A5060578410- Pulmonary Hypertension Research and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Electrospun Nanofibers in Biomedical Applications
- Renal Diseases and Glomerulopathies
- Mesenchymal stem cell research
- Bone Tissue Engineering Materials
- Extracellular vesicles in disease
- Eicosanoids and Hypertension Pharmacology
- Neonatal Respiratory Health Research
- Estrogen and related hormone effects
- Chronic Kidney Disease and Diabetes
- RNA modifications and cancer
- Wound Healing and Treatments
- Ovarian function and disorders
- Genomics, phytochemicals, and oxidative stress
- MicroRNA in disease regulation
- Congenital heart defects research
- Head and Neck Surgical Oncology
- Dental materials and restorations
- Tissue Engineering and Regenerative Medicine
- Neuroscience and Neuropharmacology Research
- ATP Synthase and ATPases Research
- Vascular anomalies and interventions
- Laser-Ablation Synthesis of Nanoparticles
- Orthopaedic implants and arthroplasty
University of Arizona
2021-2025
University Medical Center
2025
University of Phoenix
2023-2024
Hebei University of Technology
2019-2024
University of Miami
2009-2022
Phoenix (United States)
2022
Huashan Hospital
2020
Fudan University
2020
University of Shanghai for Science and Technology
2020
SleepMed
2019
The relevance of hormones in idiopathic pulmonary fibrosis (IPF), a predominantly male lung disease, is unknown.
Electrospun composite nanofibrous scaffolds have been regarded as a potential carrier for local drug delivery to prevent tumor recurrence. Herein, model (paclitaxel) was creatively loaded into lignin nanoparticles (PLNPs) and then encapsulated the polymer of poly (vinyl alcohol)/polyvinyl pyrrolidone which has fabricated membrane (PVA/PVP-PLNPs) use using electrospinning technique. The PVA/PVP-PLNPs membranes exhibited good particle distribution, mechanical properties, thermal stability...
Fibrosis can develop in nearly any tissue leading to a wide range of chronic fibrotic diseases. However, current treatment options are limited. In this study, we utilized an established aged mouse model bleomycin-induced lung fibrosis (BLM) test our hypothesis that may simultaneously multiple organs by evaluating skin and wound healing. was induced (18-22-month-old) C57BL/6 male mice intratracheal BLM administration. Allogeneic adipose-derived mesenchymal stromal cells (ASCs) or saline were...
ABSTRACT Background and objective IPF is a fatal debilitating lung disorder increasing in incidence worldwide. To date, two approved treatments only slow disease progression, have multiple side effects do not provide cure. MSC promising therapeutic potential as cell‐based therapy for many disorders based on the anti‐fibrotic properties of MSC. Methods Critical questions remain surrounding optimal source, timing efficacy therapies. The present study examines most effective sources Human were...
Abstract High‐affinity excitatory amino acid transporters (EAATs) are essential to terminate glutamatergic neurotransmission and prevent excitotoxicity. To date, five distinct EAATs have been cloned from animal human tissues: GLAST (EAAT1), GLT‐1 (EAAT2), EAAC1 (EAAT3), EAAT4, EAAT5. EAAT1 EAAT2 commonly known as glial glutamate transporters, whereas EAAT3, EAAT5 neuronal. EAAT4 is largely expressed in cerebellar Purkinje cells. In this study, using immunohistochemistry Western blotting, we...
The role that estrogens play in the aging lung is poorly understood. Remodeling of with thickening alveolar walls and reduction number peripheral airways well recognized. present study was designed to address whether estrogen deficiency would affect age-associated changes lungs female C57BL/6J mice. Lungs isolated from old mice (24 months old, estrogen-deficient) demonstrated decreased volume surface area. There no difference young (6 estrogen-replete). Estrogen replacement restored volume,...
