A5104160311- Bone Tissue Engineering Materials
- Orthopaedic implants and arthroplasty
- Dental Implant Techniques and Outcomes
- Dental materials and restorations
- Spine and Intervertebral Disc Pathology
- Calcium Carbonate Crystallization and Inhibition
- Additive Manufacturing and 3D Printing Technologies
- Spinal Cord Injury Research
- Osteoarthritis Treatment and Mechanisms
- Bone health and treatments
- Bone health and osteoporosis research
- Titanium Alloys Microstructure and Properties
- Toxoplasma gondii Research Studies
- MicroRNA in disease regulation
- Endodontics and Root Canal Treatments
- Bone fractures and treatments
- Inflammasome and immune disorders
- 3D Printing in Biomedical Research
- Curcumin's Biomedical Applications
- Spinal Fractures and Fixation Techniques
- Bone Metabolism and Diseases
- Orthopedic Infections and Treatments
- Inflammatory mediators and NSAID effects
- Autophagy in Disease and Therapy
- Hip disorders and treatments
First Affiliated Hospital Zhejiang University
2010-2024
Zhejiang University
2015-2024
Clinical Orthopaedics and Related Research
2018
Hangzhou Xixi hospital
2014-2017
Indiana University School of Medicine
2016-2017
Chinese Academy of Agricultural Sciences
2008-2009
Institute of Animal Sciences
2009
Tianjin Agricultural University
2008
The pore architecture of porous scaffolds is a critical factor in osteogenesis, but it challenge to precisely configure strut-based because the inevitable filament corner and geometry deformation. This study provides tailoring strategy which series Mg-doped wollastonite with fully interconnected networks curved architectures called triply periodic minimal surfaces (TPMS), are similar cancellous bone, fabricated by digital light processing technique. sheet-TPMS geometries (s-Diamond,...
Three-dimensional (3D) printing bioactive ceramics have demonstrated alternative approaches to bone tissue repair, but an optimized materials system for improving the recruitment of host osteogenic cells into defect and enhancing targeted repair thin-wall craniomaxillofacial defects remains elusive. Herein we systematically evaluated role side-wall pore architecture in direct-ink-writing bioceramic scaffolds on mechanical properties capacity rabbit calvarial defects. The pure calcium...
Abstract Osteoporosis is a common disease characterized by low bone mineral density (BMD) and trauma fractures, mainly resulting from exceeding resorption osteoclasts over formation osteoblasts. Circulating monocytes are directly involved in osteoclastogenesis, lncRNAs believed to be the osteoblast differentiation. However, no study has been conducted identify roles of lncRNA circulating associated with human osteoporosis. In this study, we found significant upregulation DANCR blood...
Spatial dimension of pores and interconnection in macroporous scaffolds is particular importance facilitating endogenous cell migration bone tissue ingrowth. However, it still a challenge to widely tune structure parameters by conventional methods because inevitable pore geometrical deformation poor interconnectivity. Here, the long-term vivo biological performances nonstoichiometric bioceramic with different dimensions were assessed critical-size femoral defect model. The 6% Mg-substituted...
The pore morphology design of bioceramic scaffolds plays a substantial role in the induction bone regeneration. Specifically, effects different scaffold geometry designs on angiogenesis and new regeneration remain unclear. Therefore, we fabricated Mg/Sr co-doped wollastonite (MS-CSi) with three geometries (gyroid, cylindrical, cubic) compared their osteogenesis vitro vivo. MS-CSi were by digital light processing (DLP) printing technology. structure, mechanical properties, degradation rate...
Using artificial biomaterials in bone regenerative medicine for highly efficient osteoconduction into the defect to decrease healing time is still a challenge. In this research, magnesium (Mg)-doped wollastonite (∼10% Mg was substituted calcium (Ca) β-CaSiO3) (CSi-Mg10) bioceramic scaffolds with ultrahigh mechanical strength were fabricated using ceramic ink writing three dimensional (3D) printing. To evaluate potential of other additives on new regeneration efficiency, β-tricalcium...
