A5046783530- Extracellular vesicles in disease
- TGF-β signaling in diseases
- Osteoarthritis Treatment and Mechanisms
- MicroRNA in disease regulation
- Bone Metabolism and Diseases
- Circular RNAs in diseases
- Inflammatory mediators and NSAID effects
First Affiliated Hospital of Shihezi University Medical College
2019-2021
Shihezi University
2019-2021
The occurrence of osteosarcoma (OS) is associated with abnormal expression many microRNAs (miRNAs). Exosomal miRNAs get much more attentions in intracellular communications. miR-1307 has been studied cancers, but its effects OS have not studied. We hypothesized that OS-derived exosomal regulates tumorigenesis. First, we found cell-derived exosomes (Exos) significantly promoted the proliferation, migration, and invasion cells. Secondly, was highly expressed (OS-Exos), human tissues, cell...
Abstract Objective TGFβ1 plays an important role in the metabolism of articular cartilage and bone; however, pathological mechanism targets degradation uncoupling subchondral bone remodeling remain unclear. Therefore, this study, we investigated relationship between major protein-degrading enzymes, evaluated high levels active thickening calcification cartilage. Materials Methods The expression enzymes clinical samples obtained from knee joint patients with osteoarthritis was detected by...
Abstract Background TGFβ1 plays an important role in the metabolism of articular cartilage and bone; however, pathological mechanism targets degradation uncoupling subchondral bone remodeling remain unclear. Therefore, this study, we investigated relationship between major protein-degrading enzymes, evaluated high levels active thickening calcification cartilage. Materials methods The expression enzymes clinical samples obtained from knee joint patients with osteoarthritis was detected by...