions. The current research the protective efficacy of B. against acute caused by d-galactosamine (d-GalN) in rats and further tested hypothesis exerted liver-protective effects affecting intestinal microbiota fecal metabolites inhibiting inflammation. We found oral gavage markedly reduced severity injury d-GalN-treated...
Summary The gut microbiota plays pivotal roles in liver disease onset and progression. protective effects of Lactobacillus salivarius Li01 on diseases have been reported. In this study, we aimed to detect the effect L. thioacetamide (TAA)‐induced acute injury hyperammonaemia. C57BL/6 mice were separated into three groups given a gavage or phosphate‐buffered saline for 7 days. Acute hyperammonaemia induced with an intraperitoneal TAA injection. decreased mortality serum transaminase levels...
Autoimmune hepatitis (AIH) is a progressive inflammation-associated liver injury. Pyroptosis novel inflammatory programmed cell death wherein gasdermin D (GSDMD) serves as the executioner. Our work challenged Gsdmd-/- mice with concanavalin A (ConA) to try unveil actual role of GSDMD in AIH. After ConA injection, exhibited more severe damage characterized by lower survival rate, extensive hepatocyte necrosis and apoptosis, higher serum transaminase levels, indicating protection ConA-induced...
Diets rich in fiber may provide health benefits and regulate the gut microbiome, which affects immune system. However, role of dietary Clostridioides difficile infection (CDI) is controversial. Here, we investigated use fermentable fibers, such as inulin or pectin, to replace insoluble cellulose explore how C. -induced colitis mice through intestinal microecology metabolomics. Using VPI 10463, generated a mouse model antibiotic-induced CDI. We evaluated disease outcomes microbial community...
Acute liver failure (ALF) is a clinical condition with many causes, fast progression, and poor prognosis. Previous research has indicated that microbial factors have role in ALF, but clear picture yet to emerge.To investigate the specific involvement of metabolites ALF development, we pretreated D-GalN/LPS-induced mice indole derivatives, an influential class gut metabolites.Contrary their typical as anti-inflammatory agents host, indole-3-acetic acid (IAA), indole-3-lactic (ILA),...
The number of cancer survivors has increased rapidly, and there is a higher risk developing second cancer. Whether prior malignancy could affect survival outcomes unknown. We aimed to investigate the clinical characteristics prognostic malignancies in patients with gastric Patient data were extracted from Surveillance, Epidemiology, End Results (SEER) database. used Kaplan-Meier method, competing models, Cox regression models evaluate impact on outcomes. Among 71,809 primary cancer, 6667...
Bacillus cereus (B. cereus) functions as a probiotic in animals, but the underlying mechanisms remain unclear. We aim to evaluate protective effects and definite mechanism by which oral administration of B. prevents D-galactosamine-induced liver injury rats. Twenty-one Sprague–Dawley rats were equally assigned three groups (N = 7 animals per group). ATCC11778 (2x109 colony-forming units/ml) was administered group via gavage, phosphate-buffered saline positive control (PC) negative (NC) for 2...