Endothelial progenitor cells (EPCs) are the key of postnatal neovascularization, and mesenchymal stem (MSCs) possess pluripotent differentiation capacity contribute to tissue regeneration wound healing. Both EPCs MSCs critical repair process, which is hindered in diabetes mellitus. Diabetes has been shown decrease function these cells, whereas estrogen beneficial healing effects. However, role modulating EPC MSC biology unknown. We investigated effect on improving bone marrow (BM)-derived...
Background: MicroRNAs (miRNA) and other components contained in extracellular vesicles may reflect the presence of a disease. Lung tissue, sputum, sera individuals with idiopathic pulmonary fibrosis (IPF) show alterations miRNA expression. We designed this study to test whether urine and/or tissue derived exosomal miRNAs from IPF carry cargo that can promote fibrosis. Methods: Exosomes were isolated (U-IPFexo), lung myofibroblasts (MF-IPFexo), serum (n=16) age/sex-matched controls without...
Pulmonary arterial hypertension (PAH) is characterized by a progressive increase of pulmonary vascular resistance and obliterative remodeling that result in right heart hypertrophy, failure, premature death. The underlying mechanisms loss distal capillary endothelial cells (ECs) lesion formation remain unclear. Our recent single-cell RNA sequencing, spatial transcriptomics analysis, RNASCOPE, immunostaining analysis showed ECs accumulation were evident human PAH patients (PH) rodents....
Rare genetic variants and variation at loci in an enhancer SOX17 (SRY-box transcription factor 17) are identified patients with idiopathic pulmonary arterial hypertension (PAH) PAH congenital heart disease. However, the exact role of or mutations pathogenesis has not been reported.
Smoking is a known risk factor for the progression of chronic kidney diseases. However, its independent contribution to development ESRD and underlying molecular mechanism have not been well elucidated. Although higher in postmenopausal women according US Renal Data System, number who smoke on rise worldwide. Therefore, effects smoking estrogen status glomerular function structure were studied female B6 mice that ovariectomized at 3 (young) 15 mo (aged) age. The received either...
Despite increasing interest in the reversal of age-related processes, there is a paucity data regarding effects post-menopausal-associated estrogen loss on cellular function. We studied human adipose-derived mesenchymal stem cells (hASCs) isolated from women younger than 45 years old (pre-menopause, pre-hASC) or older 55 (post-menopause, post-hASC). In this study, we provide proof concept that ineffective functionality ASCs can be reversed to improve their ability promoting tissue repair....
Abstract We recently showed that 17β-estradiol (E2) treatment ameliorated type 2 diabetic glomerulosclerosis in mice part by protecting podocyte structure and function. Progressive damage is characterized foot process effacement, vacuolization, detachment of podocytes from the glomerular basement membrane, apoptosis. In addition, are highly dependent on preservation their actin cytoskeleton to ensure proper function survival. Because E2 administration prevented our study db/db has been shown...
Pulmonary arterial hypertension (PAH) is a devastating disease characterized by obliterative vascular remodeling and persistent increase of resistance, leading to right heart failure premature death. Understanding the cellular molecular mechanisms will help develop novel therapeutic approaches for PAH patients. Single-cell RNA sequencing (scRNAseq) analysis found that both FABP4 FABP5 were highly induced in endothelial cells (ECs) Egln1Tie2Cre (CKO) mice, which was also observed pulmonary...
Age-related increases in oxidant stress (OS) play a role regulation of estrogen receptor (ER) expression the kidneys. In this study, we establish that vivo 17β-estradiol (E2) replacement can no longer upregulate glomerular ER by 21 months age female mice (anestrous). We hypothesized advanced glycation end product (AGE) accumulation, an important source stress, contributes to these alterations. treated 19-month old ovariectomized with pyridoxamine (Pyr), potent AGE inhibitor, presence or...
Estrogen actions are largely dependent on the intracellular estrogen receptor (ER) levels. During aging decline of estrogens or ER leads to a loss in antiinflammatory protection and an increase oxidant stress due changes mitochondrial function. Estrogens/ER may also coordinate signaling between nucleus mitochondria through ERK activation, which paradoxically decreases expression. The expression transcriptional activation that occur with as well mitochondria-to-nuclear pathways have not been...