A5054851122- Electrospun Nanofibers in Biomedical Applications
- RNA Interference and Gene Delivery
- Neuroscience and Neuropharmacology Research
- Cardiac Ischemia and Reperfusion
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Nanomaterials in Catalysis
- 3D Printing in Biomedical Research
- Silk-based biomaterials and applications
- Adenosine and Purinergic Signaling
- Microfluidic and Bio-sensing Technologies
- Cellular Mechanics and Interactions
- Graphene and Nanomaterials Applications
- RNA modifications and cancer
- Thermal Regulation in Medicine
- Periodontal Regeneration and Treatments
- Cardiac Fibrosis and Remodeling
- RNA Research and Splicing
- Membrane Separation Technologies
- Tissue Engineering and Regenerative Medicine
- Osteoarthritis Treatment and Mechanisms
- Bat Biology and Ecology Studies
- Bone Tissue Engineering Materials
- Hemostasis and retained surgical items
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
Children's Hospital of Chongqing Medical University
2025
Chongqing Medical University
2025
Renji Hospital
2024-2025
Shanghai Jiao Tong University
2024-2025
Peking University
2024
The First People’s Hospital of Lianyungang
2020-2023
Xian Yang Central Hospital
2023
Lianyungang Oriental Hospital
2023
Zhejiang University
2023
Nanjing Medical University
2005-2022
Abstract Repair of cartilage–bone interface tissue remains challenging, because it combines different cell types and gradients composition properties. To enable simultaneous regeneration bone, cartilage, especially their interface, a conically graded scaffold chitosan–gelatin hydrogel/poly( l ‐lactide‐co‐glycolide) (PLGA) was facilely prepared in the study. The hydrogel containing transforming growth factor β1 (TGF‐β1) used for chondrogenesis, while PLGA loading bone morphogenetic protein‐2...
Abstract As activated microglia (MG) is an early sign that often precedes and triggers neuronal death, inhibition of microglial activation reduction subsequent neurotoxicity may offer therapeutic benefit. The present study demonstrates rat primary cultured MG expressed Kir6.1 SUR2 subunits K ATP channel, which was identical to in BV‐2 cell line. classic channel opener pinacidil selective mitochondrial (mito‐K ) diazoxide prevented rotenone‐induc production pro‐inflammatory factors (tumour...
Abstract Studies on the development of central nervous system (CNS) primarily rely use specific molecular markers for different types neural cells. S100B is widely being used as a marker astrocytes in CNS. However, specificity its expression astrocyte lineage has not been systematically investigated and thus remained lingering issue. In this study, we provide several lines genetic evidences that expressed both protoplasmic myelinating oligodendrocytes. developing spinal cord, first ventral...
The nutritional treatment of methicillin-resistant Staphylococcus aureus sepsis combined with pulmonary embolism presents considerable challenges due to the risks associated tube placement, coagulation disorders, severe infections, digestive limitations, and fluid restrictions in pediatric patients. This report discusses case an approximately 13-year-old female patient admitted symptoms right lower limb pain, fever, cough accompanied by shortness breath. was assessed be at moderate risk...
An NIR-controlled gene expression system based on upconverting rods (UCRs) is demonstrated. The UCRs can harvest the “biocompatible” NIR light and convert it into local UV light, resulting in cleavage of photosensitive molecule (4-(hydroxymethyl)-3-nitrobenzoic acid, ONA) on-demand release carriers, thus realizing target at high spatial temporal resolutions. As a service to our authors readers, this journal provides supporting information supplied by authors. Such materials are peer reviewed...
Cationic complexes self-assembled from REDV peptide-modified PEG-trimethyl chitosan (TMC-<italic>g</italic>-PEG-REDV) polyplexes show efficient targeted delivery of miRNA-126 to vascular endothelial cells (VECs).
Bacterial infections are a growing global public health problem, exacerbated by the widespread and often inappropriate use of antibiotics, leading to emergence non-antibiotic pathogens. Herein, we synthesized chitosan-Prussian blue nanozyme (CS@PB), agent, for universal antibacterial anti-inflammatory treatment bacterial infections. Confocal microscopy images showed that CS@PB significantly enhanced physical interaction between chitosan bacteria, thereby increasing ability. Moreover, these...
Abstract Clinical utility of small‐diameter vascular grafts is still challenging in blood vessel regeneration owing to thrombosis and intimal hyperplasia. To cope with the issues, modulation gene expression via microRNAs (miRNAs) could be a feasible approach by rational regulating physiological activities both endothelial cells (VECs) smooth muscle (VSMCs). Our previous studies demonstrated that individually loaded miRNA‐126 (miR‐126) or miRNA‐145 (miR‐145) electrospun membranes showed...
Abstract Inhibition of astrocytic apoptosis has been regarded as a novel prospective strategy for treating neurodegenerative disorders such Parkinson’s disease. In the present study, we demonstrated that iptakalim (IPT), an ATP‐sensitive potassium channel (K ATP channel) opener, exerted protective effect on MPP + ‐induced apoptosis, which was reversed by selective mitochondrial K blocker 5‐hydroxydecanoate. Further study revealed IPT inhibited glutathione (GSH) depletion, membrane potential...
Amphiphilic polymers with pH-responsive abilities have been widely used as carriers for intracellular delivery of bioactive substances, while their membrane-disruptive activity exerted on cells is a critical characteristic that determines efficiency. Herein, we present novel method to prepare amphiphilic and by chemically tethering l-phenylalanine methyl ester followed Nε-carbobenzyloxy-l-lysine benzyl the side carboxylic acid groups poly(aspartic acid). The obtained phenylalanine-...
Magnetic Fe3O4 nanoparticles were prepared with coprecipitatation method and covered SiO2 to form the core-shell Fe3O4@SiO2 nanoparticles. Then modified glutaradehyde for functionalization of surface aldehyde groups. The transmission electron microscopy confirmed structure revealed that size was around 10 nm. It observed lipase immobilized on successfully from Fourier transform infrared spectra. characterized compared free enzyme. There are no significant differences in optimal pH,...