A5059747108- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Orthopedic Infections and Treatments
- Bone health and treatments
- Bone Metabolism and Diseases
- Osteoarthritis Treatment and Mechanisms
- Bone Tissue Engineering Materials
- Knee injuries and reconstruction techniques
- Shoulder Injury and Treatment
- Bone health and osteoporosis research
- Hip and Femur Fractures
- Bone fractures and treatments
- Bone and Joint Diseases
- Inflammatory mediators and NSAID effects
- Hip disorders and treatments
- Advanced materials and composites
- Tendon Structure and Treatment
- Spine and Intervertebral Disc Pathology
- Anesthesia and Pain Management
- Dental Implant Techniques and Outcomes
- Ultrasound and Hyperthermia Applications
- Pelvic and Acetabular Injuries
- Genetic Associations and Epidemiology
- Spinal Fractures and Fixation Techniques
- Sports injuries and prevention
Second Affiliated Hospital of Zhejiang University
2015-2024
Zhejiang University
2014-2023
Zhejiang Lab
2021-2023
Zhejiang University Medical College Affiliated Stomatological Hospital
2017-2022
Sir Run Run Shaw Hospital
2018
Zhejiang Hospital
2018
Health First
2017
National Natural Science Foundation of China
2017
Indiana University School of Medicine
2015-2016
Hangzhou Xixi hospital
2016
Abstract Desktop three-dimensional (3D) printers (D3DPs) have become a popular tool for fabricating personalized consumer products, favored low cost, easy operation and other advantageous qualities. This study focused on the potential using D3DPs to successfully, rapidly economically print customized implants at medical clinics. An experiment was conducted D3DP-printed anterior cruciate ligament surgical implant rabbit model. A well-defined, orthogonal, porous PLA screw-like scaffold...
COX-2, an inducible enzyme, is associated with inflammatory diseases and carcinogenesis. Overexpression of COX-2 occurs in many human malignancies, including osteosarcoma. positivity form 67 to 92% osteosarcoma, expresses 141-fold more cancer stem cell spheres than daughter adherent cells. In our study, we have reported that celecoxib, a cyclooxygenase-2 inhibitor, induces apoptosis osteosarcoma line MG-63 via down-regulation PI3K/Akt. It has been confirmed celecoxib enhances cytotoxic...
Abstract Wollastonite (CaSiO3; CSi) ceramic is a promising bioactive material for bone defect repair due to slightly fast degradation of its porous constructs in vivo . In our previous strategy some key features CSi have been significantly improved by dilute magnesium doping regulating mechanical properties and biodegradation. Here we demonstrate that 6 ~ 14% Ca substituted Mg (CSi-Mgx, x = 6, 10, 14) can enhance the strength (>40 MPa) but not compromise biological performances 3D printed...
Osteolysis is an osteolytic lesion featured by enhanced osteoclast formation and potent bone erosion. Lacking of effective regimen for treatment the pathological process highlights importance identifying agents that can suppress differentiation function osteoclast. Artemether a natural compound derived from Artemisia annua L. it popularized malaria. In present study, we demonstrated artemether could RANKL-induced osteoclastogenesis expression marker genes such as tartrate-resistant acid...
The objective of the present study was to perform an in vivo assessment a novel silk-collagen scaffold for anterior cruciate ligament (ACL) reconstruction. First, fabricated by combining sericin-extracted knitted silk fibroin mesh and type I collagen mimic components ligament. Scaffolds were electron-beam sterilized rolled up replace ACL 20 rabbits group, autologous semitendinosus tendons used reconstruct autograft control group. At 4 16 weeks after surgery, grafts retrieved analyzed...
The regeneration and repair of damaged load-bearing segmental bones require considerable mechanical strength for the artificial implants. ideal biomaterials should also facilitate production porous implants with high bioactivity desirable stimulating new bone growth. Here we developed a mechanically strong, highly bioactive dilute magnesium-doped wollastonite (CaSiO3-Mg; CSi-Mg) scaffold by robocasting technique. sintered scaffolds had interconnected pores 350 µm in size over 50% porosity...
Engineering scaffolds combinging natural biomineral and artificially synthesized material hold promising potential for bone tissue regeneration. In this study, novel bioactive calcium sulfate/oyster shell (CS/OS) composites were prepared. Comparing to CS scaffold, the CS/OS with a controllable degradation rate displayed enhanced mineral nodule formation, higher alkaline phosphate (ALP) activity increased proliferation while treated osteocytes. group, elevated mRNA levels of key osteogenic...
Tendinopathy is still a great challenge in clinical practice, and the role of platelet-rich plasma (PRP) controversial. The influence leukocytes on tendinopathy at an early stage has not been defined so far.To compare effects leukocyte-rich PRP (Lr-PRP) leukocyte-poor (Lp-PRP) Achilles when applied stage.Controlled laboratory study.A rabbit model was induced by collagenase injection. A week later, treatments were randomly local tendon lesions: (1) 200 μL Lr-PRP (16 legs), (2) Lp-PRP (3)...
Sex steroids are thought to contribute the pathogenesis of osteoarthritis (OA). This study investigated causal role sex in site- and sex-specific OA risk joint replacement surgery using Mendelian randomization (MR) method.Instrumental variables for estradiol, dehydroepiandrosterone sulfate, testosterone (T), dihydrotestosterone (DHT) were selected. We used inverse variance weighting (IVW) approach as main MR method estimate effects based on summary-level data from genome-wide association...