A5035878637- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Catalytic Processes in Materials Science
- Luminescence and Fluorescent Materials
- Catalysis and Oxidation Reactions
- Advanced biosensing and bioanalysis techniques
- Photoreceptor and optogenetics research
- Virus-based gene therapy research
- Cancer Research and Treatments
- 3D Printing in Biomedical Research
- Advancements in Transdermal Drug Delivery
- Gut microbiota and health
- Probiotics and Fermented Foods
- Nanoparticle-Based Drug Delivery
- Immune cells in cancer
- Electrocatalysts for Energy Conversion
- Nanomaterials for catalytic reactions
- Luminescence Properties of Advanced Materials
- Photodynamic Therapy Research Studies
- Oxidative Organic Chemistry Reactions
- Fuel Cells and Related Materials
- Nanocluster Synthesis and Applications
- RNA Interference and Gene Delivery
- Neuroinflammation and Neurodegeneration Mechanisms
- Synthesis of heterocyclic compounds
Tianjin University
2016-2025
Tianjin Medical University
2019-2025
Wenzhou University
2024
Tianjin Economic-Technological Development Area
2023
Nanjing Forestry University
2022
Jilin University
2015-2021
Nankai University
2019
Collaborative Innovation Center of Chemical Science and Engineering Tianjin
2015-2016
Xinxiang Medical University
2013-2016
Jilin Medical University
2015
Studies were performed in a long-term effort to develop clinically translatable, tissue engineered adipose constructs for reconstructive, correctional, and cosmetic indications. Rat preadipocytes harvested, isolated, expanded ex vivo, seeded within PLGA scaffolds. Preadipocyte-seeded acellular (control) scaffolds implanted 1-12 months. Explanted stained with osmium tetroxide, processed, counterstained using H&E. Quantitative histomorphometric analysis was on all sections determine the amount...
In vivo the application of optogenetic manipulation in deep tissue is seriously obstructed by limited penetration depth visible light that continually applied to activate a photoactuator. Herein, we designed versatile upconversion nanosystem based on blue-light-mediated heterodimerization module and rare-earth nanoparticles (UCNs). The UCNs worked as nanotransducer convert external deep-tissue-penetrating near-infrared (NIR) local blue noninvasively photoreceptors for vivo. this,...
Catalysts have achieved efficacy in scavenging reactive oxygen species (ROS) to eliminate neuroinflammation, but it ignores the essential fact of blocking source ROS regeneration. Here, we report single-atom catalysts (SACs) Pt/CeO2, which can effectively catalyze breakdown existing and induce mitochondrial membrane potential (Δψm) depolarization by interfering with α-glycerophosphate shuttle pathway malate-aspartate pathway, indirectly triggering self-clearance dysfunctional mitochondria...
Abstract Uncontrollable massive bleeding caused by trauma will cause the patient to lose a large amount of blood and drop body temperature quickly, resulting in hemorrhagic shock. This study aims develop hemostatic product for hemorrhage management. In this study, waste pomelo peel as raw material is chosen. It underwent processes carbonization, purification, freeze‐drying. The obtained carbonized (CPP) hydrophilic exhibits porous structure (nearly 80% porosity). water/blood absorption ratio...
MgFe2O4 with inverse spinel structure is demonstrated to be an efficient support for constructing practical potential Pt catalyst (Pt/MgFe2O4). The resultant Pt/MgFe2O4 exhibits excellent catalytic behavior in CO oxidation under normal temperature and humidity. TOF calculated based on the content of 0.131 s–1. performance attributes presence surface undercoordinated lattice oxygens support. These could participate initial then recovered O2 conditions. Over this catalyst, should mainly follow...
Excess reactive oxygen species (ROS) produced by abnormal mitochondria is one of the critical triggers rheumatoid arthritis (RA). Existing nanocatalytic therapies can only catalyze breakdown ROS but cannot address root cause production, i.e., mitochondria. Here, we designed an ultrasound (US) piezoelectric catalytic therapy, which induce mitophagy in a spatiotemporally controlled manner to treat RA. The prepared two-dimensional nanosheets (NSs) Fe/BiOCl with US activity efficiently generate...
