A5050365312- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Tissue Engineering and Regenerative Medicine
- Graphene and Nanomaterials Applications
- Silk-based biomaterials and applications
- Spine and Intervertebral Disc Pathology
- Nanoplatforms for cancer theranostics
- Musculoskeletal pain and rehabilitation
- Orthopaedic implants and arthroplasty
- Cellular Mechanics and Interactions
- biodegradable polymer synthesis and properties
- Polymer Surface Interaction Studies
- Magnetic properties of thin films
- Carbon and Quantum Dots Applications
- ZnO doping and properties
- Advanced Nanomaterials in Catalysis
- Osteoarthritis Treatment and Mechanisms
- Periodontal Regeneration and Treatments
- Urological Disorders and Treatments
- Medical Imaging and Analysis
- Nanocluster Synthesis and Applications
- Hydrogels: synthesis, properties, applications
- Angiogenesis and VEGF in Cancer
- Anatomy and Medical Technology
Soochow University
2016-2025
Harbin Medical University
2025
Fourth Affiliated Hospital of Harbin Medical University
2025
First Affiliated Hospital of Soochow University
2015-2023
Zhejiang Medicine (China)
2019-2023
National Engineering Research Center of Electromagnetic Radiation Control Materials
2022
University of Electronic Science and Technology of China
2022
The Orthopaedic Institute
2015-2017
Soochow University
2017
Tianjin University
2011-2015
Photodynamic therapy (PDT) is an oxygen-dependent light-triggered noninvasive therapeutic method showing many promising aspects in cancer treatment. For effective PDT, nanoscale carriers are often needed to realize tumor-targeted delivery of photosensitizers, which ideally should further target specific cell organelles that most vulnerable reactive oxygen species (ROS). Second, as critical for PDT-induced destruction, overcoming hypoxia existing the majority solid tumors important optimizing...
Abstract Reactive oxygen species (ROS) plays a critical role in tissue repair, including bone. Therefore, detecting and regulating ROS is essential for monitoring facilitating bone repair. In this study, the first time, spatiotemporal profile of ROS, represented by hydrogen peroxide (H 2 O ), injury microenvironment using photoacoustic imaging technique visualized. The levels significantly increase upon injury, peak at certain stage healing, then gradually decrease toward baseline level. To...
Abstract Bone repair in patients with osteoporosis remains a big challenge because their injury sites are often accompanied by an abnormal level of inflammation and reactive oxygen species (ROS). ROS is previously visualized, represented hydrogen peroxide (H 2 O ), the bone defects. In this study, H animals further it found that expression markedly higher than normal animals. Subsequently, composite hydrogel containing manganese dioxide (MnO )‐coated calcium phosphate microspheres loaded...
Implant-associated infection is a major threat affecting the success of orthopedic surgeries. Although various materials scavenge bacteria by generating reactive oxygen species (ROS), intrinsic inability ROS to distinguish from cells notably limits therapeutic effects. Here, we found that arginine carbon dots (Arg-CDs) were transformed exhibited supreme antibacterial and osteoinductive activity. We further designed Schiff base bond between Arg-CDs aldehyde hyaluronic acid/gelatin...
The critical factor determining the in vivo effect of bone repair materials is microenvironment, which greatly depends on their abilities to promote vascularization and formation. However, implant are far from ideal candidates for guiding regeneration due deficient angiogenic osteogenic microenvironments. Herein, a double-network composite hydrogel combining vascular endothelial growth (VEGF)-mimetic peptide with hydroxyapatite (HA) precursor was developed build an microenvironment repair....
The excessive reactive oxygen species (ROS) level, inflammation, and weak tissue regeneration ability after annulus fibrosus (AF) injury constitute an unfavorable microenvironment for AF repair. integrity is crucial preventing disc herniation discectomy; however, there no effective way to repair the AF. Herein, a composite hydrogel integrating properties of antioxidant, anti-inflammation, recruitment cells developed through adding mesoporous silica nanoparticles modified by ceria...
Abstract Nature has created many perfect helical microstructures, including DNA, collagen fibrils, and blood vessels, to achieve unique physiological functions. While previous studies have developed a number of microfabrication strategies, the preparation complex structures cell‐laden for biomimetic applications remains challenging. In this study, one‐step microfluidics‐based methodology is presented preparing hydrogel microfibers microfibers. Several types structures, multilayer...
Annulus fibrosus (AF) repair remains a challenge because of its limited self-healing ability. Endogenous strategies combining scaffolds and growth factors show great promise in AF repair. Although the unique beneficial characteristics decellularized extracellular matrix (ECM) tissue have been demonstrated, poor mechanical property ECM hydrogels largely hinders their applications regeneration. In present study, we combined polyethylene glycol diacrylate (PEGDA) annulus (DAFM) to develop an...
Abstract Repair of infectious bone defects remains a serious problem in clinical practice owing to the high risk infection and excessive reactive oxygen species (ROS) during early stage, residual bacteria delayed Osseo integrated interface later which jointly creates complex dynamic microenvironment leads non‐union. The melatonin carbon dots (MCDs) possess antibacterial osteogenesis abilities, greatly simplifying composition multifunctional material. Therefore, hydrogel containing MCDs...
Abstract: Natural and synthetic polymeric materials have been widely used in bone tissue engineering due to their similarity with extracellular matrices considerable biocompatibility biodegradability. A variety of techniques has applied modify the physicochemical, structural, biological properties meet specific requirements regeneration. This review aims provide a brief overview recent progress on synthesis fabrication for engineering. Commonly innovative processing fabricate different...
The behaviors and functions of individual cells, fundamental to the complexity multicellular organisms, are regulated by their integrated response a variety environmental cues such as soluble factors, extracellular matrix (ECM)-mediated signals, cell-cell interactions. Among these cues, biomechanical feature ECM, represented its elasticity, has been increasingly recognized dominating factor cell fate. This review article aims provide an overview general principles recent advances in field...
Abstract Repair of cartilage–bone interface tissue remains challenging, because it combines different cell types and gradients composition properties. To enable simultaneous regeneration bone, cartilage, especially their interface, a conically graded scaffold chitosan–gelatin hydrogel/poly( l ‐lactide‐co‐glycolide) (PLGA) was facilely prepared in the study. The hydrogel containing transforming growth factor β1 (TGF‐β1) used for chondrogenesis, while PLGA loading bone morphogenetic protein‐2...
Abstract Remote control of stem cell differentiation in vivo by stimuli‐responsive nanomaterials with the use tissue‐penetrative stimuli is an appealing strategy for versatile regulation therapy. In this study, upconversion nanotransducer (UCNT)‐based nanocomplex photolabile caging chondro‐inductive kartogenin (KGN) and/or either calcium chelator or supplier (caged calcium), and subsequent coupling integrin‐binding ligand via cyclodextrin‐adamantine supramolecular complexation utilized....
Poly(ether ether ketone) (PEEK) is a popular orthopaedic implant material due to the outstanding biocompatibility and mechanical properties. However, bacterial infections aseptic loosening during implantation can cause many clinical problems that may eventually lead failure. Therefore, endowing implants with antibacterial functions plays an important role in promoting integration between bone tissue ultimately, successful implantation. This study aimed develop biocompatible coating for PEEK...
Poly(ethylene glycol) (PEG)-based hydrogels are promising materials for biomedical applications because of their excellent hydrophilicity and biocompatibility. However, conventional chemically cross-linked PEG brittle under mechanical loading. The resilience rapid recovery abilities hydrogel implants critical in load-bearing tissues, such as articular cartilage, which routinely subjected to cyclic loadings high magnitude frequency. Here, we report the fabrication novel supramolecular by...