A5029564430- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Axon Guidance and Neuronal Signaling
- Supercapacitor Materials and Fabrication
- Graphene and Nanomaterials Applications
- Advanced battery technologies research
- Nanoplatforms for cancer theranostics
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Bone Tissue Engineering Materials
- Spinal Cord Injury Research
- Crystallography and molecular interactions
- Carbon and Quantum Dots Applications
- Advancements in Battery Materials
- Retinal Development and Disorders
- Conducting polymers and applications
- Nerve Injury and Rehabilitation
- Electrocatalysts for Energy Conversion
- Silk-based biomaterials and applications
- Advanced Nanomaterials in Catalysis
- Perovskite Materials and Applications
- Metal-Organic Frameworks: Synthesis and Applications
- Luminescence and Fluorescent Materials
- Optical properties and cooling technologies in crystalline materials
- Photoacoustic and Ultrasonic Imaging
Soochow University
2017-2025
First Affiliated Hospital of Soochow University
2017-2025
Huanghuai University
2019-2023
Anhui University
2019
Jinan University
2016
Huazhong University of Science and Technology
2015
Abstract Reactive oxygen species (ROS) plays a critical role in tissue repair, including bone. Therefore, detecting and regulating ROS is essential for monitoring facilitating bone repair. In this study, the first time, spatiotemporal profile of ROS, represented by hydrogen peroxide (H 2 O ), injury microenvironment using photoacoustic imaging technique visualized. The levels significantly increase upon injury, peak at certain stage healing, then gradually decrease toward baseline level. To...
Implant-associated infection is a major threat affecting the success of orthopedic surgeries. Although various materials scavenge bacteria by generating reactive oxygen species (ROS), intrinsic inability ROS to distinguish from cells notably limits therapeutic effects. Here, we found that arginine carbon dots (Arg-CDs) were transformed exhibited supreme antibacterial and osteoinductive activity. We further designed Schiff base bond between Arg-CDs aldehyde hyaluronic acid/gelatin...
The critical factor determining the in vivo effect of bone repair materials is microenvironment, which greatly depends on their abilities to promote vascularization and formation. However, implant are far from ideal candidates for guiding regeneration due deficient angiogenic osteogenic microenvironments. Herein, a double-network composite hydrogel combining vascular endothelial growth (VEGF)-mimetic peptide with hydroxyapatite (HA) precursor was developed build an microenvironment repair....
Abstract Repair of infectious bone defects remains a serious problem in clinical practice owing to the high risk infection and excessive reactive oxygen species (ROS) during early stage, residual bacteria delayed Osseo integrated interface later which jointly creates complex dynamic microenvironment leads non‐union. The melatonin carbon dots (MCDs) possess antibacterial osteogenesis abilities, greatly simplifying composition multifunctional material. Therefore, hydrogel containing MCDs...
Abstract Spinal cord injury (SCI) is a devastating that causes permanent loss of sensation and motor function. SCI repair significant challenge due to the limited regenerating ability adult neurons complex inflammatory microenvironment. After SCI, oxidative stress induced by excessive reactive oxygen species (ROS) often leads prolonged neuroinflammation results in sustained damage spinal tissue. Polydopamine (PDA) shows remarkable capability scavenging ROS treat numerous diseases. In this...
In addition to altered gene expression, pathological cytoskeletal dynamics in the axon are another key intrinsic barrier for regeneration central nervous system (CNS). Here, we show that knocking out myosin IIA and IIB (myosin IIA/B) retinal ganglion cells alone, either before or after optic nerve crush, induces significant regeneration. Combined Lin28a overexpression IIA/B knockout lead an additive promoting effect long-distance Immunostaining, RNA sequencing, western blot analyses reveal...
Abstract Stem cell implantation holds promise for enhancing bone repair, but risks of pathogen transmission and malignant transformation should not be ignored. Compared to stem implantation, recruitment endogenous cells injured sites is more critical in situ regeneration. In this study, based on the acidic microenvironment injury, an HG‐AA 1:1 ‐SDF‐1α composite hydrogel with a dual‐control intelligent switch function developed by incorporating stromal cell‐derived factor (SDF‐1α), arginine...
Axon regrowth is a key determinant of the restoration biological function nervous system after trauma. However, mature mammalian neurons have limited capacity for axon regeneration. We previously demonstrated that neuronal growth both in central and peripheral systems markedly enhanced when non-muscle myosin II (NMII) inhibited with blebbistatin. The activity NMII primarily regulated by MLCK MLCP via phosphorylation dephosphorylation its light chain, respectively; however, functional roles...
Inorganic lead halide perovskite CsPbX3 (X = Cl, Br, or I) nanocrystals are promising candidate materials for light-emitting devices and optoelectronics. Mn-Doped is of particular interest, as the Mn-doping introduces an additional emission band, making this material a white-light emitter. In study, Mn-doped CsPb(Br/Cl)3 prepared at room-temperature ambient pressure. The chemical environment Mn, luminescence these analyzed in detail using X-ray diffraction (XRD), extended absorption fine...
Although several genes have been identified to promote axon regeneration in the CNS, our understanding of molecular mechanisms by which mammalian is regulated still limited and fragmented. Here using female mouse sensory optic nerve as model systems, we reveal an unexpected role telomerase reverse transcriptase (TERT) regulation regeneration. We also provide evidence that TERT p53 act downstream c-Myc control More importantly, overexpression neurons retinal ganglion cells sufficient never...
Because of the limited regenerative ability central nervous system (CNS), effective treatments for spinal cord injury (SCI) are still lacking. After SCI, neuron loss and axon regeneration failure often result in irreversible functional impairment. The calcium overload induced by N-methyl-D-aspartate receptor (NMDAR) overactivation is critical cell death SCI. It has been reported that magnesium ion (Mg
A pivotal determinant for the success of tissue regeneration lies in establishment sufficient vasculature. Utilizing autologous grafts from donors offers dual advantage mitigating risk disease transmission and circumventing necessity post-transplant immunosuppression, rendering it an exemplary vascularization strategy. Among various potential donors, adipose emerges as a particularly auspicious source, being both widely available compositionally rich. Notably, adipose-derived microvascular...
Abstract While axon regeneration is a key determinant of functional recovery the nervous system after injury, it often poor in mature system. Influx extracellular calcium (Ca 2+ ) one first phenomena that occur following axonal and calcium/calmodulin‐dependent protein kinase II (CaMKII), target substrate for ions, regulates status cytoskeletal proteins such as F‐actin. Herein, we found peripheral axotomy activates CaMKII dorsal root ganglion (DRG) sensory neurons, inhibition impairs...
Axonal regeneration plays an important role in functional recovery after nervous system damage. However, axonal injury mammals, is often poor. The deletion of Krüppel-like factor-4 (Klf4) has been shown to promote retinal ganglion cells. the effects Klf4 on corticospinal tract and peripheral are unknown. In this study, using a mouse model sciatic nerve injury, we show that expression dorsal root sensory neurons was significantly reduced axotomy, suggesting associated with Klf4. vitro,...
Reconstruction of damaged nerves remains a significant unmet challenge in clinical medicine. Topographical and mechanical stimulations play important roles to repair peripheral nerve injury. The synergistic effects topography rigidity may significantly accelerate regeneration. In this work, nerve-guiding collagen/polylactic acid (PLA) electrospun scaffold is developed facilitate repair. obtained anisotropic PLA scaffolds simulate the directional arranged structure realistically promote...