A5101751022- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Osteoarthritis Treatment and Mechanisms
- Endoplasmic Reticulum Stress and Disease
- Protease and Inhibitor Mechanisms
- Bone and Joint Diseases
- Bone Metabolism and Diseases
- Bone Tissue Engineering Materials
- Inflammatory mediators and NSAID effects
- RNA Research and Splicing
- Toxin Mechanisms and Immunotoxins
- Graphene and Nanomaterials Applications
- TGF-β signaling in diseases
- Tissue Engineering and Regenerative Medicine
- Nerve injury and regeneration
First Affiliated Hospital of Shihezi University Medical College
2019-2025
Shihezi University
2023
Linyi People's Hospital
2020
Background Diabetes mellitus is a chronic metabolic disease with systemic complications. Patient diabetes have increased risks of bone fracture. Previous studies report that could affect metabolism, however, the underlying mechanism still unclear. Methods We isolated exosomes secreted by marrow mesenchymal stem cells normal and diabetic mice test their effects on osteogenesis adipogenesis. Then we screened differential microRNAs high-throughput sequencing explored function key microRNA in...
Abstract Stem cell implantation holds promise for enhancing bone repair, but risks of pathogen transmission and malignant transformation should not be ignored. Compared to stem implantation, recruitment endogenous cells injured sites is more critical in situ regeneration. In this study, based on the acidic microenvironment injury, an HG‐AA 1:1 ‐SDF‐1α composite hydrogel with a dual‐control intelligent switch function developed by incorporating stromal cell‐derived factor (SDF‐1α), arginine...
The occurrence of osteosarcoma (OS) is associated with abnormal expression many microRNAs (miRNAs). Exosomal miRNAs get much more attentions in intracellular communications. miR-1307 has been studied cancers, but its effects OS have not studied. We hypothesized that OS-derived exosomal regulates tumorigenesis. First, we found cell-derived exosomes (Exos) significantly promoted the proliferation, migration, and invasion cells. Secondly, was highly expressed (OS-Exos), human tissues, cell...
To investigate the potential role of circMTO1/miR-9-5p/NOX4 axis in liver cancer.Human genome-wide circrna microarray V2 was used for analyzing expression profile circRNAs human tissue samples. The TargetScan database to predict target genes. Gene overexpression and silencing hepatoma cell lines were achieved by transfecting cells with suitable constructs. Quantitative real time PCR Western blotting analyze gene protein levels. CCK-8 analysis performed detect proliferation transwell assay...
Abstract Objective TGFβ1 plays an important role in the metabolism of articular cartilage and bone; however, pathological mechanism targets degradation uncoupling subchondral bone remodeling remain unclear. Therefore, this study, we investigated relationship between major protein-degrading enzymes, evaluated high levels active thickening calcification cartilage. Materials Methods The expression enzymes clinical samples obtained from knee joint patients with osteoarthritis was detected by...
Sensory and motor nerve fibers of peripheral nerves have different anatomies regeneration functions after injury. To gain a clear understanding the biological processes behind these differences, we used labeling technique termed isobaric tags for relative absolute quantitation to investigate protein profiles spinal tissues from Sprague-Dawley rats. In response Wallerian degeneration, total 626 proteins were screened in sensory nerves, which 368 upregulated 258 downregulated. addition, 637...
Degradative enzymes such as matrix metalloproteinase (MMP) and disintegrin with platelet thrombin-sensitive protein-like motifs (ADAMTS) play a key role in the development of osteoarthritis (OA). We aimed to investigate effects OA subchondral osteoblasts on expression ADAMTS4, ADAMTS5, MMP-3, MMP-9, MMP-13 chondrocytes regulation mitogen-activated protein kinase (MAPK) signaling pathway.A rat knee model was constructed by cutting anterior cruciate ligament joints, normal articular cartilage...