A5101790090- Bone Tissue Engineering Materials
- Mesenchymal stem cell research
- Recycling and utilization of industrial and municipal waste in materials production
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- 3D Printing in Biomedical Research
- Microstructure and Mechanical Properties of Steels
- Metallurgical Processes and Thermodynamics
- Advanced ceramic materials synthesis
- Radiomics and Machine Learning in Medical Imaging
- Reconstructive Facial Surgery Techniques
- Breast Implant and Reconstruction
- Adipose Tissue and Metabolism
- Reconstructive Surgery and Microvascular Techniques
- High Temperature Alloys and Creep
- Nanocomposite Films for Food Packaging
- Epigenetics and DNA Methylation
- Extraction and Separation Processes
- Nerve injury and regeneration
- Electrospun Nanofibers in Biomedical Applications
- Postharvest Quality and Shelf Life Management
- Colorectal Cancer Surgical Treatments
- Orthopaedic implants and arthroplasty
- Metal Extraction and Bioleaching
- Intermetallics and Advanced Alloy Properties
China Medical University
2008-2025
Wuhan Institute of Physics and Mathematics
2022-2025
Huazhong University of Science and Technology
2025
Wuhan National Laboratory for Optoelectronics
2022-2025
Chinese Academy of Sciences
2022-2025
Soochow University
2023-2025
Shanghai First People's Hospital
2016-2024
Shanghai Jiao Tong University
2015-2024
Nanjing University of Information Science and Technology
2024
Shanghai Institute of Technology
2020-2024
Non-small cell lung cancer (NSCLC) has long been one of the most lethal types due to its lack typical clinical symptoms at early stages and high risk tumour recurrence, even following complete surgical resection. Multicourse chemotherapy based on cisplatin (CDDP) is standard adjuvant treatment for NSCLC; however, benefits overall survival patients are limited. In this study, NSCLC cells possessing CDDP-resistant characteristics (N5CP cells), obtained from resection specimens with NSCLC, were...
The therapeutic method traditionally used in bone defect reconstruction is autologous grafting. most common problems affecting this type of repair approach are absorption and donor trauma. taken study overcomes these problems. Bone marrow stromal cells (BMSCs) provided the crucial seed cells. Fibrin biological scaffolds were formed by combining BMSCs with concentrated growth factor (CGF). isolated from Wistar rat femurs; CGF was prepared heart blood. Five groups created for comparative...
Biomaterial-based bone graft substitute with favorable mechanical and biological properties could be used as an alternative to autograft for large defect treatment. Here, apatite–collagen–polycaprolactone (Ap-Col-PCL) composite construct was developed unique nano–micro–macro hierarchical architectures by combining rapid prototyping (RP) fabrication technology a 3D functionalization strategy. Macroporous PCL framework fabricated using RP technology, then functionalized collagen incorporation...
Nitroreductase (NTR) is an important biomarker widely used to evaluate the degree of tumor hypoxia. Although a few optical methods have been reported for detecting nitroreductase at low concentration ranges, effective strategy monitoring in vivo without limits imaging depth still lacking. Herein, novel dual-mode NIR fluorescence and 19 F MRI agent, FCy7-NO2 , proposed We show that serves as not only rapid enhanced probe bioimaging tumors, but also MR chemical shift-sensitive contrast agent...
High glucose environment in diabetes mellitus induces the dysfunction of bone marrow-derived mesenchymal stromal cells (BMSCs) and impairs regeneration. Chrysin is a natural polyphenol with outstanding anti-inflammation anti-oxidation ability. However, whether how chrysin affects BMSCs high conditions remain poorly understood. The present study aimed to explore effects underlying mechanisms on exposed environment.Cell viability was detected by cell counting kit 8 assay...
Cell sheet-based scaffold-free technology holds promise for tissue engineering applications and has been extensively explored during the past decades. However, efficient harvest handling of cell sheets remain challenging, including insufficient extracellular matrix content poor mechanical strength. Mechanical loading widely used to enhance production in a variety types. currently, there are no effective ways apply sheets. In this study, we prepared thermo-responsive elastomer substrates by...
Bone injuries induced by accidents or bone-related disease have dramatically increased in the past decades. The application of biomaterials has become an inextricable part treatment for new bone formation and regeneration. Different from traditional bone-regeneration materials, injectable biomaterials-ranging bioceramics to polymers-have been applied as a means promoting surgery with minimal intervention approach. In this review, we summarize most recent developments minimally invasive...
Photodynamic therapy (PDT) holds great potential in cancer treatment, leveraging photosensitizers (PSs) to deliver targeted therapy. Fluorination can optimize the physicochemical and biological properties of PSs for better PDT performance. Here, we report some high-performance multifunctional specifically designed by fluorinating aza-BODIPY with perfluoro-tert-butoxymethyl (PFBM) groups. plays several roles, including enhancing selective cell uptake, plasma membrane (PM) targeting, inducing...
BACKGROUND: BAD (Bcl2-associated death promoter), a member of the Bcl2 proapoptotic family, promotes cell apoptosis by sequestering prosurvival proteins Bcl-XL and from BAK BAX in nucleated cells. is also expressed platelets, playing role regulating platelet lifespan, apoptosis, clearance. However, whether regulates activation arterial thrombosis remains unclear. METHODS: The was investigated using BAD-deficient mice ( Bad −/− ), vitro functional studies, models. regulatory effect on energy...
Optimal osseointegration has been recognized as a pivotal factor in determining the long-term success of biomedical implants.In current study, highly carbonated hydroxyapatite (CHA) with carbonate contents 8, 12 and 16 wt% pure (HA) were fabricated via novel hydrothermal method deposited on titanium substrates to generate corresponding CHA bioceramic coatings (designated C8, C12 C16, respectively) HA C0).C8, C16 endowed nanoscale, hierarchical hybrid micro-/nanoscale microscale surface...
The combination of bone tissue scaffolds with osteogenic induction factors is an effective strategy to facilitate healing processes. Here, chitosan (CS)/nano-hydroxyapatite (HA) containing simvastatin (SIM)-loaded PLGA microspheres were fabricated by combining a freeze-drying technique modified water-oil-water emulsion method. CS/HA weight ratio 1:2 was selected analyzing the effect HA content on micro-architecture, mechanical strength, and biocompatibility scaffold. Drug release kinetics...
Abstract Many drugs can pass through the placenta and cause adverse effects on foetus. Thus, during Caesarean section for puerperas who have contraindications intravertebral anaesthesia, use of proper that sedative, analgesic without foetus is important. In this study, we investigated effect placental transfer dexmedetomidine under general anaesthesia. Thirty‐eight were randomly divided to receive or saline before anaesthesia induction operation. The dexmedetomidine‐treated parturients had...
Recurrent laryngeal nerve (RLN) injury remains a challenge due to the lack of effective treatments. In this study, we established new drug delivery system consisting tube Heal-All Oral Cavity Repair Membrane loaded with laminin and neurotrophic factors tested its ability promote functional recovery following RLN injury. We created recombinant fusion proteins brain-derived factor (BDNF) glial cell line-derived (GDNF) fused laminin-binding domains (LBDs) in order prevent neurotrophin...