A5033528741- Aortic aneurysm repair treatments
- Angiogenesis and VEGF in Cancer
- Mesenchymal stem cell research
- Aortic Disease and Treatment Approaches
- Wound Healing and Treatments
- Vascular Procedures and Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Peripheral Artery Disease Management
- Diabetic Foot Ulcer Assessment and Management
- Cell Adhesion Molecules Research
- Cerebrovascular and Carotid Artery Diseases
- Central Venous Catheters and Hemodialysis
- Cancer, Hypoxia, and Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Infectious Aortic and Vascular Conditions
- Renal and Vascular Pathologies
- Vascular anomalies and interventions
- Cardiovascular Health and Disease Prevention
- Diversity and Career in Medicine
- Connective Tissue Growth Factor Research
- Electrospun Nanofibers in Biomedical Applications
- Intracranial Aneurysms: Treatment and Complications
- Acute Ischemic Stroke Management
- Cardiac Valve Diseases and Treatments
- Tissue Engineering and Regenerative Medicine
University of Miami
2016-2025
Clinical Research Management
2022
Codarts Rotterdam
2022
Bucheon University
2022
Society of Thoracic Surgeons
2020
Jackson Memorial Hospital
2009-2020
Dartmouth College
2019
University of Miami Health System
2019
Casa de Velázquez
2011-2016
University of Miami Hospital
2008-2015
Endothelial progenitor cells (EPCs) are essential in vasculogenesis and wound healing, but their circulating level numbers decreased diabetes. This study aimed to determine mechanisms responsible for the diabetic defect EPCs. Since mobilization of BM EPCs occurs via eNOS activation, we hypothesized that activation is impaired diabetes, which results reduced EPC mobilization. hyperoxia activates NOS other tissues, investigated whether restores mice through activation. Additionally, studied...
Notch and its ligands play critical roles in cell fate determination. Expression of ligand vascular endothelium defects phenotypes targeted mutants the pathway have suggested a role for signaling vasculogenesis angiogenesis. However, angiogenic that controls gene expression is unknown. We show here endothelial growth factor (VEGF) but not basic fibroblast can induce Notch1 ligand, Delta-like 4 (Dll4), human arterial cells. The VEGF-induced specific mediated through VEGF receptors 1 2...
We hypothesized that exposure to hyperbaric oxygen (HBO(2)) would mobilize stem/progenitor cells from the bone marrow by a nitric oxide (*NO) -dependent mechanism. The population of CD34(+) in peripheral circulation humans doubled response single 2.0 atmospheres absolute (ATA) O(2) for 2 h. Over course 20 treatments, circulating increased eightfold, although overall white cell count was not significantly increased. number colony-forming (CFCs) 16 +/- 26 3 CFCs/100,000 monocytes plated....
The exact significance of collateral endoleaks is unknown and a topic great debate. Because this uncertainty, some physicians choose to watch wait while others aggressively treat these leaks. purpose investigation was the evaluation efficacy two techniques used in treatment that occur after endovascular aneurysm repair.Patients with 33 angiographically proven type 2 underwent either transarterial inferior mesenteric artery embolization (n = 20) or direct translumbar 13) during an 18-month...
Objective: The exact significance of collateral endoleaks is unknown and a topic great debate. Because this uncertainty, some physicians choose to watch wait while others aggressively treat these leaks. purpose investigation was the evaluation efficacy two techniques used in treatment that occur after endovascular aneurysm repair. Methods: Patients with 33 angiographically proven type 2 underwent either transarterial inferior mesenteric artery embolization (n = 20) or direct translumbar 13)...
Hyperbaric oxygen (HBO) therapy has been used as an adjunctive for diabetic foot ulcers, although its mechanism of action is not completely understood. Recently, it shown that HBO mobilizes the endothelial progenitor cells (EPCs) from bone marrow eventually will aggregate in wound. However, gathering EPCs wounds impaired because decreased levels local stromal-derived factor-1α (SDF-1α). Therefore, we investigated influence on hypoxia-inducible factor 1 (HIF-1), which a central regulator...
Fibroblasts are stromal cells ubiquitously distributed in the body of nearly every organ tissue. These were previously considered to be “passive cells”, solely responsible for ensuring turnover extracellular matrix (ECM). However, their versatility, including ability switch phenotypes response tissue injury and dynamic activity maintenance specific homeostasis integrity have been recently revealed by innovation technological tools such as genetically modified mouse models single cell...
An in vitro model has been developed to study migration, survival, proliferation, and capillary-like differentiation of human microvascular endothelial cells (HMVECs) an environment that avoids tumor promoters complex matrices. HMVEC monolayers were plated, then induced form three-dimensional, networks by overlaying with type I collagen followed a second overlay embedded fibroblasts. Detachment migration into the matrix was triggered within hours collagen, fibroblasts stimulated survival...
To review the incidence and repair of inferior mesenteric arterial (IMA) type II endoleaks after endovascular abdominal aortic aneurysms.Fifty patients who underwent aneurysms were examined. If an endoleak was identified at 30-day postoperative computed tomography, conventional arteriography performed to identify eliminate its source. After exclusion attachment site leaks, a catheter placed selectively in superior artery (SMA). retrograde filling IMA aneurysm identified, coil embolization...