The regeneration and repair of damaged load-bearing segmental bones require considerable mechanical strength for the artificial implants. ideal biomaterials should also facilitate production porous implants with high bioactivity desirable stimulating new bone growth. Here we developed a mechanically strong, highly bioactive dilute magnesium-doped wollastonite (CaSiO3-Mg; CSi-Mg) scaffold by robocasting technique. sintered scaffolds had interconnected pores 350 µm in size over 50% porosity...
Abstract Background Spinal cord injury (SCI) is a severe central nervous system trauma. The present study aimed to evaluate the effect of HIF-1α on inflammation in spinal uncover molecular mechanisms anti-inflammation. Results was reduced SCI model rats and activation TNF-α, IL-1β, IL-6 IL-18 levels rats. Meanwhile, Circ 0001723 expression down-regulated miR-380-3p up-regulated In vitro model, down-regulation promoted levels, compared with control negative group. However, over-expression...
Osteochondral defect refers to the damage of cartilage as well subchondral bone. Cartilage tissue engineering focusing on regeneration and disregarding bone always leads partial damage, resulting in poor mechanical physiological properties. A scaffold suitable for situ inductive both types tissues is urgently needed. In this study, a biphasic integrated by macro-porous fibrin 3D-printed wollastonite (containing 8% MgSiO3 (CS-Mg8)) scaffolds, either preloaded with rabbit marrow mesenchymal...
Mechanical strength and its long-term stability of bioceramic scaffolds is still a problem to treat the osteonecrosis femoral head. Considering diopside (DIO) ceramic but poor mechanical strength, we developed DIO-based porous composites via dilute magnesium substituted wollastonite reinforcing three-dimensional (3D) printing. The experimental results showed that secondary phase (i.e. 10% substituting calcium silicate; CSM10) could readily improve sintering property (DIO/CSM10-x, x = 0-30)...
Bioactive ceramics are promising candidates as 3D porous substrates for bone repair in regenerative medicine. However, they often inefficient clinical applications due to mismatching mechanical properties and compromised biological performances. Herein, the additional Sr dopant is hypothesized readily adjust biodegradable of dilute Mg-doped wollastonite bioceramic scaffolds with different pore geometries (cylindrical-, cubic-, gyroid-) by ceramic stereolithography. The results indicate that...
This study describes the fabrication and biological evaluation of core-shell bilayered bioceramic microspheres with adjustable compositional distribution via a coaxial bilayer capillary system. Beyond homogeneous hybrid composites, varying diameter nozzles composition slurries makes it easy to create β-tricalcium phosphate (CaP)/β-calcium silicate (CaSi) controllable in core or shell layer. Primary investigations vitro revealed that biodegradation could be adjusted by thickness poorly...
Tissue integration of orbital implants, following enucleation treatment, represents a challenge for rapid fibrovascularization, long-time stability, anti-infection, and even induction vascule regeneration. The objective this study was to develop porous calcium–magnesium silicate materials, with good bioactivity, antibacterial potential as new fillers. Three-dimensional (3D) diopside scaffolds (low dissolvability) were fabricated by direct ceramic ink writing assembly then followed one-step...
This study aimed to describe the 25-hydroxyvitamin D (25(OH)D) and parathyroid hormone (PTH) status of Southeast Chinese individuals influenced by season. The secondary aim was determine cutoff for sufficient 25(OH)D in a four-season region. From January 2011 June 2014, total 17 646 were evaluated our study. serum levels PTH detected simultaneously 5579 cases. A intact measured electrochemiluminescent immunoassay. distribution concentration, prevalence seasonal variability studied. mean...
Abstract Pore architecture in bioceramic scaffolds plays an important role facilitating vascularization efficiency during bone repair or orbital reconstruction. Many investigations have explored this relationship but lack integrating pore architectural features a scaffold, hindering optimization of parameters (geometry, size and curvature) to improve consequently clinical outcomes. To address challenge, we developed design strategy fabricate different architectures (cube, gyroid hexagon)...