As a transdermal drug delivery method, microneedles offer minimal invasiveness, painlessness, and precise in-situ treatment. However, current rely on passive diffusion, leading to uncontrollable penetration. To overcome this, we developed pneumatic microneedle patch that uses live Enterobacter aerogenes as microengines actively control delivery. These microbes generate gas, driving drugs into deeper tissues, with adjustable glucose concentration allowing over the process. Our results showed...
Combined cancer therapy possesses many advantages including improved tumoricidal efficacy, reduced side effects, and retarded drug resistance. Herein, a protein–polymer bioconjugate-coated multifunctional upconversion nanosystem, consisting of nanoparticles (UCNs) core, tailored amphiphilic bioconjugate shell, photosensitizer zinc phthalocyanine (ZnPc) antitumor doxorubicin coloaded inside, was elaborately developed for combined photodynamic (PDT) chemotherapy. In this system, UCNs core...
Abstract A composite of Fe 3 O 4 nanoparticles anchored on a carbon support (Fe /C), possessing both superparamagnetism and molecular oxygen activating properties, was prepared by an ammonia‐assisted precipitation method. /C could catalyze the selective oxidation various benzyl alcohols with air as oxidant source, be easily separated recycled external magnet. The small particle size interaction between endow catalyst relatively high reducibility. Its state is easy to change. This intrinsic...
Optical imaging-guidance of indocyanine green (ICG) for photothermal therapy (PTT) has great latent capacity in cancer therapy. However, the conventional optical image-guidance mode caused strong tissue autofluorescence living tissue, which leads to accurate infrared light irradiation cannot be conducted. In this article, ICG and persistent luminescence phosphors (PLPs) coloaded mesoporous silica nanocarriers ((ICG+PLPs)@mSiO2) were first designed prepared luminescent imaging-guided PTT. The...
The secretome of mesenchymal stem cell (MSC) offers a series immunoregulatory properties and is regarded as an effective method mitigating secondary neuroinflammation induced by traumatic brain injury (TBI). adipose-derived MSCs (ASC-ST) was collected under hypoxia conditions. Proteomics data were analyzed liquid chromatography–tandem mass spectrometry (LC-MS/MS), concentrations major components tested. After the TBI caused electric cortical contusion impactor, rats injected ASC-ST through...
BackgroundPsoriasis is a chronic inflammatory and systemic disease with significant therapeutic challenges. Previous studies have indicated that Datura metel L. (DML) possesses anti-inflammatory properties other beneficial effects for psoriasis treatment, yet its regulatory mechanisms underlying these remain inadequately explored.ObjectiveThis study aimed to evaluate the efficacy of DML in psoriatic mouse model investigate through joint analyses.MethodsAn imiquimod (IMQ)- induced was...
Abstract Recent advances in cancer treatments such as targeted therapy and immunotherapy, have brought hope for curing a variety of cancers. However, there are ongoing challenges poor targeting, biocompatibility biosafety. Engineered bacteria can cope with these problems, providing unique therapeutic approach the treatment tumors. Nanotechnology offers potential to modify surface bacteria, use biofilm coating technology physically encapsulate help escape host immune system improve efficiency...
An NIR-controlled gene expression system based on upconverting rods (UCRs) is demonstrated. The UCRs can harvest the “biocompatible” NIR light and convert it into local UV light, resulting in cleavage of photosensitive molecule (4-(hydroxymethyl)-3-nitrobenzoic acid, ONA) on-demand release carriers, thus realizing target at high spatial temporal resolutions. As a service to our authors readers, this journal provides supporting information supplied by authors. Such materials are peer reviewed...
Optical imaging for biological applications is in need of more sensitive tool. Persistent luminescent nanophosphors enable highly vivo optical detection and almost completely avoid tissue autofluorescence. Nevertheless, the actual persistent necessitate ex activation before systemic operation, which severely restricted use long-term vivo. Hence, we introduced a novel generation nanophosphors, based on (Zn2SiO4:Mn):Y3+, Yb3+, Tm3+ upconverting nanophosphors; these can be excited through...
The FeO<sub>x</sub>support not only affects the oxidation state of Pt nanoparticles, but also provides active sites in catalytic process.